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    H2bc26 H2B clustered histone 26 [ Mus musculus (house mouse) ]

    Gene ID: 382522, updated on 17-Aug-2024

    Summary

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    Official Symbol
    H2bc26provided by MGI
    Official Full Name
    H2B clustered histone 26provided by MGI
    Primary source
    MGI:MGI:1922442
    See related
    Ensembl:ENSMUSG00000080712 AllianceGenome:MGI:1922442
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H2bu1; H2bu1-ps; H2bc26-ps; Hist3h2bb; 4933432H21; B2Hist3h2bb; Hist3h2bb-ps; 4930534G10Rik
    Summary
    Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a replication-dependent histone that is a member of the histone H2b family. [provided by RefSeq, Feb 2021]
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    Genomic context

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    See H2bc26 in Genome Data Viewer
    Location:
    11 B1.3; 11 36.38 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58842961..58845278, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58954048..58954512, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 187 Neighboring gene predicted gene, 51864 Neighboring gene STARR-positive B cell enhancer ABC_E3954 Neighboring gene H2B clustered histone 27 Neighboring gene STARR-positive B cell enhancer ABC_E114 Neighboring gene H2A clustered histone 25 Neighboring gene tripartite motif-containing 17 Neighboring gene STARR-positive B cell enhancer ABC_E5230 Neighboring gene STARR-positive B cell enhancer ABC_E6989 Neighboring gene H3.4 histone, cluster member

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone modifications associated with somatic hypermutation. Odegard VH, et al. Immunity, 2005 Jul. PMID 16039583
    2. Phosphorylation of histone H2B at DNA double-strand breaks. Fernandez-Capetillo O, et al. J Exp Med, 2004 Jun 21. PMID 15197225, Free PMC Article
    3. Gene mapping of sperm quality parameters in recombinant inbred strains of mice. Golas A, et al. Int J Dev Biol, 2008. PMID 18311719
    4. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542, Free PMC Article
    5. Insights into specificity, redundancy and new cellular functions of C/EBPa and C/EBPb transcription factors through interactome network analysis. Cirilli M, et al. Biochim Biophys Acta Gen Subj, 2017 Feb. PMID 27746211

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Clone Names

    • MGC130256

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone H2B type 3-B
    Names
    H2B.U histone 1, pseudogene
    histone 3, H2bb
    histone cluster 3, H2bb, pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393523.1 → NP_001380452.1  histone H2B type 3-B

      Status: VALIDATED

      Source sequence(s)
      AL662809
      UniProtKB/Swiss-Prot
      Q3B7Z7, Q8CGP0
      UniProtKB/TrEMBL
      A0JLV3
      Related
      ENSMUSP00001091675.1, ENSMUST00000117558.3
      Conserved Domains (1) summary
      smart00427
      Location:36 → 124
      H2B; Histone H2B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58842961..58845278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_134309.1: Suppressed sequence

      Description
      NR_134309.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGP0.3 GenPept UniProtKB/Swiss-Prot:Q8CGP0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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