PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPP1R2provided by HGNC
Official Full Name: protein phosphatase 1 regulatory inhibitor subunit 2provided by HGNC
Primary source: HGNC:HGNC:9288
See related: Ensembl:ENSG00000184203 MIM:601792; AllianceGenome:HGNC:9288
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IPP2; IPP-2; PPP1R2A
Summary: Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression: Ubiquitous expression in bone marrow (RPKM 27.3), testis (RPKM 22.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 3q29

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (195514428..195543325, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (198221391..198250329, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (195241224..195270148, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The PP1 regulator PPP1R2 coordinately regulates AURKA and PP1 to control centrosome phosphorylation and maintain central spindle architecture.
Title: The PP1 regulator PPP1R2 coordinately regulates AURKA and PP1 to control centrosome phosphorylation and maintain central spindle architecture.
The results show that contrary to initial observations PPP1R2-related pseudogenes are not simple bystanders of the evolutionary process but may rather be at the origin of genes with novel functions.
Title: Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes.
The potential phosphosites in PPP1R2 are substituted by non-phosphorylable residues, T73P and S87R, in PPP1R2P3.
Title: Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa.
Pin1 and phosphatase inhibitor-2 are conserved among eukaryotes from yeast to humans and make an ancient partnership that provides a means for regulating Pin1 specificity and function.
Title: Molecular basis for an ancient partnership between prolyl isomerase Pin1 and phosphatase inhibitor-2.
Results suggest that phosphatase inhibitor 2 localizes to the primary cilium of human retinal epithelial cells where it affects both Ser/Thr phosphorylation and is required for full tubulin acetylation.
Title: Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells.
Conserved together throughout eukaryotic evolution, I-2, PP1 and Aurora B function interdependently during mitosis.
Title: Phosphatase inhibitor-2 balances protein phosphatase 1 and aurora B kinase for chromosome segregation and cytokinesis in human retinal epithelial cells.
These results indicate that the protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation induced by KCl and that GSK3 activity regulates SERCA2 levels.
Title: The protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation and increases sarcoplasmic/endoplasmic reticulum calcium ATPase 2 levels.
first demonstration that glycogen synthase kinase-3beta associates with PP1C/I-2 complex and phosphorylates I-2 at T72 in intact cells
Title: Regulation of type 1 protein phosphatase/inhibitor-2 complex by glycogen synthase kinase-3beta in intact cells.
PP1C and Inh2 bind to KPI2 to form a regulatory complex that is localized to membranes
Title: A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2.
Inh2 can enhance the kinase activity of the Nek2.PP1C complex via inhibition of phosphatase activity to initiate centrosome separation
Title: Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH38934 (e-PCR)
- UniSTS:85520

G20795 (e-PCR)
- UniSTS:16712

A006H01 (e-PCR)
- UniSTS:16713

D3S2826E (e-PCR)
- UniSTS:150862

D5S2660 (e-PCR)
- UniSTS:22354

PPP1R2_1377 (e-PCR)
- UniSTS:277604

D3S2923E (e-PCR)
- UniSTS:150907

SHGC-12023 (e-PCR)
- UniSTS:46976

GDB:451568 (e-PCR)
- UniSTS:157313

WIAF-1664 (e-PCR)
- UniSTS:40155

RH17847 (e-PCR)
- UniSTS:79358

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables molecular function inhibitor activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase inhibitor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in generation of precursor metabolites and energy	TAS Traceable Author Statement more info	PubMed
involved_in glycogen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein phosphatase inhibitor 2

Names: phosphoprotein phosphatase

NP_001278433.1

EC 3.1.3.16

NP_001278434.1

EC 3.1.3.16

NP_001303254.1

EC 3.1.3.16

NP_006232.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291504.2 → NP_001278433.1 protein phosphatase inhibitor 2 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC069213

UniProtKB/TrEMBL

E7EMN6

Conserved Domains (1) summary

pfam04979
Location:45 → 164

IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
NM_001291505.2 → NP_001278434.1 protein phosphatase inhibitor 2 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC069213

UniProtKB/TrEMBL

E7EMN6

Related

ENSP00000400238.1, ENST00000438848.5

Conserved Domains (1) summary

pfam04979
Location:45 → 137

IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
NM_001316325.2 → NP_001303254.1 protein phosphatase inhibitor 2 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternate exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC069213, BC007655, BI560631

UniProtKB/Swiss-Prot

P41236

Conserved Domains (1) summary

pfam04979
Location:52 → 143

IPP-2; Protein phosphatase inhibitor 2 (IPP-2)
NM_006241.8 → NP_006232.1 protein phosphatase inhibitor 2 isoform 2

See identical proteins and their annotated locations for NP_006232.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AA259068, AC069213, BC007655

Consensus CDS

CCDS3309.1

UniProtKB/Swiss-Prot

P41236

UniProtKB/TrEMBL

E7EMN6

Related

ENSP00000484580.1, ENST00000618156.5

Conserved Domains (1) summary

pfam04979
Location:45 → 164

IPP-2; Protein phosphatase inhibitor 2 (IPP-2)

RNA

NR_133014.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC069213, BC007655, BI549862