U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 9645, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    MICAL2provided by HGNC
    Official Full Name
    microtubule associated monooxygenase, calponin and LIM domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:24693
    See related
    Ensembl:ENSG00000133816 MIM:608881; AllianceGenome:HGNC:24693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MICAL-2; MICALCL; Ebitein1; mical-cL; MICAL2PV1; MICAL2PV2
    Summary
    The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016]
    Expression
    Broad expression in testis (RPKM 23.1), colon (RPKM 17.9) and 24 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MICAL2 in Genome Data Viewer
    Location:
    11p15.3
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (12110590..12362140)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (12202447..12454129)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (12132137..12383687)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2547 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:12087483-12088682 Neighboring gene Sharpr-MPRA regulatory region 886 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12114457-12114957 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:12125283-12125783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12132043-12132746 Neighboring gene long intergenic non-protein coding RNA 2989 Neighboring gene GATA motif-containing MPRA enhancer 176/177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12158230-12158730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12160461-12161004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12161005-12161546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12184971-12185470 Neighboring gene Sharpr-MPRA regulatory region 10887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12200287-12201161 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12203881-12204381 Neighboring gene Sharpr-MPRA regulatory region 12121 Neighboring gene microRNA 6124 Neighboring gene uncharacterized LOC124902634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12238418-12238918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12238919-12239419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12263505-12264029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12352017-12352518 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:12387753-12388325 Neighboring gene parvin alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:12474119-12474620 Neighboring gene Sharpr-MPRA regulatory region 15612/8581 Neighboring gene Sharpr-MPRA regulatory region 1666 Neighboring gene uncharacterized LOC105376556 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12658187-12658688 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:12658689-12659188

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. MICAL2 implies immunosuppressive features and acts as an independent and adverse prognostic biomarker in pancreatic cancer. Liu Z, et al. Sci Rep, 2024 Feb 7. PMID 38326344, Free PMC Article
    2. MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion. Mariotti S, et al. Oncotarget, 2016 Jan 12. PMID 26689989, Free PMC Article
    3. MICAL2 promotes breast cancer cell migration by maintaining epidermal growth factor receptor (EGFR) stability and EGFR/P38 signalling activation. Wang Y, et al. Acta Physiol (Oxf), 2018 Feb. PMID 28719045
    4. MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response. Barravecchia I, et al. Biochim Biophys Acta Mol Basis Dis, 2019 Sep 1. PMID 31004710
    5. MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma. Zhou W, et al. Cancer Lett, 2020 Jul 28. PMID 32360180

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MICAL2 implies immunosuppressive features and acts as an independent and adverse prognostic biomarker in pancreatic cancer.
      Title: MICAL2 implies immunosuppressive features and acts as an independent and adverse prognostic biomarker in pancreatic cancer.
    2. MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/beta-catenin signaling pathway.
      Title: MICAL2 contributes to gastric cancer cell migration via Cdc42-dependent activation of E-cadherin/β-catenin signaling pathway.
    3. MICAL2 Contributes to Gastric Cancer Cell Proliferation by Promoting YAP Dephosphorylation and Nuclear Translocation.
      Title: MICAL2 Contributes to Gastric Cancer Cell Proliferation by Promoting YAP Dephosphorylation and Nuclear Translocation.
    4. MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes.
      Title: MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes.
    5. MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.
      Title: MICAL2PV suppresses the formation of tunneling nanotubes and modulates mitochondrial trafficking.
    6. MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma.
      Title: MICAL2 is a novel nucleocytoplasmic shuttling protein promoting cancer invasion and growth of lung adenocarcinoma.
    7. MICAL2 expression in endothelial cells participates to inflammation-induced neo-angiogenesis and that MICAL2 inhibition should be tested in cancer- and noncancer-associated neo-angiogenesis, where chronic inflammation represents a relevant pathophysiological mechanism.
      Title: MICAL2 is expressed in cancer associated neo-angiogenic capillary endothelia and it is required for endothelial cell viability, motility and VEGF response.
    8. MICAL2 is a major regulator of breast cancer cell migration
      Title: MICAL2 promotes breast cancer cell migration by maintaining epidermal growth factor receptor (EGFR) stability and EGFR/P38 signalling activation.
    9. In pulmonary artery hypertension miR-205-5p suppressed pulmonary artery smooth muscle cell proliferation by targeting MICAL2, which activated ERK1/2 signaling.
      Title: miR-205-5p suppresses pulmonary vascular smooth muscle cell proliferation by targeting MICAL2-mediated Erk1/2 signaling.
    10. Data suggest that MICAL2 protein might be an important regulator of epithelial to mesenchymal transition and therefore a promising target for anti-metastatic therapy.
      Title: MICAL2 is a novel human cancer gene controlling mesenchymal to epithelial transition involved in cancer growth and invasion.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • FLJ14966, FLJ21533, FLJ22463, FLJ33231, FLJ41677, FLJ43564, FLJ43797, KIAA0750, MGC195878, DKFZp686H2469, DKFZp686H03148

