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    TNK1 tyrosine kinase non receptor 1 [ Homo sapiens (human) ]

    Gene ID: 8711, updated on 26-Nov-2024

    Summary

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    Official Symbol
    TNK1provided by HGNC
    Official Full Name
    tyrosine kinase non receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:11940
    See related
    Ensembl:ENSG00000174292 MIM:608076; AllianceGenome:HGNC:11940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOS1
    Summary
    The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Ubiquitous expression in stomach (RPKM 6.3), duodenum (RPKM 4.1) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TNK1 in Genome Data Viewer
    Location:
    17p13.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (7380047..7389742)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (7285126..7293784)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7284408..7293061)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8113 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7258016-7258542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:7258543-7259069 Neighboring gene potassium channel tetramerization domain containing 11 Neighboring gene transmembrane protein 95 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:7269638-7269860 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:7283926-7284426 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8114 Neighboring gene TMEM256-PLSCR3 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8115 Neighboring gene phospholipid scramblase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8116 Neighboring gene transmembrane protein 256 Neighboring gene neuroligin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:7323127-7323646

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain. Nawarathnage S, et al. Structure, 2023 Dec 7. PMID 37776857,
    2. High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells. Henderson MC, et al. Mol Cancer Res, 2011 Jun. PMID 21536687, Free PMC Article
    3. Identification of activated Tnk1 kinase in Hodgkin's lymphoma. Gu TL, et al. Leukemia, 2010 Apr. PMID 20090780
    4. Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock. Halbgebauer R, et al. Front Immunol, 2020. PMID 32983160, Free PMC Article
    5. Polymorphism rs11867353 of Tyrosine Kinase Non-Receptor 1 (TNK1) Gene Is a Novel Genetic Marker for Alzheimer's Disease. Zeman T, et al. Mol Neurobiol, 2021 Mar. PMID 33070267

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain.
      Title: Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain.
    2. The noncatalytic regions of the tyrosine kinase Tnk1 are important for activity and substrate specificity.
      Title: The noncatalytic regions of the tyrosine kinase Tnk1 are important for activity and substrate specificity.
    3. Polymorphism rs11867353 of Tyrosine Kinase Non-Receptor 1 (TNK1) Gene Is a Novel Genetic Marker for Alzheimer's Disease.
      Title: Polymorphism rs11867353 of Tyrosine Kinase Non-Receptor 1 (TNK1) Gene Is a Novel Genetic Marker for Alzheimer's Disease.
    4. TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.
      Title: TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.
    5. Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock.
      Title: Thirty-Eight-Negative Kinase 1 Is a Mediator of Acute Kidney Injury in Experimental and Clinical Traumatic Hemorrhagic Shock.
    6. TNK1 was found to be deregulated in the gut in murine and porcine trauma models and human inflammatory bowel disease. Thus, TNK1 might be a target during MODS to prevent damage in several organs, notably the gut.
      Title: Thirty-eight-negative kinase 1 mediates trauma-induced intestinal injury and multi-organ failure.
    7. the Single nucleotide polymorphisms rs11136000 of CLU, rs541458 of PICALM, and rs1554948 of TNK1 according to the three age groups 50-65 years (group 1), 66-80 years (group 2), and 80+ years (group 3) in 569 older subjects without cognitive impairment (NoCI) and 520 Alzheimer's disease (AD) patients, were studied.
      Title: Role of CLU, PICALM, and TNK1 Genotypes in Aging With and Without Alzheimer's Disease.
    8. The activated TNK1 potentiates JAK-STAT signaling through dual phosphorylation of STAT1 at tyrosine 701 and serine 727 amino acid positions.
      Title: Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1.
    9. The application of functional genomics by using high-throughput-RNAi screens has allowed us to identify TNK1 as a growth-associated kinase in pancreatic cancer cells.
      Title: High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells.
    10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of tyrosine kinase, non-receptor, 1 (TNK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    non-receptor tyrosine-protein kinase TNK1
    Names
    CD38 negative kinase 1
    NP_001238831.1
    NP_003976.2
    XP_011522347.1
    XP_011522348.1
    XP_011522349.1
    XP_011522350.1
    XP_054173634.1
    XP_054173635.1
    XP_054173636.1
    XP_054188002.1
    XP_054188003.1
    XP_054188004.1
    XP_054188005.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001251902.3 → NP_001238831.1  non-receptor tyrosine-protein kinase TNK1 isoform 1

