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    LNCARSR lncRNA regulator of Akt signaling associated with HCC and RCC [ Homo sapiens (human) ]

    Gene ID: 102723932, updated on 22-Oct-2024

    Summary

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    Official Symbol
    LNCARSRprovided by HGNC
    Official Full Name
    lncRNA regulator of Akt signaling associated with HCC and RCCprovided by HGNC
    Primary source
    HGNC:HGNC:53864
    See related
    Ensembl:ENSG00000233086 AllianceGenome:HGNC:53864
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    lnc-TALC
    Expression
    Restricted expression toward testis (RPKM 2.2) See more
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    Genomic context

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    See LNCARSR in Genome Data Viewer
    Location:
    9q21.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (79517873..79567952, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (91676249..91726328, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (82132788..82182867, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1041 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 9 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:82053632-82054206 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:82054207-82054781 Neighboring gene uncharacterized LOC124902328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19968 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:82115206-82115783 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19970 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:82187809-82188421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19974 Neighboring gene VISTA enhancer hs1078 Neighboring gene uncharacterized LOC124902329 Neighboring gene TLE family member 4, transcriptional corepressor Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:82267149-82267908 Neighboring gene VISTA enhancer hs1360 Neighboring gene NANOG hESC enhancer GRCh37_chr9:82346165-82346666 Neighboring gene NANOG hESC enhancer GRCh37_chr9:82380198-82380813 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:82449531-82450161 Neighboring gene ankyrin repeat domain-containing protein 36B-like Neighboring gene long intergenic non-protein coding RNA 1507

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Renal cell carcinoma-derived exosomes deliver lncARSR to induce macrophage polarization and promote tumor progression via STAT3 pathway. Zhang W, et al. Int J Biol Sci, 2022. PMID 35637970, Free PMC Article
    2. Long noncoding RNA ARSR is associated with a poor prognosis in patients with colorectal cancer. Li T, et al. J Gene Med, 2020 Oct. PMID 32558022
    3. Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma. Xing Q, et al. Cancer Med, 2019 Jun. PMID 31038847, Free PMC Article
    4. Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA. Qu L, et al. Cancer Cell, 2016 May 9. PMID 27117758
    5. Lnc-TALC promotes O(6)-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p. Wu P, et al. Nat Commun, 2019 May 3. PMID 31053733, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Renal cell carcinoma-derived exosomes deliver lncARSR to induce macrophage polarization and promote tumor progression via STAT3 pathway.
      Title: Renal cell carcinoma-derived exosomes deliver lncARSR to induce macrophage polarization and promote tumor progression via STAT3 pathway.
    2. Long noncoding RNA ARSR is associated with a poor prognosis in patients with colorectal cancer.
      Title: Long noncoding RNA ARSR is associated with a poor prognosis in patients with colorectal cancer.
    3. lncARSR sponges miR-34a-5p to promote colorectal cancer invasion and metastasis via hexokinase-1-mediated glycolysis.
      Title: lncARSR sponges miR-34a-5p to promote colorectal cancer invasion and metastasis via hexokinase-1-mediated glycolysis.
    4. Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma.
      Title: Genetic variants in a long noncoding RNA related to Sunitinib Resistance predict risk and survival of patients with renal cell carcinoma.
    5. Data suggest that lncARSR (long non-coding RNA (lncRNA) activated in renal cell carcinoma (RCC) with sunitinib resistance) may serve as a predictor and a potential therapeutic target for sunitinib resistance.
      Title: Exosome-Transmitted lncARSR Promotes Sunitinib Resistance in Renal Cancer by Acting as a Competing Endogenous RNA.
    6. High lncARSR expression is associated with liver cancer.
      Title: lncARSR promotes liver cancer stem cells expansion via STAT3 pathway.
    7. lncARSR interacts with Yes-associated protein (YAP) to block its phosphorylation by LATS1, facilitating YAP nuclear translocation.
      Title: A feed-forward loop between lncARSR and YAP activity promotes expansion of renal tumour-initiating cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Other Names

    • lncRNA Activated in RCC with Sunitinib Resistance
    • temozolomide-associated lncRNA in glioblastoma recurrence

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_184110.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL358975
      Related
      ENST00000665514.1

    2. NR_184111.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL358975
      Related
      ENST00000656806.2

    3. NR_184112.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL358975
      Related
      ENST00000671232.2

    4. NR_184113.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL358975
      Related
      ENST00000670754.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      79517873..79567952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      91676249..91726328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials