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    ARHGAP32 Rho GTPase activating protein 32 [ Homo sapiens (human) ]

    Gene ID: 9743, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ARHGAP32provided by HGNC
    Official Full Name
    Rho GTPase activating protein 32provided by HGNC
    Primary source
    HGNC:HGNC:17399
    See related
    Ensembl:ENSG00000134909 MIM:608541; AllianceGenome:HGNC:17399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GRIT; RICS; GC-GAP; PX-RICS; p250GAP; p200RhoGAP
    Summary
    RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in brain (RPKM 12.5), esophagus (RPKM 7.8) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARHGAP32 in Genome Data Viewer
    Location:
    11q24.3
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (128965060..129279632, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (128999975..129315124, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (128834955..129149413, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:128771525-128772283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4065 Neighboring gene KCNJ5 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:128796283-128797283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5745 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5746 Neighboring gene potassium inwardly rectifying channel subfamily J member 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128808070-128808570 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128808571-128809071 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128810609-128811109 Neighboring gene tumor protein p53 regulated apoptosis inducing protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128840383-128840884 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:128840885-128841384 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:128868598-128869797 Neighboring gene RNA, U6 small nuclear 876, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:128931012-128932211 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:129012637-129013836 Neighboring gene RNA, U6 small nuclear 874, pseudogene Neighboring gene uncharacterized LOC399975 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:129122522-129123022 Neighboring gene HNF4 motif-containing MPRA enhancer 230 Neighboring gene NANOG hESC enhancer GRCh37_chr11:129152926-129153427 Neighboring gene uncharacterized LOC124902791 Neighboring gene zinc finger protein 123, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits. Ohi K, et al. PLoS One, 2012. PMID 22530067, Free PMC Article
    2. Association between Grit and depressive symptoms at the timing of job start among medical residents during the COVID-19 pandemic in Japan: a cross-sectional study. Akaishi Y, et al. Med Educ Online, 2023 Dec. PMID 37343594, Free PMC Article
    3. Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis. Gardiner EM, et al. Curr Biol, 2002 Dec 10. PMID 12477392
    4. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Wayman GA, et al. Proc Natl Acad Sci U S A, 2008 Jul 1. PMID 18577589, Free PMC Article
    5. p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. Taniguchi S, et al. Biochem Biophys Res Commun, 2003 Jun 20. PMID 12788081

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association between Grit and depressive symptoms at the timing of job start among medical residents during the COVID-19 pandemic in Japan: a cross-sectional study.
      Title: Association between Grit and depressive symptoms at the timing of job start among medical residents during the COVID-19 pandemic in Japan: a cross-sectional study.
    2. Circ_ARHGAP32 acts as miR-665 sponge to upregulate FGF2 to promote ox-LDL induced vascular smooth muscle cells proliferation and migration.
      Title: Circ_ARHGAP32 acts as miR-665 sponge to upregulate FGF2 to promote ox-LDL induced vascular smooth muscle cells proliferation and migration.
    3. Cdh1-APC together with the RhoA regulators p250GAP and Smurf1 controls axon growth in the mammalian brain
      Title: p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation.
    4. the p250GAP gene might be a new candidate gene for susceptibility to schizophrenia.
      Title: The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits.
    5. The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum.
      Title: The PX-RICS-14-3-3zeta/theta complex couples N-cadherin-beta-catenin with dynein-dynactin to mediate its export from the endoplasmic reticulum.
    6. Results suggest that a splice variant of RICS, PX-RICS, is involved in early brain development including extension of axons and dendrites, and postnatal remodeling and fine-tuning of neural circuits.
      Title: PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development.
    7. miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity.
      Title: An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
    8. Results suggest that PX-RICS ensures the efficient entry of the N-cadherin/beta-catenin complex into the secretory pathway, and thereby regulates the amount of N-cadherin available for cell adhesion and FGFR4-mediated signaling.
      Title: PX-RICS mediates ER-to-Golgi transport of the N-cadherin/beta-catenin complex.
    9. These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases.
      Title: Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.
    10. is phosphorylated by Fyn in oligodendrocytes
      Title: p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of Rho GTPase activating protein 32 (ARHGAP32; RICS) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC1892, KIAA0712

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    		  
    enables phosphatidylinositol phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    		  
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fibrillar center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 32
    Names
    GAB-associated CDC42
    GAB-associated Cdc42/Rac GTPase-activating protein
    GTPase regulator interacting with TrkA
    GTPase-activating protein for Cdc42 and Rac1
    RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaling
    brain-specific Rho GTP-ase-activating protein
    brain-specific Rho GTPase-activating protein
    rac GTPase activating protein
    rho-type GTPase-activating protein 32
    rho/Cdc42/Rac GTPase-activating protein RICS
    rhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142685.2 → NP_001136157.1  rho GTPase-activating protein 32 isoform 1