      See identical proteins and their annotated locations for NP_001238831.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC113189
      Consensus CDS
      CCDS58510.1
      UniProtKB/Swiss-Prot
      O95364, Q13470, Q8IYI4
      Related
      ENSP00000459799.1, ENST00000576812.5
      Conserved Domains (6) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:119 → 377
      STYKc; Protein kinase; unclassified specificity
      smart00326
      Location:385 → 441
      SH3; Src homology 3 domains
      cd14328
      Location:624 → 663
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cl21453
      Location:120 → 379
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:594 → 637
      UBA_like_SF; UBA domain-like superfamily

    2. NM_003985.6 → NP_003976.2  non-receptor tyrosine-protein kinase TNK1 isoform 2

      See identical proteins and their annotated locations for NP_003976.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site at an internal coding exon compared to variant 1. This results in a shorter isoform (2) missing a 5 aa protein segment compared to isoform 1.
      Source sequence(s)
      AC113189
      Consensus CDS
      CCDS45602.1
      UniProtKB/Swiss-Prot
      Q13470
      Related
      ENSP00000509611.1, ENST00000688331.1
      Conserved Domains (6) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:119 → 377
      STYKc; Protein kinase; unclassified specificity
      cd14328
      Location:619 → 658
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cl17036
      Location:396 → 435
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:120 → 379
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:589 → 632
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      7380047..7389742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524045.3 → XP_011522347.1  non-receptor tyrosine-protein kinase TNK1 isoform X1

      See identical proteins and their annotated locations for XP_011522347.1

      UniProtKB/Swiss-Prot
      Q13470
      Conserved Domains (6) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:119 → 377
      STYKc; Protein kinase; unclassified specificity
      cd14328
      Location:619 → 658
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cl17036
      Location:396 → 435
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:120 → 379
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:589 → 632
      UBA_like_SF; UBA domain-like superfamily

    2. XM_011524047.4 → XP_011522349.1  non-receptor tyrosine-protein kinase TNK1 isoform X3

      UniProtKB/TrEMBL
      G9BXQ3
      Conserved Domains (4) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:119 → 377
      STYKc; Protein kinase; unclassified specificity
      cl17036
      Location:396 → 435
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:120 → 379
      PKc_like; Protein Kinases, catalytic domain

    3. XM_011524046.4 → XP_011522348.1  non-receptor tyrosine-protein kinase TNK1 isoform X2

      Conserved Domains (6) summary
      cd09539
      Location:6 → 67
      SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
      smart00221
      Location:119 → 377
      STYKc; Protein kinase; unclassified specificity
      cd14328
      Location:617 → 656
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cl17036
      Location:396 → 435
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:120 → 379
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:587 → 630
      UBA_like_SF; UBA domain-like superfamily

    4. XM_011524048.2 → XP_011522350.1  non-receptor tyrosine-protein kinase TNK1 isoform X4

      Conserved Domains (4) summary
      cd14328
      Location:462 → 501
      UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
      cl17036
      Location:239 → 278
      SH3; Src Homology 3 domain superfamily
      cl21453
      Location:7 → 222
      PKc_like; Protein Kinases, catalytic domain
      cl21463
      Location:432 → 475
      UBA_like_SF; UBA domain-like superfamily

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_016107299.1 Reference GRCh38.p14 PATCHES

      Range
      504..10199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332027.1 → XP_054188002.1  non-receptor tyrosine-protein kinase TNK1 isoform X1

    2. XM_054332029.1 → XP_054188004.1  non-receptor tyrosine-protein kinase TNK1 isoform X3

    3. XM_054332028.1 → XP_054188003.1  non-receptor tyrosine-protein kinase TNK1 isoform X2

    4. XM_054332030.1 → XP_054188005.1  non-receptor tyrosine-protein kinase TNK1 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      7285126..7293784
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317660.1 → XP_054173635.1  non-receptor tyrosine-protein kinase TNK1 isoform X3

    2. XM_054317659.1 → XP_054173634.1  non-receptor tyrosine-protein kinase TNK1 isoform X2

    3. XM_054317661.1 → XP_054173636.1  non-receptor tyrosine-protein kinase TNK1 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13470.3 GenPept UniProtKB/Swiss-Prot:Q13470

    Gene LinkOut

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