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    EXOC6 exocyst complex component 6 [ Homo sapiens (human) ]

    Gene ID: 54536, updated on 2-Nov-2024

    Summary

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    Official Symbol
    EXOC6provided by HGNC
    Official Full Name
    exocyst complex component 6provided by HGNC
    Primary source
    HGNC:HGNC:23196
    See related
    Ensembl:ENSG00000138190 MIM:609672; AllianceGenome:HGNC:23196
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SEC15; EXOC6A; SEC15L; Sec15p; SEC15L1; SEC15L3
    Summary
    The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in thyroid (RPKM 11.4), placenta (RPKM 9.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EXOC6 in Genome Data Viewer
    Location:
    10q23.33
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (92826831..93059490)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (93706495..93939384)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (94586588..94819247)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2622 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2623 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:94451023-94451830 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 3 Neighboring gene NUP98-HHEX recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3776 Neighboring gene NANOG hESC enhancer GRCh37_chr10:94480033-94480588 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94487019-94487521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3777 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2624 Neighboring gene hematopoietically expressed homeobox Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3778 Neighboring gene VISTA enhancer hs1866 Neighboring gene Sharpr-MPRA regulatory region 4238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2626 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:94652149-94652648 Neighboring gene NANOG hESC enhancer GRCh37_chr10:94653981-94654616 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:94667799-94667959 Neighboring gene Sharpr-MPRA regulatory region 15544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3780 Neighboring gene Sharpr-MPRA regulatory region 5548 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:94820573-94821482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3782 Neighboring gene cytochrome P450 family 26 subfamily C member 1 Neighboring gene cytochrome P450 family 26 subfamily A member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Exocyst proteins in cytokinesis: Regulation by Rab11. Neto H, et al. Commun Integr Biol, 2013 Nov 1. PMID 24563720, Free PMC Article
    2. Exocyst complex protein expression in the human placenta. Gonzalez IM, et al. Placenta, 2014 Jul. PMID 24856041, Free PMC Article
    3. Sec15 is an effector for the Rab11 GTPase in mammalian cells. Zhang XM, et al. J Biol Chem, 2004 Oct 8. PMID 15292201
    4. Architectures of multisubunit complexes revealed by a visible immunoprecipitation assay using fluorescent fusion proteins. Katoh Y, et al. J Cell Sci, 2015 Jun 15. PMID 25964651
    5. Rab11 regulates exocytosis of recycling vesicles at the plasma membrane. Takahashi S, et al. J Cell Sci, 2012 Sep 1. PMID 22685325

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by triggering the switch in binding specificity of Rabin8 from PS to Sec15.
      Title: NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15.
    2. coordinated disruption of the Rab11/Sec15 exocyst by anthrax toxins may contribute to toxin-dependent barrier disruption and vascular dysfunction during B. anthracis infection
      Title: Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: An integrative method for scoring candidate genes from association studies: application to warfarin dosing.
    5. Sec15 has a role as an effector for the Rab11 GTPase in mammalian cells
      Title: Sec15 is an effector for the Rab11 GTPase in mammalian cells.
    6. The SEC15 protein plays a crucial role in integrating the signals between Sec4p and the components of the early-polarity-establishment machinery.
      Title: The polarity-establishment component Bem1p interacts with the exocyst complex through the Sec15p subunit.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that exocyst complex component 6 (EXOC6) is a Nef-binding protein in Jurkat cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ1125, FLJ11251, MGC33397, DKFZp761I2124

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane fission NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cytokinesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle docking involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in vesicle tethering involved in exocytosis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    exocyst complex component 6
    Names
    SEC15-like 1
    SEC15-like protein 3
    exocyst complex component Sec15A
    rsec15-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013848.4 → NP_001013870.1  exocyst complex component 6 isoform b

      See identical proteins and their annotated locations for NP_001013870.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 3. The encoded isoform (b) is shorter at the N-terminus, compared to isoform c.
      Source sequence(s)
      AL157705, AL358613, AL392103, AL590080
      Consensus CDS
      CCDS31247.1
      UniProtKB/TrEMBL
      B3KXY5
      Related
      ENSP00000500529.1, ENST00000671701.1
      Conserved Domains (1) summary
      pfam04091
      Location:451 → 757
      Sec15; Exocyst complex subunit Sec15-like

