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    PAK4 p21 (RAC1) activated kinase 4 [ Homo sapiens (human) ]

    Gene ID: 10298, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PAK4provided by HGNC
    Official Full Name
    p21 (RAC1) activated kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:16059
    See related
    Ensembl:ENSG00000130669 MIM:605451; AllianceGenome:HGNC:16059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 14.9), kidney (RPKM 12.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PAK4 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39125786..39182816)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (41929765..41986971)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39616426..39673456)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14611 Neighboring gene NANOG hESC enhancer GRCh37_chr19:39549145-39549646 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:39564087-39565286 Neighboring gene Sharpr-MPRA regulatory region 11111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39574861-39575361 Neighboring gene acid phosphatase 7, tartrate resistant (putative) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39622545-39623126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39623127-39623707 Neighboring gene uncharacterized LOC124904714 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39625781-39626526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39629677-39630266 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39634730-39635726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39635727-39636721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:39641079-39641580 Neighboring gene uncharacterized LOC124904716 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39647059-39647724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39648391-39649056 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:39649057-39649720 Neighboring gene NCCRP1, F-box associated domain containing Neighboring gene syncollin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. PAK4 kinase activity and somatic mutation promote carcinoma cell motility and influence inhibitor sensitivity. Whale AD, et al. Oncogene, 2013 Apr 18. PMID 22689056, Free PMC Article
    2. N-terminal interaction domain implicates PAK4 in translational regulation and reveals novel cellular localization signals. Baldassa S, et al. J Cell Physiol, 2010 Sep. PMID 20578242
    3. Why is PAK4 overexpressed in cancer? Costa TDF, et al. Int J Biochem Cell Biol, 2021 Sep. PMID 34274498
    4. cAMP Response Element Binding-Protein- and Phosphorylation-Dependent Regulation of Tyrosine Hydroxylase by PAK4: Implications for Dopamine Replacement Therapy. Won SY, et al. Mol Cells, 2021 Jul 31. PMID 34238765, Free PMC Article
    5. Activated-PAK4 predicts worse prognosis in breast cancer and promotes tumorigenesis through activation of PI3K/AKT signaling. He LF, et al. Oncotarget, 2017 Mar 14. PMID 28407679, Free PMC Article

    See all (213) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PAK4 Is Involved in the Stabilization of PD-L1 and the Resistance to Doxorubicin in Osteosarcoma and Predicts the Survival of Diagnosed Patients.
      Title: PAK4 Is Involved in the Stabilization of PD-L1 and the Resistance to Doxorubicin in Osteosarcoma and Predicts the Survival of Diagnosed Patients.
    2. Tumorigenic role of Pak4 in ovarian cancer and its correlation with immune infiltration.
      Title: Tumorigenic role of Pak4 in ovarian cancer and its correlation with immune infiltration.
    3. TBC1D10B promotes tumor progression in colon cancer via PAK4-mediated promotion of the PI3K/AKT/mTOR pathway.
      Title: TBC1D10B promotes tumor progression in colon cancer via PAK4‑mediated promotion of the PI3K/AKT/mTOR pathway.
    4. PAK4 phosphorylates and inhibits AMPKalpha to control glucose uptake.
      Title: PAK4 phosphorylates and inhibits AMPKα to control glucose uptake.
    5. The role of p21-activated kinase 4 in the progression of oral squamous cell carcinoma by targeting PI3K-AKT signaling pathway.
      Title: The role of p21-activated kinase 4 in the progression of oral squamous cell carcinoma by targeting PI3K-AKT signaling pathway.
    6. Pan-cancer analysis identifies the immunological and prognostic role of PAK4.
      Title: Pan-cancer analysis identifies the immunological and prognostic role of PAK4.
    7. PAK4 expression is associated with the prognosis in non-small cell lung cancer.
      Title: PAK4 expression is associated with the prognosis in non-small cell lung cancer.
    8. PAK4 in cancer development: Emerging player and therapeutic opportunities.
      Title: PAK4 in cancer development: Emerging player and therapeutic opportunities.
    9. Targeting of p21-Activated Kinase 4 Radiosensitizes Glioblastoma Cells via Impaired DNA Repair.
      Title: Targeting of p21-Activated Kinase 4 Radiosensitizes Glioblastoma Cells via Impaired DNA Repair.
    10. miR-425 regulates ovarian cancer proliferation, metastasis, and apoptosis by repressing PAK4 expression.
      Title: miR-425 regulates ovarian cancer proliferation, metastasis, and apoptosis by repressing PAK4 expression.
    Submit: New GeneRIF Correction See all GeneRIFs (122)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of p21 protein (Cdc42/Rac)-activated kinase 4 (PAK4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cadherin binding involved in cell-cell adhesion HDA PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in dendritic spine development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of endothelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell growth TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in adherens junction HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in focal adhesion HDA PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 4
    Names
    p21 protein (Cdc42/Rac)-activated kinase 4
    p21(CDKN1A)-activated kinase 4
    protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
    NP_001014831.1
    NP_001014832.1
    NP_001014834.1
    NP_001014835.1
    NP_001381430.1
    NP_005875.1
    XP_011524618.1
    XP_011524619.1
    XP_011524622.1
    XP_024307082.1
    XP_047293990.1
    XP_047293991.1
    XP_047293992.1
    XP_047293993.1
    XP_047293994.1
    XP_047293996.1
    XP_047293997.1
    XP_054175478.1
    XP_054175479.1
    XP_054175480.1
    XP_054175481.1
    XP_054175482.1
    XP_054175483.1
    XP_054175484.1
    XP_054175485.1
    XP_054175486.1
    XP_054175487.1
    XP_054175488.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047118.2 RefSeqGene