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables F-actin monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables NAD(P)H oxidase H2O2-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mitogen-activated protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heart looping ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    [F-actin]-monooxygenase MICAL2
    Names
    ERK2-binding testicular protein 1
    MICAL C-terminal like
    MICAL C-terminal-like protein
    [F-actin]-methionine sulfoxide oxidase MICAL2
    ebitein-1
    flavoprotein oxidoreductase MICAL2
    microtubule associated monoxygenase, calponin and LIM domain containing 2
    molecule interacting with CasL protein 2
    protein-methionine sulfoxide oxidase MICAL2
    NP_001269592.1
    NP_001269593.1
    NP_001269594.1
    NP_001269595.1
    NP_001269596.1
    NP_001269597.1
    NP_001333221.1
    NP_001333222.1
    NP_001333223.1
    NP_001333224.1
    NP_001333225.1
    NP_001333226.1
    NP_001333227.1
    NP_001333228.1
    NP_001380866.1
    NP_055447.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051801.2 RefSeqGene

      Range
      5002..158197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282663.2 → NP_001269592.1  [F-actin]-monooxygenase MICAL2 isoform a

      See identical proteins and their annotated locations for NP_001269592.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 8 all encode isoform a.
      Source sequence(s)
      AB018293, AK294845, DA246062
      Consensus CDS
      CCDS7809.1
      UniProtKB/Swiss-Prot
      O94851
      Related
      ENSP00000507067.1, ENST00000683283.1
      Conserved Domains (4) summary
      cd09439
      Location:1002 → 1056
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:522 → 617
      CH; Calponin homology (CH) domain
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      cl21454
      Location:78 → 121
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001282664.1 → NP_001269593.1  [F-actin]-monooxygenase MICAL2 isoform b

      See identical proteins and their annotated locations for NP_001269593.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a portion of the 5' UTR, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 9-15 all encode the same isoform (b).
      Source sequence(s)
      AK294845, AL046982, BC044577, DA246062
      Consensus CDS
      CCDS60726.1
      UniProtKB/Swiss-Prot
      O94851
      Related
      ENSP00000502351.1, ENST00000675839.1
      Conserved Domains (4) summary
      cd09439
      Location:981 → 1035
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:522 → 617
      CH; Calponin homology (CH) domain
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      cl21454
      Location:78 → 121
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. NM_001282665.1 → NP_001269594.1  [F-actin]-monooxygenase MICAL2 isoform c

      See identical proteins and their annotated locations for NP_001269594.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks a portion of the 5' UTR, lacks four exons that result in the loss of an in-frame segment in the central coding region, and differs in the 3' UTR, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AK294845, AK302893, AL046982, BC048206, BG939697
      Consensus CDS
      CCDS60727.1
      UniProtKB/Swiss-Prot
      O94851
      Related
      ENSP00000433965.1, ENST00000527546.5
      Conserved Domains (4) summary
      cd09439
      Location:812 → 866
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:522 → 617
      CH; Calponin homology (CH) domain
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      cl21454
      Location:78 → 121
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    4. NM_001282666.1 → NP_001269595.1  [F-actin]-monooxygenase MICAL2 isoform d

      See identical proteins and their annotated locations for NP_001269595.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks a portion of the 5' UTR, lacks four exons that result in the loss of an in-frame segment in the central coding region, and has multiple differences in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AB110785, AK294845, AK302893, AL046982, BC048206, BG939697, BX641163
      UniProtKB/Swiss-Prot
      O94851
      Related
      ENSP00000516723.1, ENST00000707072.1
      Conserved Domains (4) summary
      cd09439
      Location:776 → 830
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:522 → 617
      CH; Calponin homology (CH) domain
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      cl21454
      Location:78 → 121
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    5. NM_001282667.1 → NP_001269596.1  [F-actin]-monooxygenase MICAL2 isoform e

      See identical proteins and their annotated locations for NP_001269596.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks a portion of the 5' UTR, lacks six exons that result in the loss of an in-frame segment in the central coding region, and has multiple differences in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AB110786, AK294845, AK302893, AL046982, BC048206, BG939697, BX641163
      Consensus CDS
      CCDS91443.1
      UniProtKB/Swiss-Prot
      O94851
      Related
      ENSP00000499778.1, ENST00000528931.5
      Conserved Domains (4) summary
      cd09439
      Location:755 → 809
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:522 → 617
      CH; Calponin homology (CH) domain
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      cl21454
      Location:78 → 121
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    6. NM_001282668.2 → NP_001269597.1  [F-actin]-monooxygenase MICAL2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses an alternate splice site in the 5' UTR, and lacks several 3' exons but contains an alternate 3' terminal exon, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is significantly shorter than isoform a.
      Source sequence(s)
      BC015755, DA246062
      Related
      ENST00000531732.5
      Conserved Domains (1) summary
      pfam01494
      Location:87 → 141
      FAD_binding_3; FAD binding domain

