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    CDK14 cyclin dependent kinase 14 [ Homo sapiens (human) ]

    Gene ID: 5218, updated on 14-Nov-2024

    Summary

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    Official Symbol
    CDK14provided by HGNC
    Official Full Name
    cyclin dependent kinase 14provided by HGNC
    Primary source
    HGNC:HGNC:8883
    See related
    Ensembl:ENSG00000058091 MIM:610679; AllianceGenome:HGNC:8883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PFTK1; PFTAIRE1
    Summary
    Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in G2/M transition of mitotic cell cycle and regulation of canonical Wnt signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of cytoplasmic cyclin-dependent protein kinase holoenzyme complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 6.5), kidney (RPKM 3.1) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CDK14 in Genome Data Viewer
    Location:
    7q21.13
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (90596321..91210590)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (91844591..92458441)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (90225635..90839905)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:90032955-90033480 Neighboring gene Sharpr-MPRA regulatory region 3343 Neighboring gene Sharpr-MPRA regulatory region 14602 Neighboring gene claudin 12 Neighboring gene uncharacterized LOC124901693 Neighboring gene PTTG1IP family member 2 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:90208498-90209697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18360 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18361 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26246 Neighboring gene small nucleolar RNA U13 Neighboring gene MPRA-validated peak6628 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26247 Neighboring gene TVP23C pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26250 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26251 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:90395797-90396298 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:90394025-90394596 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:90396299-90396798 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26252 Neighboring gene uncharacterized LOC124901694 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:90661021-90661555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:90690954-90691454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:90691455-90691955 Neighboring gene VISTA enhancer hs1627 Neighboring gene VISTA enhancer hs1628 Neighboring gene VISTA enhancer hs1633 Neighboring gene PTP4A1 pseudogene 3 Neighboring gene VISTA enhancer hs1631 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18363 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18364 Neighboring gene uncharacterized LOC124901695 Neighboring gene frizzled class receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Upregulated PFTK1 promotes tumor cell proliferation, migration, and invasion in breast cancer. Gu X, et al. Med Oncol, 2015 Jul. PMID 26033031
    2. Knockdown of PFTK1 Expression by RNAi Inhibits the Proliferation and Invasion of Human Non-Small Lung Adenocarcinoma Cells. Liu MH, et al. Oncol Res, 2016. PMID 27458099, Free PMC Article
    3. Knockdown of PFTAIRE Protein Kinase 1 (PFTK1) Inhibits Proliferation, Invasion, and EMT in Colon Cancer Cells. Zhu J, et al. Oncol Res, 2016. PMID 27458094, Free PMC Article
    4. High expression of PFTK1 in cancer cells predicts poor prognosis in colorectal cancer. Mao Y, et al. Mol Med Rep, 2017 Jul. PMID 28498444
    5. Knockdown of PFTK1 inhibits tumor cell proliferation, invasion and epithelial-to-mesenchymal transition in pancreatic cancer. Zheng L, et al. Int J Clin Exp Pathol, 2015. PMID 26823712, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N6-methyladenosine-modified circCDK14 promotes ossification of the ligamentum flavum via epigenetic modulation by targeting AFF4.
      Title: N6-methyladenosine-modified circCDK14 promotes ossification of the ligamentum flavum via epigenetic modulation by targeting AFF4.
    2. Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
      Title: Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy.
    3. P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC.
      Title: P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC.
    4. LncRNA NORAD accelerates the progression of non-small cell lung cancer via targeting miRNA-455/CDK14 axis.
      Title: LncRNA NORAD accelerates the progression of non-small cell lung cancer via targeting miRNA-455/CDK14 axis.
    5. CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA.
      Title: CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA.
    6. Depletion of circRNA circ_CDK14 inhibits osteosarcoma progression by regulating the miR-520a-3p/GAB1 axis.
      Title: Depletion of circRNA circ_CDK14 inhibits osteosarcoma progression by regulating the miR-520a-3p/GAB1 axis.
    7. MiR-205 Inhibits Sporadic Vestibular Schwannoma Cell Proliferation by Targeting Cyclin-Dependent Kinase 14.
      Title: MiR-205 Inhibits Sporadic Vestibular Schwannoma Cell Proliferation by Targeting Cyclin-Dependent Kinase 14.
    8. CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2.
      Title: CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2.
    9. Upregulation of miR-1825 inhibits the progression of glioblastoma by suppressing CDK14 though Wnt/beta-catenin signaling pathway.
      Title: Upregulation of miR-1825 inhibits the progression of glioblastoma by suppressing CDK14 though Wnt/β-catenin signaling pathway.
    10. we demonstrated that MSC-AS1/miR-29b-3p axis modulates the cell proliferation and GEM-induced cell apoptosis in PDAC cell lines through CDK14. We provided a novel experimental basis for PDAC treatment from the perspective of lncRNA-miRNA-mRNA network.
      Title: The role of lncRNA MSC-AS1/miR-29b-3p axis-mediated CDK14 modulation in pancreatic cancer proliferation and Gemcitabine-induced apoptosis.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic Variants Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European Americans and African Americans from the eMERGE Network.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat specifically associates with CDK14 promoter to upregulate CDK14 expression in T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0834