      Range
      5002..58620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014831.3 → NP_001014831.1  serine/threonine-protein kinase PAK 4 isoform 1

      See identical proteins and their annotated locations for NP_001014831.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 5' UTR, and encodes the same isoform (1), as compared to variant 1.
      Source sequence(s)
      AB032968, AC011443, BC025282, BG773480
      Consensus CDS
      CCDS12528.1
      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8
      UniProtKB/TrEMBL
      A8K724
      Related
      ENSP00000469413.1, ENST00000593690.5
      Conserved Domains (2) summary
      cd06657
      Location:300 → 591
      STKc_PAK4; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    2. NM_001014832.2 → NP_001014832.1  serine/threonine-protein kinase PAK 4 isoform 1

      See identical proteins and their annotated locations for NP_001014832.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' UTR, and encodes the same isoform (1), as compared to variant 1.
      Source sequence(s)
      AB032968, AC011443, BC011368, BC025282, BG773480
      Consensus CDS
      CCDS12528.1
      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8
      UniProtKB/TrEMBL
      A8K724
      Related
      ENSP00000351049.2, ENST00000358301.7
      Conserved Domains (2) summary
      cd06657
      Location:300 → 591
      STKc_PAK4; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    3. NM_001014834.3 → NP_001014834.1  serine/threonine-protein kinase PAK 4 isoform 2

      See identical proteins and their annotated locations for NP_001014834.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an exon in the 5' UTR and an in-frame exon in the coding region, as compared to variant 1. The encoded isoform (2) thus lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AB032968, AC011443, AL834236, BG773480
      Consensus CDS
      CCDS33019.1
      UniProtKB/TrEMBL
      B4DE88
      Related
      ENSP00000470284.1, ENST00000599470.5
      Conserved Domains (2) summary
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:147 → 438
      PKc_like; Protein Kinases, catalytic domain

