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    LRRC3 leucine rich repeat containing 3 [ Homo sapiens (human) ]

    Gene ID: 81543, updated on 27-Nov-2024

    Summary

    Official Symbol
    LRRC3provided by HGNC
    Official Full Name
    leucine rich repeat containing 3provided by HGNC
    Primary source
    HGNC:HGNC:14965
    See related
    Ensembl:ENSG00000160233 MIM:617620; AllianceGenome:HGNC:14965
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRRC3DN; C21orf30; C21orf102
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver (RPKM 2.2), ovary (RPKM 1.8) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LRRC3 in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44455510..44462196)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42815963..42822649)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45875393..45882079)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel subfamily M member 2 Neighboring gene Z6 small nucleolar RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45861695-45862234 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45874390-45874890 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45875054-45875233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13384 Neighboring gene LRRC3 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45879794-45880676 Neighboring gene MT-CYB pseudogene 21 Neighboring gene MT-ND6 pseudogene 21 Neighboring gene MT-ND5 pseudogene 1 Neighboring gene hepatocellular carcinoma ferroptosis associative lncRNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp434C128

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 3
    Names
    LRRC3 downstream neighbor (non-protein coding)
    intronless long ORF, AL117578

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030891.6NP_112153.1  leucine-rich repeat-containing protein 3 precursor

      See identical proteins and their annotated locations for NP_112153.1

      Status: VALIDATED

      Source sequence(s)
      AK127604, AL117578, AP001065, BC064321
      Consensus CDS
      CCDS13711.1
      UniProtKB/Swiss-Prot
      Q0VDJ2, Q9BY71
      Related
      ENSP00000291592.4, ENST00000291592.6
      Conserved Domains (4) summary
      smart00013
      Location:3268
      LRRNT; Leucine rich repeat N-terminal domain
      sd00031
      Location:4865
      LRR_1; leucine-rich repeat [structural motif]
      pfam12799
      Location:89129
      LRR_4; Leucine Rich repeats (2 copies)
      pfam13855
      Location:69125
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      44455510..44462196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      42815963..42822649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)