USP32 ubiquitin specific peptidase 32 [Homo sapiens (human)] - Gene

Summary

Official Symbol: USP32provided by HGNC
Official Full Name: ubiquitin specific peptidase 32provided by HGNC
Primary source: HGNC:HGNC:19143
See related: Ensembl:ENSG00000170832 MIM:607740; AllianceGenome:HGNC:19143
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: USP10; NY-REN-60
Summary: Enables cysteine-type deubiquitinase activity. Involved in positive regulation of TORC1 signaling. Located in cytosol. Is active in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis (RPKM 36.8), brain (RPKM 14.5) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q23.1-q23.2

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (60177327..60422416, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (61046275..61291441, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (58254688..58469494, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Furin Egress from the TGN is Regulated by Membrane-Associated RING-CH Finger (MARCHF) Proteins and Ubiquitin-Specific Protease 32 (USP32) via Nondegradable K33-Polyubiquitination.
Title: Furin Egress from the TGN is Regulated by Membrane-Associated RING-CH Finger (MARCHF) Proteins and Ubiquitin-Specific Protease 32 (USP32) via Nondegradable K33-Polyubiquitination.
High USP32 expression contributes to cancer progression and is correlated with immune infiltrates in hepatocellular carcinoma.
Title: High USP32 expression contributes to cancer progression and is correlated with immune infiltrates in hepatocellular carcinoma.
Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells.
Title: Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells.
Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours.
Title: Deubiquitylation of Rab35 by USP32 promotes the transmission of imatinib resistance by enhancing exosome secretion in gastrointestinal stromal tumours.
Identification of ubiquitin-specific protease 32 as an oncogene in glioblastoma and the underlying mechanisms.
Title: Identification of ubiquitin-specific protease 32 as an oncogene in glioblastoma and the underlying mechanisms.
USP32 confers cancer cell resistance to YM155 via promoting ER-associated degradation of solute carrier protein SLC35F2.
Title: USP32 confers cancer cell resistance to YM155 via promoting ER-associated degradation of solute carrier protein SLC35F2.
USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2.
Title: USP32 promotes tumorigenesis and chemoresistance in gastric carcinoma via upregulation of SMAD2.
Ubiquitin specific peptidase 32 acts as an oncogene in epithelial ovarian cancer by deubiquitylating farnesyl-diphosphate farnesyltransferase 1.
Title: Ubiquitin specific peptidase 32 acts as an oncogene in epithelial ovarian cancer by deubiquitylating farnesyl-diphosphate farnesyltransferase 1.
the small GTPase Rab7-the logistical centerpiece of late endosome biology-is a substrate of USP32.
Title: USP32 regulates late endosomal transport and recycling through deubiquitylation of Rab7.
USP32 silencing arrested cell cycle progression at G0/G1 phase via decreasing CDK4/Cyclin D1 complex and elevating p21.
Title: Downregulation of USP32 inhibits cell proliferation, migration and invasion in human small cell lung cancer.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S923 (e-PCR), detects polymorphism
- UniSTS:75015

D17S923 (e-PCR), detects polymorphism
- UniSTS:8974

D1S1350 (e-PCR)
- UniSTS:149546

RH44395 (e-PCR)
- UniSTS:64578

STS-N68447 (e-PCR)
- UniSTS:27535

SHGC-132932 (e-PCR)
- UniSTS:170944

SHGC-57390 (e-PCR)
- UniSTS:59339

SHGC-58603 (e-PCR)
- UniSTS:94419

AFMa274wh5 (e-PCR)
- UniSTS:49632

D17S2128 (e-PCR)
- UniSTS:64493

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein deubiquitination	TAS Traceable Author Statement more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 32

Names: deubiquitinating enzyme 32; renal carcinoma antigen NY-REN-60; ubiquitin specific protease 32; ubiquitin thioesterase 32; ubiquitin thiolesterase 32; ubiquitin-specific-processing protease 32

NP_115971.2

EC 3.4.19.12

XP_011523673.1

EC 3.4.19.12

XP_011523674.1

EC 3.4.19.12

XP_011523675.1

EC 3.4.19.12

XP_011523676.1

EC 3.4.19.12

XP_011523677.1

EC 3.4.19.12

XP_011523678.1

EC 3.4.19.12

XP_011523680.1

EC 3.4.19.12

XP_011523681.1

EC 3.4.19.12

XP_016880722.1

EC 3.4.19.12

XP_047292899.1

EC 3.4.19.12

XP_047292900.1

EC 3.4.19.12

XP_047292901.1

EC 3.4.19.12

XP_054173541.1

EC 3.4.19.12

XP_054173542.1

EC 3.4.19.12

XP_054173543.1

EC 3.4.19.12

XP_054173544.1

EC 3.4.19.12

XP_054173545.1

EC 3.4.19.12

XP_054173546.1

EC 3.4.19.12

XP_054173547.1

EC 3.4.19.12

XP_054173548.1

EC 3.4.19.12

XP_054173549.1

EC 3.4.19.12

XP_054173550.1

EC 3.4.19.12

XP_054173551.1

EC 3.4.19.12

XP_054173552.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032582.4 → NP_115971.2 ubiquitin carboxyl-terminal hydrolase 32

See identical proteins and their annotated locations for NP_115971.2

Status: VALIDATED

Source sequence(s)