    7. NM_001346292.2 → NP_001333221.1  [F-actin]-monooxygenase MICAL2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1 and 2, encodes isoform a.
      Source sequence(s)
      AC025106, AC079329
      Consensus CDS
      CCDS7809.1
      UniProtKB/Swiss-Prot
      O94851

    8. NM_001346293.2 → NP_001333222.1  [F-actin]-monooxygenase MICAL2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 3 and 10-15, encodes isoform b.
      Source sequence(s)
      AC025106, AC079329
      Consensus CDS
      CCDS60726.1
      UniProtKB/Swiss-Prot
      O94851

    9. NM_001346294.2 → NP_001333223.1  [F-actin]-monooxygenase MICAL2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 3, 9, and 11-15, encodes isoform b.
      Source sequence(s)
      AC025106, AC079329
      Consensus CDS
      CCDS60726.1
      UniProtKB/Swiss-Prot
      O94851

    10. NM_001346295.2 → NP_001333224.1  [F-actin]-monooxygenase MICAL2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 3, 9-10, and 12-15, encodes isoform b.
      Source sequence(s)
      AC025106, AC079329
      Consensus CDS
      CCDS60726.1
      UniProtKB/Swiss-Prot
      O94851

    11. NM_001346296.2 → NP_001333225.1  [F-actin]-monooxygenase MICAL2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 3, 9-11, and 13-15, encodes isoform b.
      Source sequence(s)
      AC025106, AC079329
      Consensus CDS
      CCDS60726.1
      UniProtKB/Swiss-Prot
      O94851

    12. NM_001346297.2 → NP_001333226.1  [F-actin]-monooxygenase MICAL2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 3, 9-12, and 14-15, encodes isoform b.
      Source sequence(s)
      AC025106, AC079329
      Consensus CDS
      CCDS60726.1
      UniProtKB/Swiss-Prot
      O94851

    13. NM_001346298.2 → NP_001333227.1  [F-actin]-monooxygenase MICAL2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 3, 9-13, and 15, encodes isoform b.
      Source sequence(s)
      AC025106, AC079329
      Consensus CDS
      CCDS60726.1
      UniProtKB/Swiss-Prot
      O94851

    14. NM_001346299.2 → NP_001333228.1  [F-actin]-monooxygenase MICAL2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 3 and 9-14, encodes isoform b.
      Source sequence(s)
      AC025106, AC079329
      Consensus CDS
      CCDS60726.1
      UniProtKB/Swiss-Prot
      O94851

    15. NM_001393937.1 → NP_001380866.1  [F-actin]-monooxygenase MICAL2 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC025106, AC025300, AC079329
      Consensus CDS
      CCDS91442.1
      UniProtKB/Swiss-Prot
      A0A2R8YFA9, B4DGZ0, B7Z849, D3DQW5, G3XAC8, O94851, Q5KTR3, Q5KTR4, Q6ZW33, Q7RTP7, Q7Z3A8, Q96JU6
      Related
      ENSP00000494982.1, ENST00000646065.1
      Conserved Domains (6) summary
      cd09439
      Location:1002 → 1056
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      smart00945
      Location:1628 → 1718
      ProQ; ProQ/FINO family
      smart00033
      Location:522 → 617
      CH; Calponin homology domain
      PHA03247
      Location:1087 → 1624
      PHA03247; large tegument protein UL36; Provisional
      cl30692
      Location:87 → 226
      UbiH; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme transport and metabolism, Energy production and conversion]
      pfam17380
      Location:1773 → 1944
      DUF5401; Family of unknown function (DUF5401)

    16. NM_014632.4 → NP_055447.1  [F-actin]-monooxygenase MICAL2 isoform a

      See identical proteins and their annotated locations for NP_055447.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, and 8 all encode isoform a.
      Source sequence(s)
      AK294845, BC044577, DA246062
      Consensus CDS
      CCDS7809.1
      UniProtKB/Swiss-Prot
      O94851
      Related
      ENSP00000256194.4, ENST00000256194.8
      Conserved Domains (4) summary
      cd09439
      Location:1002 → 1056
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:522 → 617
      CH; Calponin homology (CH) domain
      pfam01494
      Location:87 → 274
      FAD_binding_3; FAD binding domain
      cl21454
      Location:78 → 121
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. NR_144415.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC025106, AC079329

    2. NR_144416.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC025106, AC079329

    3. NR_144417.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC025106, AC079329

    4. NR_144418.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC025106, AC079329

    5. NR_144419.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC025106, AC079329

    6. NR_144420.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC025106, AC079329

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      12110590..12362140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      12202447..12454129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_032867.4: Suppressed sequence

      Description
      NM_032867.4: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O94851.2 GenPept UniProtKB/Swiss-Prot:O94851

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools