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    Magea14 MAGE family member A14 [ Mus musculus (house mouse) ]

    Gene ID: 74279, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Magea14provided by MGI
    Official Full Name
    MAGE family member A14provided by MGI
    Primary source
    MGI:MGI:1921529
    See related
    Ensembl:ENSMUSG00000031118 AllianceGenome:MGI:1921529
    Gene type
    protein coding
    RefSeq status
    PREDICTED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700080O16Rik
    Summary
    Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Restricted expression toward testis adult (RPKM 17.8) See more
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    Genomic context

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    See Magea14 in Genome Data Viewer
    Location:
    X A5; X 28.33 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (51057570..51062379, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (51968693..51973502, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 35727 Neighboring gene STARR-seq mESC enhancer starr_47165 Neighboring gene ubiquitin specific peptidase 26 Neighboring gene STARR-seq mESC enhancer starr_47166 Neighboring gene predicted gene, 22539 Neighboring gene STARR-seq mESC enhancer starr_47167 Neighboring gene predicted gene, 35790 Neighboring gene STARR-seq mESC enhancer starr_47168 Neighboring gene STARR-seq mESC enhancer starr_47170 Neighboring gene glypican 4 Neighboring gene STARR-seq mESC enhancer starr_47171 Neighboring gene STARR-seq mESC enhancer starr_47173 Neighboring gene STARR-seq mESC enhancer starr_47175 Neighboring gene STARR-seq mESC enhancer starr_47176 Neighboring gene STARR-seq mESC enhancer starr_47177 Neighboring gene glypican 3 Neighboring gene microRNA 6384

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulatory variation at glypican-3 underlies a major growth QTL in mice. Oliver F, et al. PLoS Biol, 2005 May. PMID 15799711, Free PMC Article
    2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130196, MGC130197

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC74279

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028851.1 → NP_083127.1  uncharacterized protein LOC74279

      See identical proteins and their annotated locations for NP_083127.1

      Status: PREDICTED

      Source sequence(s)
      AK006959
      Consensus CDS
      CCDS53068.1
      UniProtKB/TrEMBL
      Q9D9G4
      Related
      ENSMUSP00000033449.2, ENSMUST00000033449.8
      Conserved Domains (2) summary
      pfam01454
      Location:100 → 252
      MAGE; MAGE family
      pfam12440
      Location:16 → 66
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      51057570..51062379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541552.4 → XP_006541615.1  uncharacterized protein LOC74279 isoform X1

      See identical proteins and their annotated locations for XP_006541615.1

      UniProtKB/TrEMBL
      Q9D9G4
      Related
      ENSMUSP00000110516.2, ENSMUST00000114866.2
      Conserved Domains (2) summary
      pfam01454
      Location:100 → 252
      MAGE; MAGE family
      pfam12440
      Location:16 → 66
      MAGE_N; Melanoma associated antigen family N terminal

    2. XM_030251513.1 → XP_030107373.1  uncharacterized protein LOC74279 isoform X1

      UniProtKB/TrEMBL
      Q9D9G4
      Conserved Domains (2) summary
      pfam01454
      Location:100 → 252
      MAGE; MAGE family
      pfam12440
      Location:16 → 66
      MAGE_N; Melanoma associated antigen family N terminal

    3. XM_006541551.4 → XP_006541614.1  uncharacterized protein LOC74279 isoform X1

      See identical proteins and their annotated locations for XP_006541614.1

      UniProtKB/TrEMBL
      Q9D9G4
      Conserved Domains (2) summary
      pfam01454
      Location:100 → 252
      MAGE; MAGE family
      pfam12440
      Location:16 → 66
      MAGE_N; Melanoma associated antigen family N terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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