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    Golga4 golgin A4 [ Mus musculus (house mouse) ]

    Gene ID: 54214, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Golga4provided by MGI
    Official Full Name
    golgin A4provided by MGI
    Primary source
    MGI:MGI:1859646
    See related
    Ensembl:ENSMUSG00000038708 AllianceGenome:MGI:1859646
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Olp-1
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in Golgi to plasma membrane protein transport and positive regulation of axon extension. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human GOLGA4 (golgin A4). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.1), placenta adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Golga4 in Genome Data Viewer
    Location:
    9 F3; 9 70.23 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118335280..118411587)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (118506196..118582519)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33408 Neighboring gene STARR-seq mESC enhancer starr_25456 Neighboring gene predicted gene, 33460 Neighboring gene eomesodermin Neighboring gene STARR-seq mESC enhancer starr_25460 Neighboring gene family with sequence similarity 64, member A pseudogene Neighboring gene integrin alpha 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118586586-118586773 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118623570-118623818 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:118625206-118625362 Neighboring gene predicted gene 10157 Neighboring gene predicted gene, 39454

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis and male fertility in mice. Guo S, et al. Biochem Biophys Res Commun, 2020 Aug 27. PMID 32736686
    2. OlP-1, a novel protein that distinguishes early oligodendrocyte precursors. Gay D, et al. J Neurosci Res, 1997 Nov 15. PMID 9404721
    3. Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development. Cowan DA, et al. DNA Cell Biol, 2002 Jul. PMID 12162805
    4. A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo. Lieu ZZ, et al. Proc Natl Acad Sci U S A, 2008 Mar 4. PMID 18308930, Free PMC Article
    5. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis and male fertility in mice.
      Title: GOLGA4, A Golgi matrix protein, is dispensable for spermatogenesis and male fertility in mice.
    2. golgin-245 is a key regulator of TNF secretion; LPS activation of macrophages results in increased Golgi carriers for export, up-regulating the transport pathway for TNF export.
      Title: A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo.
    3. Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development.
      Title: Characterization of mouse tGolgin-1 (golgin-245/trans-golgi p230/256 kD golgin) and its upregulation during oligodendrocyte development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to plasma membrane protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in Golgi vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of axon extension IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily A member 4
    Names
    golgi autoantigen, golgin subfamily a, 4
    golgin-245
    tGolgin-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410161.1 → NP_001397090.1  golgin subfamily A member 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC173340, CT486004

    2. NM_001410162.1 → NP_001397091.1  golgin subfamily A member 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC173340, CT486004

    3. NM_018748.4 → NP_061218.2  golgin subfamily A member 4 isoform 1

      See identical proteins and their annotated locations for NP_061218.2

      Status: VALIDATED

      Source sequence(s)
      AC173340, CT486004
      Consensus CDS
      CCDS40801.1
      UniProtKB/Swiss-Prot
      O70365, Q8CGH6, Q91VW5
      Related
      ENSMUSP00000081880.5, ENSMUST00000084820.6
      Conserved Domains (5) summary
      pfam05483
      Location:492 → 1191
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00755
      Location:2182 → 2225
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:1461 → 2148
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:880 → 1707
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl19219
      Location:880 → 956
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      118335280..118411587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155104.1 → XP_036010997.1  golgin subfamily A member 4 isoform X2

      Conserved Domains (3) summary
      smart00755
      Location:2221 → 2264
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:732 → 1531
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:197 → 1045
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_036155103.1 → XP_036010996.1  golgin subfamily A member 4 isoform X1

      Conserved Domains (3) summary
      smart00755
      Location:2222 → 2265
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:733 → 1532
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:197 → 1046
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_036155105.1 → XP_036010998.1  golgin subfamily A member 4 isoform X3

      Conserved Domains (3) summary
      smart00755
      Location:2222 → 2265
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:733 → 1532
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:197 → 1046
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. XM_036155106.1 → XP_036010999.1  golgin subfamily A member 4 isoform X4

      Conserved Domains (3) summary
      smart00755
      Location:2221 → 2264
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:732 → 1531
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:197 → 1045
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_017313473.3 → XP_017168962.1  golgin subfamily A member 4 isoform X6

      Conserved Domains (4) summary
      smart00755
      Location:2214 → 2257
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:725 → 1524
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:363 → 1074
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:189 → 453
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    6. XM_036155107.1 → XP_036011000.1  golgin subfamily A member 4 isoform X8

      Conserved Domains (3) summary
      smart00755
      Location:2214 → 2257
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:725 → 1524
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:197 → 1038
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. XM_036155108.1 → XP_036011001.1  golgin subfamily A member 4 isoform X9

