TEX101 testis expressed 101 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TEX101provided by HGNC
Official Full Name: testis expressed 101provided by HGNC
Primary source: HGNC:HGNC:30722
See related: Ensembl:ENSG00000131126 MIM:612665; AllianceGenome:HGNC:30722
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SGRG; CT131; GTPR867; NYD-SP8; PRO1884; SPATA44; TES101RP
Summary: Predicted to be involved in binding activity of sperm to zona pellucida; flagellated sperm motility; and regulation of flagellated sperm motility. Predicted to be located in acrosomal vesicle; extracellular region; and plasma membrane. Predicted to be active in plasma membrane raft. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis (RPKM 41.7) See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.31

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (43388611..43418597)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (46209044..46238972)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (43892763..43922749)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains.
Title: Crystal structure of TEX101, a glycoprotein essential for male fertility, reveals the presence of tandemly arranged Ly6/uPAR domains.
Role of the Glycosylphosphatidylinositol-Anchored Protein TEX101 and Its Related Molecules in Spermatogenesis.
Title: Role of the Glycosylphosphatidylinositol-Anchored Protein TEX101 and Its Related Molecules in Spermatogenesis.
Study provides evidence that spermatozoa of rs35033974 homozygous men have substantially reduced levels of TEX101 and could be used as a model to elucidate the precise TEX101 function. Because TEX101 seminal plasma levels were found significantly lower in heterozygous than in WT men, rs35033974 status could be considered in TEX101 diagnostics.
Title: Identification of TEX101-associated Proteins Through Proteomic Measurement of Human Spermatozoa Homozygous for the Missense Variant rs35033974.
Overexpression of TEX101 is associated with breast tumors.
Title: Transcriptome analysis of the cancer/testis genes, DAZ1, AURKC, and TEX101, in breast tumors and six breast cancer cell lines.
Clinical assays for ECM1 and TEX101 have the potential to replace most of the diagnostic testicular biopsies and facilitate the prediction of outcome of sperm retrieval procedures, increasing the reliability and success of assisted reproduction techniques
Title: Differential diagnosis of azoospermia with proteomic biomarkers ECM1 and TEX101 quantified in seminal plasma.
TEX101 is a cancer-testis (CT) gene useful for detection of CML. It was expressed in 30% of CML patients, but not in healthy donors. Unlike many CT genes, overexpression of TEX101 was not shown to induce immunologic responses in these samples.
Title: Expression of testis-specific genes, TEX101 and ODF4, in chronic myeloid leukemia and evaluation of TEX101 immunogenicity.
Combination of two proteins, SPAG11B and TEX101, can be used for differential diagnosis of azoospermia
Title: Verification of male infertility biomarkers in seminal plasma by multiplex selected reaction monitoring assay.
Overexpression of NYD-SP8 in various nasopharyngeal carcinoma cell lines indicated its complicated functions, and that it could play an important role in nasopharyngeal carcinoma carcinogenesis.
Title: Preparation of anti-NYD-SP8 rabbit polyclonal antibody and its application in the analysis of NYD-SP8 expression in nasopharyngeal carcinoma cell lines and clinical tissues.
NYD-SP8 has a role in regulating ECM degradation, providing a novel mechanism that modulates urokinase signalling in the suppression of cancer progression
Title: A suppressor of multiple extracellular matrix-degrading proteases and cancer metastasis.
The SPATA19 and TEX101 genes may be possible targets for cancer immunotherapy and novel markers for early detection of basal cell carcinoma.
Title: Elevated expression levels of testis-specific genes TEX101 and SPATA19 in basal cell carcinoma and their correlation with clinical and pathological features.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
The Contribution of Common Genetic Variation to Nicotine and Cotinine Glucuronidation in Multiple Ethnic/Racial Populations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3S2771E (e-PCR)
- UniSTS:150811

RH92107 (e-PCR)
- UniSTS:90674

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in binding of sperm to zona pellucida	ISS Inferred from Sequence or Structural Similarity more info
involved_in fertilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of flagellated sperm motility	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in acrosomal membrane	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in plasma membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: testis-expressed protein 101

Names: TES101-reactive protein; cancer/testis antigen 131; cell surface receptor NYD-SP8; scleroderma-associated autoantigen; spermatogenesis associated 44; spermatogenesis-related gene protein; testis expressed sequence 101; testis-expressed sequence 101 protein; testis-specific protein TES101RP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130011.3 → NP_001123483.1 testis-expressed protein 101 isoform 2 precursor

See identical proteins and their annotated locations for NP_001123483.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences in the 5' end and uses a downstream translation start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when compared to isoform 1.

Source sequence(s)

AC018758, AY359077

Consensus CDS

CCDS59393.1

UniProtKB/Swiss-Prot

Q7L5R2, Q9BPY7, Q9BY14

Related

ENSP00000472769.1, ENST00000598265.2

Conserved Domains (1) summary

cl10471
Location:140 → 209

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
NM_031451.5 → NP_113639.4 testis-expressed protein 101 isoform 1

See identical proteins and their annotated locations for NP_113639.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).

Source sequence(s)

AA417291, AF241268, BC001861

Consensus CDS

CCDS12619.1

Related

ENSP00000472308.1, ENST00000602198.5

Conserved Domains (1) summary

cl10471
Location:158 → 227

LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...