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    ZFP91 ZFP91 zinc finger protein, atypical E3 ubiquitin ligase [ Homo sapiens (human) ]

    Gene ID: 80829, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZFP91provided by HGNC
    Official Full Name
    ZFP91 zinc finger protein, atypical E3 ubiquitin ligaseprovided by HGNC
    Primary source
    HGNC:HGNC:14983
    See related
    Ensembl:ENSG00000186660 MIM:619289; AllianceGenome:HGNC:14983
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PZF; DSM8; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757
    Summary
    The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]
    Expression
    Broad expression in testis (RPKM 63.1), bone marrow (RPKM 24.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZFP91 in Genome Data Viewer
    Location:
    11q12.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (58579063..58621550)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (58528573..58571048)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (58346536..58389023)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369313 Neighboring gene Sharpr-MPRA regulatory region 15251 Neighboring gene olfactory receptor family 5 subfamily B member 21 Neighboring gene leupaxin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4735 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4737 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:58345528-58346220 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:58346914-58347605 Neighboring gene ZFP91-CNTF readthrough (NMD candidate) Neighboring gene ciliary neurotrophic factor Neighboring gene NANOG hESC enhancer GRCh37_chr11:58419172-58419673 Neighboring gene NANOG hESC enhancer GRCh37_chr11:58420305-58420859 Neighboring gene glycine-N-acyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Zinc finger protein 91 accelerates tumour progression by activating β-catenin signalling in pancreatic cancer. Tang N, et al. Cell Prolif, 2021 May. PMID 33755268, Free PMC Article
    2. ZFP91-a newly described gene potentially involved in prostate pathology. Paschke L, et al. Pathol Oncol Res, 2014 Apr. PMID 24272675, Free PMC Article
    3. ZFP91: A Noncanonical NF-κB Signaling Pathway Regulator with Oncogenic Properties Is Overexpressed in Prostate Cancer. Paschke L, et al. Biomed Res Int, 2016. PMID 27975057, Free PMC Article
    4. A retroviral vector common integration site between leupaxin and zinc finger protein 91 (ZFP91) observed in baboon hematopoietic repopulating cells. Kiem HP, et al. Exp Hematol, 2010 Sep. PMID 20434516, Free PMC Article
    5. Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy. Liu TT, et al. EBioMedicine, 2022 Dec. PMID 36375317, Free PMC Article

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy.
      Title: Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy.
    2. Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
      Title: Zinc finger protein 91 mediates necroptosis by initiating RIPK1-RIPK3-MLKL signal transduction in response to TNF receptor 1 ligation.
    3. Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1.
      Title: Overcoming IMiD resistance in T-cell lymphomas through potent degradation of ZFP91 and IKZF1.
    4. ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.
      Title: ZFP91 disturbs metabolic fitness and antitumor activity of tumor-infiltrating T cells.
    5. MicroRNA1885p inhibits the progression of breast cancer by targeting zinc finger protein 91.
      Title: MicroRNA‑188‑5p inhibits the progression of breast cancer by targeting zinc finger protein 91.
    6. E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing.
      Title: E3 ligase ZFP91 inhibits Hepatocellular Carcinoma Metabolism Reprogramming by regulating PKM splicing.
    7. Zinc finger protein 91 accelerates tumour progression by activating beta-catenin signalling in pancreatic cancer.
      Title: Zinc finger protein 91 accelerates tumour progression by activating β-catenin signalling in pancreatic cancer.
    8. Roles of miR-640 and Zinc Finger Protein 91 (ZFP91) in Angiopoietin-1-Induced In Vitro Angiogenesis.
      Title: Roles of miR-640 and Zinc Finger Protein 91 (ZFP91) in Angiopoietin-1-Induced In Vitro Angiogenesis.
    9. The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization.
      Title: The ubiquitinase ZFP91 promotes tumor cell survival and confers chemoresistance through FOXA1 destabilization.
    10. research describes a mechanism by which ZFP91 promotes production of IL-1beta under physiological conditions and suggests that ZFP91 may be a promising therapeutic target for intervention in inflammatory, infectious and autoimmune-related diseases
      Title: Zinc finger protein 91 positively regulates the production of IL-1β in macrophages by activation of MAPKs and non-canonical caspase-8 inflammasome.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat is identified to have a physical interaction with zinc finger protein 91 homolog (ZFP91) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ57065

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of NF-kappaB-inducing kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ZFP91
    Names
    RING-type E3 ubiquitin transferase ZFP91
    drug resistance-associated sequence in melanoma 8
    penta zinc finger protein
    zinc finger protein 757
    zinc finger protein 91 homolog
    zinc finger protein homologous to Zfp91 in mouse
    NP_001183980.1
    NP_444251.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001197051.2 → NP_001183980.1  E3 ubiquitin-protein ligase ZFP91 isoform 2

      See identical proteins and their annotated locations for NP_001183980.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      AB056107, AI687439, AP001350, BC051743, BP219969
      Conserved Domains (2) summary
      sd00017
      Location:346 → 365
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:400 → 421
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_053023.5 → NP_444251.1  E3 ubiquitin-protein ligase ZFP91 isoform 1

      See identical proteins and their annotated locations for NP_444251.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AB056107, AI687439, AP001350, BC051743, BP219969
      Consensus CDS
      CCDS31553.1
      UniProtKB/Swiss-Prot
      A6NHC4, A8MSG7, Q86V47, Q96JP4, Q96JP5, Q96QA3
      Related
      ENSP00000339030.5, ENST00000316059.7
      Conserved Domains (2) summary
      sd00017
      Location:347 → 366
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:401 → 422
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      58579063..58621550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      58528573..58571048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96JP5.1 GenPept UniProtKB/Swiss-Prot:Q96JP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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