      Conserved Domains (3) summary
      smart00755
      Location:2194 → 2237
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:705 → 1504
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:197 → 1018
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. XM_017313474.3 → XP_017168963.1  golgin subfamily A member 4 isoform X11

      Conserved Domains (3) summary
      smart00755
      Location:2187 → 2230
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:698 → 1497
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:339 → 1047
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_017313475.3 → XP_017168964.1  golgin subfamily A member 4 isoform X12

      Conserved Domains (3) summary
      smart00755
      Location:2186 → 2229
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:697 → 1496
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:339 → 1046
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    10. XM_036155111.1 → XP_036011004.1  golgin subfamily A member 4 isoform X14

      Conserved Domains (2) summary
      smart00755
      Location:2186 → 2229
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:697 → 1496
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    11. XM_036155109.1 → XP_036011002.1  golgin subfamily A member 4 isoform X10

      Conserved Domains (3) summary
      smart00755
      Location:2189 → 2232
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:700 → 1499
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:164 → 1017
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. XM_017313477.3 → XP_017168966.1  golgin subfamily A member 4 isoform X16

      Conserved Domains (4) summary
      smart00755
      Location:2181 → 2224
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:692 → 1491
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:330 → 1041
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:156 → 420
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    13. XM_036155113.1 → XP_036011006.1  golgin subfamily A member 4 isoform X18

      Conserved Domains (3) summary
      smart00755
      Location:2161 → 2204
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:672 → 1471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:164 → 989
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    14. XM_017313479.3 → XP_017168968.1  golgin subfamily A member 4 isoform X21

      Conserved Domains (3) summary
      smart00755
      Location:2153 → 2196
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:664 → 1463
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:306 → 1013
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    15. XM_036155115.1 → XP_036011008.1  golgin subfamily A member 4 isoform X22

      Conserved Domains (3) summary
      smart00755
      Location:1971 → 2014
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:482 → 1281
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:83 → 778
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    16. XM_036155117.1 → XP_036011010.1  golgin subfamily A member 4 isoform X26

      Conserved Domains (2) summary
      smart00755
      Location:1936 → 1979
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:447 → 1246
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    17. XM_017313478.2 → XP_017168967.1  golgin subfamily A member 4 isoform X19

      Conserved Domains (3) summary
      smart00755
      Location:2154 → 2197
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:665 → 1464
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:306 → 1014
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    18. XM_017313476.1 → XP_017168965.1  golgin subfamily A member 4 isoform X15

      Conserved Domains (4) summary
      smart00755
      Location:2182 → 2225
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:693 → 1492
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:301 → 1042
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:156 → 420
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    19. XM_006512187.5 → XP_006512250.1  golgin subfamily A member 4 isoform X5

      See identical proteins and their annotated locations for XP_006512250.1

      Conserved Domains (4) summary
      smart00755
      Location:2215 → 2258
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:726 → 1525
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:334 → 1075
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      TIGR02169
      Location:189 → 453
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    20. XM_036155110.1 → XP_036011003.1  golgin subfamily A member 4 isoform X13

      Conserved Domains (2) summary
      smart00755
      Location:2187 → 2230
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:698 → 1497
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    21. XM_036155112.1 → XP_036011005.1  golgin subfamily A member 4 isoform X17

      Conserved Domains (3) summary
      smart00755
      Location:2164 → 2207
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:675 → 1474
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:139 → 988
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    22. XM_036155116.1 → XP_036011009.1  golgin subfamily A member 4 isoform X22

      Conserved Domains (3) summary
      smart00755
      Location:1971 → 2014
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:482 → 1281
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:83 → 778
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    23. XM_017313482.3 → XP_017168971.1  golgin subfamily A member 4 isoform X24

      Conserved Domains (3) summary
      smart00755
      Location:1963 → 2006
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:474 → 1273
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:112 → 823
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    24. XM_017313480.3 → XP_017168969.1  golgin subfamily A member 4 isoform X23

      Conserved Domains (3) summary
      smart00755
      Location:1964 → 2007
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:475 → 1274
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:83 → 824
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    25. XM_017313483.1 → XP_017168972.1  golgin subfamily A member 4 isoform X25

      Conserved Domains (3) summary
      smart00755
      Location:1963 → 2006
      Grip; golgin-97, RanBP2alpha,Imh1p and p230/golgin-245
      COG1196
      Location:474 → 1273
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:112 → 823
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_004935483.1 RNA Sequence

    2. XR_004935484.1 RNA Sequence

    3. XR_004935487.1 RNA Sequence

    4. XR_004935486.1 RNA Sequence

    5. XR_004935488.1 RNA Sequence

    6. XR_004935485.1 RNA Sequence

    7. XR_004935489.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VW5.2 GenPept UniProtKB/Swiss-Prot:Q91VW5

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