      See identical proteins and their annotated locations for NP_001136157.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1). This isoform is also known as PX-RICS.
      Source sequence(s)
      AP000747, AP000751, AP002886
      Consensus CDS
      CCDS44769.1
      UniProtKB/Swiss-Prot
      A7KAX9, I7H0B0, O94820, Q86YL6, Q8IUG4, Q9BWG3
      UniProtKB/TrEMBL
      A0A2X0SFD0
      Related
      ENSP00000310561.8, ENST00000310343.13
      Conserved Domains (3) summary
      cd07298
      Location:127 → 241
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:263 → 316
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:368 → 562
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

    2. NM_001378024.1 → NP_001364953.1  rho GTPase-activating protein 32 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AP000747, AP000751, AP002886
      Consensus CDS
      CCDS91623.1
      UniProtKB/TrEMBL
      A0A2X0SFD0, A0A804HK06
      Related
      ENSP00000507720.1, ENST00000682385.1
      Conserved Domains (3) summary
      cd07298
      Location:141 → 255
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:277 → 330
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:382 → 576
      RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

    3. NM_001378025.1 → NP_001364954.1  rho GTPase-activating protein 32 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AP000747, AP000751, AP002886
      UniProtKB/TrEMBL
      A0A2X0SFD0
      Conserved Domains (3) summary
      cd07298
      Location:87 → 201
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:223 → 276
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:328 → 522
      RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

    4. NM_014715.4 → NP_055530.2  rho GTPase-activating protein 32 isoform 2

      See identical proteins and their annotated locations for NP_055530.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks multiple exons in the 5' UTR and 5' coding region and has a unique exon for its 5' UTR, compared to variant 1. These differences cause translation initiation from a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus which lacks phox homology and src homology 3 domains, compared to isoform 1.
      Source sequence(s)
      AB079856, AP000751, BQ319051, EF127492
      Consensus CDS
      CCDS31718.1
      UniProtKB/TrEMBL
      A0A2X0SFD0
      Related
      ENSP00000376425.3, ENST00000392657.7
      Conserved Domains (1) summary
      cd04384
      Location:19 → 213
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      128965060..129279632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047427929.1 → XP_047283885.1  rho GTPase-activating protein 32 isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFD0

    2. XM_047427927.1 → XP_047283883.1  rho GTPase-activating protein 32 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFD0

    3. XM_047427926.1 → XP_047283882.1  rho GTPase-activating protein 32 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFD0

    4. XM_047427930.1 → XP_047283886.1  rho GTPase-activating protein 32 isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFD0

    5. XM_017018595.3 → XP_016874084.1  rho GTPase-activating protein 32 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFD0
      Conserved Domains (3) summary
      cd07298
      Location:101 → 215
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:237 → 290
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:342 → 536
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

    6. XM_011543072.3 → XP_011541374.1  rho GTPase-activating protein 32 isoform X2

      See identical proteins and their annotated locations for XP_011541374.1

      UniProtKB/TrEMBL
      A0A2X0SFD0
      Conserved Domains (3) summary
      cd07298
      Location:101 → 215
      PX_RICS; The phosphoinositide binding Phox Homology domain of PX-RICS
      cd11835
      Location:237 → 290
      SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins
      cd04384
      Location:342 → 536
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

    7. XM_047427928.1 → XP_047283884.1  rho GTPase-activating protein 32 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SFD0

    8. XM_011543073.3 → XP_011541375.2  rho GTPase-activating protein 32 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFD0

    9. XM_017018596.2 → XP_016874085.1  rho GTPase-activating protein 32 isoform X7

      UniProtKB/TrEMBL
      A0A2X0SFD0

    10. XM_011543075.3 → XP_011541377.1  rho GTPase-activating protein 32 isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFD0
      Conserved Domains (1) summary
      cd04384
      Location:43 → 237
      RhoGAP_CdGAP; RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP ...

    11. XM_017018597.3 → XP_016874086.1  rho GTPase-activating protein 32 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      128999975..129315124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370623.1 → XP_054226598.1  rho GTPase-activating protein 32 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFD0

    2. XM_054370625.1 → XP_054226600.1  rho GTPase-activating protein 32 isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFD0

    3. XM_054370620.1 → XP_054226595.1  rho GTPase-activating protein 32 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFD0

    4. XM_054370626.1 → XP_054226601.1  rho GTPase-activating protein 32 isoform X4

      UniProtKB/TrEMBL
      A0A2X0SFD0

    5. XM_054370621.1 → XP_054226596.1  rho GTPase-activating protein 32 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFD0

    6. XM_054370622.1 → XP_054226597.1  rho GTPase-activating protein 32 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SFD0

    7. XM_054370624.1 → XP_054226599.1  rho GTPase-activating protein 32 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SFD0

    8. XM_054370619.1 → XP_054226594.1  rho GTPase-activating protein 32 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SFD0

    9. XM_054370627.1 → XP_054226602.1  rho GTPase-activating protein 32 isoform X5

      UniProtKB/TrEMBL
      A0A2X0SFD0

    10. XM_054370628.1 → XP_054226603.1  rho GTPase-activating protein 32 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A7KAX9.1 GenPept UniProtKB/Swiss-Prot:A7KAX9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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