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    DYNLT3 dynein light chain Tctex-type 3 [ Homo sapiens (human) ]

    Gene ID: 6990, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DYNLT3provided by HGNC
    Official Full Name
    dynein light chain Tctex-type 3provided by HGNC
    Primary source
    HGNC:HGNC:11694
    See related
    Ensembl:ENSG00000165169 MIM:300302; AllianceGenome:HGNC:11694
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RP3; TCTE1L; TCTEX1L
    Summary
    This gene encodes a member of a subclass of dynein light chains. The encoded protein homodimerizes and forms the light chain component of the cytoplasmic dynein motor protein complex. This protein may be important for binding dynein to specific cargos including the spindle checkpoint protein BUB3. This protein may also function independently of dynein as a transcriptional modulator. Pseudogenes of this gene are found on chromosomes 2 and 20.[provided by RefSeq, Mar 2010]
    Expression
    Ubiquitous expression in adrenal (RPKM 36.5), esophagus (RPKM 35.0) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DYNLT3 in Genome Data Viewer
    Location:
    Xp11.4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (37838836..37847571, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (37242419..37251154, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (37698089..37706824, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene H2A.L variant histone 1M, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29518 Neighboring gene X-linked Kx blood group antigen, Kell and VPS13A binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29520 Neighboring gene cytochrome b-245 beta chain Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20733 Neighboring gene RNA, U6 small nuclear 49, pseudogene Neighboring gene synaptotagmin like 5 Neighboring gene sterol-C4-methyl oxidase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The role of DYNLT3 in breast cancer proliferation, migration, and invasion via epithelial-to-mesenchymal transition. Wang H, et al. Cancer Med, 2023 Jul. PMID 37260179, Free PMC Article
    2. Light chains of mammalian cytoplasmic dynein: identification and characterization of a family of LC8 light chains. Wilson MJ, et al. Cell Motil Cytoskeleton, 2001 Aug. PMID 11746667
    3. Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex. Roux AF, et al. Hum Mol Genet, 1994 Feb. PMID 8004092
    4. Cytoplasmic dynein contains a family of differentially expressed light chains. King SM, et al. Biochemistry, 1998 Oct 27. PMID 9790665
    5. Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway. Yeh TY, et al. J Cell Sci, 2005 Aug 1. PMID 16079286

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The role of DYNLT3 in breast cancer proliferation, migration, and invasion via epithelial-to-mesenchymal transition.
      Title: The role of DYNLT3 in breast cancer proliferation, migration, and invasion via epithelial-to-mesenchymal transition.
    2. Age-associated genes in human mammary gland drive human breast cancer progression.
      Title: Age-associated genes in human mammary gland drive human breast cancer progression.
    3. These data show that both DYNLT1 and DYNLT3 interact with L2 of human papillomavirus 16 during virus infection.
      Title: Identification of the dynein light chains required for human papillomavirus infection.
    4. The N-terminal half of pUL35, in particular residues 30-43, was identified as a common region for the binding of DYNLT1 and DYNLT3.
      Title: Identification of binding domains in the herpes simplex virus type 1 small capsid protein pUL35 (VP26).
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitotic spindle astral microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein light chain Tctex-type 3
    Names
    protein 91/23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016797.1 RefSeqGene

      Range
      5066..13801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006520.3 → NP_006511.1  dynein light chain Tctex-type 3

      See identical proteins and their annotated locations for NP_006511.1

      Status: REVIEWED

      Source sequence(s)
      BC000968, DA342302
      Consensus CDS
      CCDS14243.1
      UniProtKB/Swiss-Prot
      P51808, Q6ICS3
      UniProtKB/TrEMBL
      F2Z328
      Related
      ENSP00000367841.4, ENST00000378578.9
      Conserved Domains (1) summary
      cd21463
      Location:16 → 112
      DLC-like_DYNLT3; dynein light chain (DLC)-like domain found in dynein light chain Tctex-type 3 (DYNLT3) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      37838836..37847571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      37242419..37251154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51808.1 GenPept UniProtKB/Swiss-Prot:P51808

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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