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-dependent kinase 14
    Names
    PFTAIRE protein kinase 1
    cell division protein kinase 14
    serine/threonine-protein kinase PFTAIRE-1
    NP_001274064.1
    NP_001274065.1
    NP_001274066.1
    NP_036527.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287135.2 → NP_001274064.1  cyclin-dependent kinase 14 isoform a

      See identical proteins and their annotated locations for NP_001274064.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AB020641, AC002456, AF119833, AK297974, BC136477, BC152436, BM740394, BP336072, DB476188, DC420282, HY179664
      Consensus CDS
      CCDS75626.1
      UniProtKB/Swiss-Prot
      A4D1E6, A6NK51, A8WFP6, B4DHG5, B4DNM2, O94921, Q75N06, Q75N22, Q8N764, Q9H3D7, Q9UDR0
      Related
      ENSP00000369390.3, ENST00000380050.8
      Conserved Domains (1) summary
      cd07869
      Location:129 → 431
      STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

    2. NM_001287136.1 → NP_001274065.1  cyclin-dependent kinase 14 isoform c

      See identical proteins and their annotated locations for NP_001274065.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AB020641, AK295086, AK316026, BC136477, BC152436, BM740394, BP336072, DB476188, DC325068
      Consensus CDS
      CCDS75627.1
      UniProtKB/Swiss-Prot
      O94921
      Related
      ENSP00000385034.1, ENST00000406263.5
      Conserved Domains (1) summary
      cd07869
      Location:83 → 385
      STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase

    3. NM_001287137.1 → NP_001274066.1  cyclin-dependent kinase 14 isoform d

      See identical proteins and their annotated locations for NP_001274066.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate 5' exon structure and it thus differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AB020641, AK296406, AK316026, BC136477, BC152436, BM740394, BP336072, DB476188, DC325068
      Consensus CDS
      CCDS75628.1
      UniProtKB/TrEMBL
      B4DK59, E7EUK8
      Related
      ENSP00000398936.2, ENST00000436577.3
      Conserved Domains (1) summary
      cl21453
      Location:25 → 302
      PKc_like; Protein Kinases, catalytic domain

    4. NM_012395.3 → NP_036527.1  cyclin-dependent kinase 14 isoform b

      See identical proteins and their annotated locations for NP_036527.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate 5' exon structure and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AB020641, BC136477, BC152436, BM740394, BP336072, DB476188
      Consensus CDS
      CCDS5619.1
      UniProtKB/Swiss-Prot
      O94921
      Related
      ENSP00000265741.3, ENST00000265741.7
      Conserved Domains (2) summary
      cd07869
      Location:111 → 413
      STKc_PFTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase
      PLN00009
      Location:115 → 404
      PLN00009; cyclin-dependent kinase A; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      90596321..91210590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      91844591..92458441
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O94921.3 GenPept UniProtKB/Swiss-Prot:O94921

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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