    2. NM_001319194.2 → NP_001306123.1  exocyst complex component 6 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AL157705, AL358613, AL392103, AL590080
      UniProtKB/TrEMBL
      B7Z6G5
      Conserved Domains (1) summary
      pfam04091
      Location:472 → 778
      Sec15; Exocyst complex subunit Sec15-like

    3. NM_001319195.2 → NP_001306124.1  exocyst complex component 6 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two 5' exons but instead contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, and it also uses an alternate in-frame splice site in the central coding region, compared to variant 3. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform c.
      Source sequence(s)
      AL157705, AL358613, AL392103, AL590080
      UniProtKB/TrEMBL
      B4DEZ1
      Conserved Domains (1) summary
      pfam04091
      Location:456 → 761
      Sec15; Exocyst complex subunit Sec15-like

    4. NM_001319200.2 → NP_001306129.1  exocyst complex component 6 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two 5' exons but instead contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, and it also lacks four internal exons resulting in the loss of two in-frame segments in the central coding region, compared to variant 3. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform c.
      Source sequence(s)
      AL157705, AL358613, AL392103, AL590080
      Consensus CDS
      CCDS81487.1
      UniProtKB/TrEMBL
      A5YP36, E7EW84
      Related
      ENSP00000396206.2, ENST00000443748.6
      Conserved Domains (1) summary
      pfam04091
      Location:353 → 659
      Sec15; Exocyst complex subunit Sec15-like

    5. NM_019053.6 → NP_061926.3  exocyst complex component 6 isoform a

      See identical proteins and their annotated locations for NP_061926.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks two 5' exons but instead contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 3. The encoded isoform (a) has a distinct and shorter N-terminus, compared to isoform c.
      Source sequence(s)
      AL157705, AL358613, AL392103, AL590080
      Consensus CDS
      CCDS7424.2
      UniProtKB/Swiss-Prot
      E9PHI3, Q5VXH8, Q8TAG9, Q9NZ24
      UniProtKB/TrEMBL
      B4DEZ1
      Related
      ENSP00000260762.6, ENST00000260762.10
      Conserved Domains (1) summary
      pfam04091
      Location:456 → 762
      Sec15; Exocyst complex subunit Sec15-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      92826831..93059490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016344.3 → XP_016871833.1  exocyst complex component 6 isoform X1

      UniProtKB/TrEMBL
      B7Z6G5

    2. XM_047425369.1 → XP_047281325.1  exocyst complex component 6 isoform X7

    3. XM_017016348.2 → XP_016871837.1  exocyst complex component 6 isoform X6

      UniProtKB/TrEMBL
      B7Z6G5

    4. XM_017016345.3 → XP_016871834.1  exocyst complex component 6 isoform X2

      UniProtKB/TrEMBL
      B3KXY5
      Related
      ENSP00000360607.4, ENST00000371552.8
      Conserved Domains (1) summary
      pfam04091
      Location:451 → 757
      Sec15; Exocyst complex subunit Sec15-like

    5. XM_017016346.3 → XP_016871835.1  exocyst complex component 6 isoform X3

      UniProtKB/TrEMBL
      B3KXY5

    6. XM_024448047.2 → XP_024303815.1  exocyst complex component 6 isoform X5

      UniProtKB/TrEMBL
      B2RDH5
      Conserved Domains (1) summary
      pfam04091
      Location:409 → 715
      Sec15; Exocyst complex subunit Sec15-like

    7. XM_017016347.3 → XP_016871836.1  exocyst complex component 6 isoform X4

      UniProtKB/TrEMBL
      B2RDH5
      Conserved Domains (1) summary
      pfam04091
      Location:435 → 741
      Sec15; Exocyst complex subunit Sec15-like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      93706495..93939384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366129.1 → XP_054222104.1  exocyst complex component 6 isoform X1

    2. XM_054366133.1 → XP_054222108.1  exocyst complex component 6 isoform X7

    3. XM_054366132.1 → XP_054222107.1  exocyst complex component 6 isoform X6

    4. XM_054366131.1 → XP_054222106.1  exocyst complex component 6 isoform X5

    5. XM_054366130.1 → XP_054222105.1  exocyst complex component 6 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TAG9.3 GenPept UniProtKB/Swiss-Prot:Q8TAG9

    Gene LinkOut

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