Olig3 oligodendrocyte transcription factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Olig3provided by MGI
Official Full Name: oligodendrocyte transcription factor 3provided by MGI
Primary source: MGI:MGI:2149955
See related: Ensembl:ENSMUSG00000045591 AllianceGenome:MGI:2149955
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bhlhb7; oligo3; bHLHe20
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II; spinal cord motor neuron cell fate specification; and spinal cord motor neuron migration. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; future hindbrain; genitourinary system; inner ear; and skeletal muscle. Orthologous to human OLIG3 (oligodendrocyte transcription factor 3). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: human all
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Genomic context

Location:: 10 A3; 10 8.33 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (19232287..19234352)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (19356539..19358604)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Olig3 plays different roles in regulating the development of dorsal and ventral spinal cord
Title: Olig3 is not involved in the ventral patterning of spinal cord.
The fate of class A neurons was not correctly determined in Olig3 mutants. As a consequence, the nucleus of the solitary tract did not form, and precerebellar nuclei, such as the inferior olivary nucleus, were absent or small.
Title: The bHLH transcription factor Olig3 marks the dorsal neuroepithelium of the hindbrain and is essential for the development of brainstem nuclei.
Olig3 is specifically expressed in dorsal progenitor 1 domains of neural progenitor cells in the caudal hindbrain and regulates the fates of these neural progenitor cells.
Title: Control of precerebellar neuron development by Olig3 bHLH transcription factor.
dorsal Olig3 cells contribute to dorsal midline cells and commissural interneurons at intermediate and ventral levels
Title: Short-term lineage analysis of dorsally derived Olig3 cells in the developing spinal cord.
Olig3 is specifically and transiently expressed in different types of progenitors of embryonic central nervous system and then disappears in the course of development
Title: Non-overlapping expression of Olig3 and Olig2 in the embryonic neural tube.
Olig3 expression distinguishes the two major classes of progenitors in the dorsal spinal cord and determines the distinct specification program of class A neurons.
Title: The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord.
Wnt/beta-catenin signals act upstream of Olig3 in the specification of dI2 and dI3 neurons.
Title: Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spinal cord motor neuron cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: oligodendrocyte transcription factor 3

Names: basic helix-loop-helix domain-containing class B protein 7; oligodendrocyte-specific bHLH transcription factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.