    4. NM_001014835.2 → NP_001014835.1  serine/threonine-protein kinase PAK 4 isoform 2

      See identical proteins and their annotated locations for NP_001014835.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, as compared to variant 1. The encoded isoform (2) thus lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AB032968, AC011443, BG773480
      Consensus CDS
      CCDS33019.1
      UniProtKB/TrEMBL
      B4DE88
      Related
      ENSP00000471157.1, ENST00000599386.5
      Conserved Domains (2) summary
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:147 → 438
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001394501.1 → NP_001381430.1  serine/threonine-protein kinase PAK 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC011443
      Consensus CDS
      CCDS12528.1
      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8
      UniProtKB/TrEMBL
      A8K724
      Conserved Domains (2) summary
      cd06657
      Location:300 → 591
      STKc_PAK4; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    6. NM_005884.5 → NP_005875.1  serine/threonine-protein kinase PAK 4 isoform 1

      See identical proteins and their annotated locations for NP_005875.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB032968, AF005046, BG773480
      Consensus CDS
      CCDS12528.1
      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8
      UniProtKB/TrEMBL
      A8K724
      Related
      ENSP00000353625.3, ENST00000360442.8
      Conserved Domains (2) summary
      cd06657
      Location:300 → 591
      STKc_PAK4; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39125786..39182816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526316.2 → XP_011524618.1  serine/threonine-protein kinase PAK 4 isoform X1

      See identical proteins and their annotated locations for XP_011524618.1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8
      UniProtKB/TrEMBL
      A8K724
      Conserved Domains (2) summary
      cd06657
      Location:300 → 591
      STKc_PAK4; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    2. XM_011526320.2 → XP_011524622.1  serine/threonine-protein kinase PAK 4 isoform X2

      See identical proteins and their annotated locations for XP_011524622.1

      UniProtKB/TrEMBL
      B4DE88
      Conserved Domains (2) summary
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:147 → 438
      PKc_like; Protein Kinases, catalytic domain

    3. XM_047438034.1 → XP_047293990.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8

    4. XM_024451314.2 → XP_024307082.1  serine/threonine-protein kinase PAK 4 isoform X2

      UniProtKB/TrEMBL
      B4DE88
      Conserved Domains (2) summary
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:147 → 438
      PKc_like; Protein Kinases, catalytic domain

    5. XM_011526317.3 → XP_011524619.1  serine/threonine-protein kinase PAK 4 isoform X1

      See identical proteins and their annotated locations for XP_011524619.1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8
      UniProtKB/TrEMBL
      A8K724
      Conserved Domains (2) summary
      cd06657
      Location:300 → 591
      STKc_PAK4; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4
      cd01093
      Location:10 → 55
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    6. XM_047438040.1 → XP_047293996.1  serine/threonine-protein kinase PAK 4 isoform X2

    7. XM_047438037.1 → XP_047293993.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8

    8. XM_047438038.1 → XP_047293994.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8

    9. XM_047438036.1 → XP_047293992.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8

    10. XM_047438035.1 → XP_047293991.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8

    11. XM_047438041.1 → XP_047293997.1  serine/threonine-protein kinase PAK 4 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      41929765..41986971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319503.1 → XP_054175478.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8

    2. XM_054319510.1 → XP_054175485.1  serine/threonine-protein kinase PAK 4 isoform X2

    3. XM_054319504.1 → XP_054175479.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8

    4. XM_054319505.1 → XP_054175480.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8

    5. XM_054319512.1 → XP_054175487.1  serine/threonine-protein kinase PAK 4 isoform X2

    6. XM_054319511.1 → XP_054175486.1  serine/threonine-protein kinase PAK 4 isoform X2

    7. XM_054319508.1 → XP_054175483.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8

    8. XM_054319509.1 → XP_054175484.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8

    9. XM_054319507.1 → XP_054175482.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8

    10. XM_054319506.1 → XP_054175481.1  serine/threonine-protein kinase PAK 4 isoform X1

      UniProtKB/Swiss-Prot
      B4DGG6, O96013, Q8N4E1, Q8NCH5, Q8NDE3, Q9BU33, Q9ULS8

    11. XM_054319513.1 → XP_054175488.1  serine/threonine-protein kinase PAK 4 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001014833.1: Suppressed sequence

      Description
      NM_001014833.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O96013.1 GenPept UniProtKB/Swiss-Prot:O96013

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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