AC025048, AF533230, AL834444, BI459907

Consensus CDS

CCDS32697.1

UniProtKB/Swiss-Prot

Q7Z5T3, Q8NFA0, Q9BX85, Q9Y591

Related

ENSP00000300896.3, ENST00000300896.9

Conserved Domains (6) summary

COG5560
Location:518 → 1316

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd00051
Location:237 → 293

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl02553
Location:1225 → 1565

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam06337
Location:519 → 586

DUSP; DUSP domain

pfam13499
Location:236 → 293

EF-hand_7; EF-hand domain pair

pfam14836
Location:623 → 710

Ubiquitin_3; Ubiquitin-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

60177327..60422416 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011525372.2 → XP_011523674.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X2

Conserved Domains (6) summary

COG5560
Location:534 → 1332

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd00051
Location:253 → 309

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl02553
Location:1241 → 1581

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam06337
Location:535 → 602

DUSP; DUSP domain

pfam13499
Location:252 → 309

EF-hand_7; EF-hand domain pair

pfam14836
Location:639 → 726

Ubiquitin_3; Ubiquitin-like domain
XM_011525371.2 → XP_011523673.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X1

Conserved Domains (6) summary

COG5560
Location:534 → 1346

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd00051
Location:253 → 309

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl02553
Location:1255 → 1595

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam06337
Location:535 → 602

DUSP; DUSP domain

pfam13499
Location:252 → 309

EF-hand_7; EF-hand domain pair

pfam14836
Location:653 → 740

Ubiquitin_3; Ubiquitin-like domain
XM_011525376.2 → XP_011523678.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X6

Conserved Domains (6) summary

COG5560
Location:515 → 1313

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd00051
Location:234 → 290

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl02553
Location:1222 → 1562

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam06337
Location:516 → 583

DUSP; DUSP domain

pfam13499
Location:233 → 290

EF-hand_7; EF-hand domain pair

pfam14836
Location:620 → 707

Ubiquitin_3; Ubiquitin-like domain
XM_011525374.2 → XP_011523676.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X4

Conserved Domains (6) summary

COG5560
Location:515 → 1327

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd00051
Location:234 → 290

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl02553
Location:1236 → 1576

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam06337
Location:516 → 583

DUSP; DUSP domain

pfam13499
Location:233 → 290

EF-hand_7; EF-hand domain pair

pfam14836
Location:634 → 721

Ubiquitin_3; Ubiquitin-like domain
XM_011525373.2 → XP_011523675.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X3

Conserved Domains (6) summary

COG5560
Location:518 → 1330

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd00051
Location:237 → 293

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl02553
Location:1239 → 1579

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam06337
Location:519 → 586

DUSP; DUSP domain

pfam13499
Location:236 → 293

EF-hand_7; EF-hand domain pair

pfam14836
Location:637 → 724

Ubiquitin_3; Ubiquitin-like domain
XM_011525375.2 → XP_011523677.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X5

Conserved Domains (6) summary

COG5560
Location:508 → 1320

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd00051
Location:227 → 283

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl02553
Location:1229 → 1569

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam06337
Location:509 → 576

DUSP; DUSP domain

pfam13499
Location:226 → 283

EF-hand_7; EF-hand domain pair

pfam14836
Location:627 → 714

Ubiquitin_3; Ubiquitin-like domain
XM_047436943.1 → XP_047292899.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X7
XM_047436944.1 → XP_047292900.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X10
XM_017025233.2 → XP_016880722.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X9

UniProtKB/TrEMBL

K7EQL6
XM_011525378.2 → XP_011523680.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X8

UniProtKB/TrEMBL

K7EQL6

Conserved Domains (6) summary

COG5560
Location:472 → 1284

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cd00051
Location:191 → 247

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl02553
Location:1193 → 1533

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam06337
Location:473 → 540

DUSP; DUSP domain

pfam13499
Location:190 → 247

EF-hand_7; EF-hand domain pair

pfam14836
Location:591 → 678

Ubiquitin_3; Ubiquitin-like domain
XM_011525379.4 → XP_011523681.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X11

UniProtKB/TrEMBL

K7EQL6

Conserved Domains (4) summary

COG5560
Location:227 → 1039

UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

cl02553
Location:948 → 1288

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam06337
Location:228 → 295

DUSP; DUSP domain

pfam14836
Location:346 → 433

Ubiquitin_3; Ubiquitin-like domain
XM_047436945.1 → XP_047292901.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X12

Related

ENSP00000467885.1, ENST00000592339.5

Alternate T2T-CHM13v2.0

Genomic

NC_060941.1 Alternate T2T-CHM13v2.0

Range

61046275..61291441 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054317567.1 → XP_054173542.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X2
XM_054317566.1 → XP_054173541.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X1
XM_054317571.1 → XP_054173546.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X6
XM_054317569.1 → XP_054173544.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X4
XM_054317568.1 → XP_054173543.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X3
XM_054317570.1 → XP_054173545.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X5
XM_054317572.1 → XP_054173547.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X7
XM_054317575.1 → XP_054173550.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X10
XM_054317574.1 → XP_054173549.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X9
XM_054317573.1 → XP_054173548.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X8
XM_054317576.1 → XP_054173551.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X11
XM_054317577.1 → XP_054173552.1 ubiquitin carboxyl-terminal hydrolase 32 isoform X12