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    ZNF24 zinc finger protein 24 [ Homo sapiens (human) ]

    Gene ID: 7572, updated on 3-Nov-2024

    Summary

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    Official Symbol
    ZNF24provided by HGNC
    Official Full Name
    zinc finger protein 24provided by HGNC
    Primary source
    HGNC:HGNC:13032
    See related
    Ensembl:ENSG00000172466 MIM:194534; AllianceGenome:HGNC:13032
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX17; RSG-A; ZNF191; ZSCAN3; Zfp191
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 22.0), brain (RPKM 18.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF24 in Genome Data Viewer
    Location:
    18q12.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (35332227..35344420, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (35523566..35535760, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (32912191..32924384, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 397 Neighboring gene zinc finger and SCAN domain containing 30 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13222 Neighboring gene zinc finger protein 271, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32904859-32905554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13223 Neighboring gene uncharacterized LOC124904283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9396 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32934967-32935487 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:32936140-32936672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9398 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9399 Neighboring gene zinc finger protein 396 Neighboring gene ribosomal protein L7a pseudogene 67

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Tumor-suppressive zinc finger protein 24 (ZNF24) sensitizes colorectal cancer cells to 5-fluorouracil by inhibiting the Wnt pathway and activating the p53 signaling. Meng F, et al. Exp Cell Res, 2023 Dec 1. PMID 37774763
    2. Overexpression and purification of single zinc finger peptides of human zinc finger protein ZNF191. Zhao DX, et al. Protein Expr Purif, 2007 May. PMID 17270462
    3. A transcript profiling approach reveals the zinc finger transcription factor ZNF191 is a pleiotropic factor. Li J, et al. BMC Genomics, 2009 May 22. PMID 19463170, Free PMC Article
    4. Identification of a functional nuclear localization signal mediating nuclear import of the zinc finger transcription factor ZNF24. Li JZ, et al. PLoS One, 2013. PMID 24224020, Free PMC Article
    5. The endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells. Jia D, et al. FASEB J, 2015 Apr. PMID 25550468, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tumor-suppressive zinc finger protein 24 (ZNF24) sensitizes colorectal cancer cells to 5-fluorouracil by inhibiting the Wnt pathway and activating the p53 signaling.
      Title: Tumor-suppressive zinc finger protein 24 (ZNF24) sensitizes colorectal cancer cells to 5-fluorouracil by inhibiting the Wnt pathway and activating the p53 signaling.
    2. ZNF191 alters DNA methylation and activates the PI3K-AKT pathway in hepatoma cells via transcriptional regulation of DNMT1.
      Title: ZNF191 alters DNA methylation and activates the PI3K-AKT pathway in hepatoma cells via transcriptional regulation of DNMT1.
    3. Wnt8B, transcriptionally regulated by ZNF191, promotes cell proliferation of hepatocellular carcinoma via Wnt signaling.
      Title: Wnt8B, transcriptionally regulated by ZNF191, promotes cell proliferation of hepatocellular carcinoma via Wnt signaling.
    4. miR-940 promoted gastric cancer progression by directly downregulating ZNF24 expression.
      Title: MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer.
    5. In vivo, knockdown of ZNF24 specifically in microvascular endothelial cells led to significantly decreased formation of functional vascular networks.
      Title: The endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells.
    6. results suggest that consecutive ZF1-2 is critical for the regulation of ZNF24 nuclear localization and its transactivation function.
      Title: Identification of a functional nuclear localization signal mediating nuclear import of the zinc finger transcription factor ZNF24.
    7. ZNF24 represses VEGF transcription through direct binding to an 11-bp fragment of the VEGF proximal promoter and that it functions as a negative regulator of tumor growth by inhibiting angiogenesis.
      Title: Transcriptional repression of VEGF by ZNF24: mechanistic studies and vascular consequences in vivo.
    8. ZNF24 may be implicated in transcriptional regulation of genes associated with oncogenesis via interaction with H2A.Z.
      Title: A yeast two-hybrid screen identifies histone H2A.Z as a transcription factor ZNF24 interactor.
    9. ZNF191 can directly bind to the CTNNB1 promoter and activate the expression of beta-catenin and its downstream target genes such as cyclin D1 in hepatoma cell lines.
      Title: Zinc finger transcription factor 191, directly binding to β-catenin promoter, promotes cell proliferation of hepatocellular carcinoma.
    10. These data suggest that ZNF24 is involved in negative regulation of PDGFR-beta and may represent a novel repressor of PDGFR-beta transcription.
      Title: The transcriptional repression of platelet-derived growth factor receptor-beta by the zinc finger transcription factor ZNF24.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 24
    Names
    retinoic acid suppression protein A
    zinc finger and SCAN domain-containing protein 3
    zinc finger protein 191
    zinc finger protein 24 (KOX 17)
    zinc finger protein KOX17

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308123.2 → NP_001295052.1  zinc finger protein 24 isoform 2

      See identical proteins and their annotated locations for NP_001295052.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' and 3' structures compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC116447, AF542097, BG436261, CA314100
      Consensus CDS
      CCDS77175.1
      UniProtKB/Swiss-Prot
      P17028
      Related
      ENSP00000467655.1, ENST00000589881.5
      Conserved Domains (1) summary
      smart00431
      Location:48 → 160
      SCAN; leucine rich region

    2. NM_001375815.1 → NP_001362744.1  zinc finger protein 24 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC116447
      Consensus CDS
      CCDS11912.1
      UniProtKB/Swiss-Prot
      O14754, P17028, Q53YE4, Q6ICR5, Q8IZN4
      Related
      ENSP00000382015.2, ENST00000399061.3
      Conserved Domains (3) summary
      smart00431
      Location:48 → 160
      SCAN; leucine rich region
      COG5048
      Location:305 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_006965.4 → NP_008896.2  zinc finger protein 24 isoform 1

      See identical proteins and their annotated locations for NP_008896.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC116447
      Consensus CDS
      CCDS11912.1
      UniProtKB/Swiss-Prot
      O14754, P17028, Q53YE4, Q6ICR5, Q8IZN4
      Related
      ENSP00000261332.5, ENST00000261332.11
      Conserved Domains (3) summary
      smart00431
      Location:48 → 160
      SCAN; leucine rich region
      COG5048
      Location:305 → 358
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      35332227..35344420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      35523566..35535760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17028.4 GenPept UniProtKB/Swiss-Prot:P17028

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