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    Ccdc154 coiled-coil domain containing 154 [ Mus musculus (house mouse) ]

    Gene ID: 207209, updated on 9-Aug-2024

    Summary

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    Official Symbol
    Ccdc154provided by MGI
    Official Full Name
    coiled-coil domain containing 154provided by MGI
    Primary source
    MGI:MGI:2685163
    See related
    Ensembl:ENSMUSG00000059562 AllianceGenome:MGI:2685163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ntl; Gm317; Ccdc157
    Summary
    Acts upstream of or within bone mineralization involved in bone maturation; bone resorption; and odontogenesis. Predicted to be located in endosome. Used to study autosomal recessive osteopetrosis 1. Orthologous to human CCDC154 (coiled-coil domain containing 154). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 10.0), stomach adult (RPKM 1.3) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc154 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25381142..25390887)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25162175..25171913)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene pentraxin 4 Neighboring gene chloride channel, voltage-sensitive 7 Neighboring gene microRNA 12188 Neighboring gene intestine-critical region regulatory element Neighboring gene proline and glutamate rich with coiled coil 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25321285-25321526 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4 Neighboring gene predicted gene, 52286 Neighboring gene unkempt family like zinc finger

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CCDC154 Mutant Caused Abnormal Remodeling of the Otic Capsule and Hearing Loss in Mice. Xu K, et al. Front Cell Dev Biol, 2021. PMID 33614666, Free PMC Article
    2. Overexpression of a novel osteopetrosis-related gene CCDC154 suppresses cell proliferation by inducing G2/M arrest. Liao W, et al. Cell Cycle, 2012 Sep 1. PMID 22895184, Free PMC Article
    3. A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots. Lu X, et al. Eur J Oral Sci, 2009 Dec. PMID 20121924, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Spontaneous (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in bone mineralization involved in bone maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within bone mineralization involved in bone maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tooth eruption IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 154
    Names
    Grailexp predicted
    golgin-160-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079929.2 → NP_001073398.2  coiled-coil domain-containing protein 154

      See identical proteins and their annotated locations for NP_001073398.2

      Status: VALIDATED

      Source sequence(s)
      AK133084, JN935900
      Consensus CDS
      CCDS50032.2
      UniProtKB/Swiss-Prot
      G9JV17, Q3V0K0, Q6RUT8
      UniProtKB/TrEMBL
      S4R1F0
      Related
      ENSMUSP00000138090.2, ENSMUST00000182621.8
      Conserved Domains (1) summary
      pfam15450
      Location:48 → 573
      CCDC154; Coiled-coil domain-containing protein 154

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25381142..25390887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006523949.4 → XP_006524012.1  coiled-coil domain-containing protein 154 isoform X1

      UniProtKB/TrEMBL
      S4R1F0
      Conserved Domains (1) summary
      pfam15450
      Location:48 → 574
      CCDC154; Coiled-coil domain-containing protein 154

    2. XM_006523951.4 → XP_006524014.1  coiled-coil domain-containing protein 154 isoform X2

      UniProtKB/TrEMBL
      S4R1F0
      Conserved Domains (1) summary
      pfam15450
      Location:48 → 485
      CCDC154; Coiled-coil domain-containing protein 154

    3. XM_006523952.4 → XP_006524015.1  coiled-coil domain-containing protein 154 isoform X3

      Conserved Domains (1) summary
      pfam15450
      Location:48 → 430
      CCDC154; Coiled-coil domain-containing protein 154

    4. XM_006523954.4 → XP_006524017.1  coiled-coil domain-containing protein 154 isoform X5

      Conserved Domains (1) summary
      pfam15450
      Location:48 → 429
      CCDC154; Coiled-coil domain-containing protein 154

    5. XM_006523955.4 → XP_006524018.1  coiled-coil domain-containing protein 154 isoform X6

      Conserved Domains (1) summary
      pfam15450
      Location:48 → 431
      CCDC154; Coiled-coil domain-containing protein 154

    6. XM_006523953.1 → XP_006524016.1  coiled-coil domain-containing protein 154 isoform X4

      Conserved Domains (1) summary
      pfam15450
      Location:1 → 352
      CCDC154; Coiled-coil domain-containing protein 154

    RNA

    1. XR_385305.4 RNA Sequence

    2. XR_385306.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6RUT8.3 GenPept UniProtKB/Swiss-Prot:Q6RUT8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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