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    C5orf58 chromosome 5 open reading frame 58 [ Homo sapiens (human) ]

    Gene ID: 133874, updated on 27-Nov-2024

    Summary

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    Official Symbol
    C5orf58provided by HGNC
    Official Full Name
    chromosome 5 open reading frame 58provided by HGNC
    Primary source
    HGNC:HGNC:37272
    See related
    Ensembl:ENSG00000234511 AllianceGenome:HGNC:37272
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in testis (RPKM 12.9), bone marrow (RPKM 2.8) and 5 other tissues See more
    Orthologs
    all
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    Genomic context

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    See C5orf58 in Genome Data Viewer
    Location:
    5q35.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (170232985..170252570)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (170771839..170791430)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (169659989..169679574)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 41 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:169581531-169582061 Neighboring gene long intergenic non-protein coding RNA 1187 Neighboring gene Sharpr-MPRA regulatory region 15284 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:169646378-169647577 Neighboring gene lymphocyte cytosolic protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23605 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:169730050-169731249 Neighboring gene uncharacterized LOC100128059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23606 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23607 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:169757700-169758899 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:169759699-169760548 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:169760549-169761396 Neighboring gene long intergenic non-protein coding RNA 1366

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. Navarini AA, et al. Nat Commun, 2014 Jun 13. PMID 24927181
    2. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC42229

    General protein information

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    Preferred Names
    putative uncharacterized protein C5orf58

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102609.3 → NP_001096079.2  putative uncharacterized protein C5orf58

      Status: VALIDATED

      Source sequence(s)
      AC008660, AC034199
      Consensus CDS
      CCDS47338.1
      UniProtKB/Swiss-Prot
      C9J3I9
      Related
      ENSP00000490013.2, ENST00000593851.5

    2. NM_001305393.2 → NP_001292322.2  putative uncharacterized protein C5orf58

      Status: VALIDATED

      Source sequence(s)
      AC008660, AC034199
      Consensus CDS
      CCDS47338.1
      UniProtKB/Swiss-Prot
      C9J3I9

    3. NM_001305394.2 → NP_001292323.2  putative uncharacterized protein C5orf58

      Status: VALIDATED

      Source sequence(s)
      AC008660, AC034199
      Consensus CDS
      CCDS47338.1
      UniProtKB/Swiss-Prot
      C9J3I9

    RNA

    1. NR_131091.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008660, AC034199
      Related
      ENST00000524171.5

    2. NR_131092.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008660, AC034199

    3. NR_161261.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008660, AC034199

    4. NR_161262.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008660, AC034199

    5. NR_161263.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008660, AC034199

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      170232985..170252570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416711.1 → XP_047272667.1  putative uncharacterized protein C5orf58 isoform X1

    2. XM_017009032.2 → XP_016864521.1  putative uncharacterized protein C5orf58 isoform X1

      UniProtKB/Swiss-Prot
      C9J3I9

    3. XM_047416712.1 → XP_047272668.1  putative uncharacterized protein C5orf58 isoform X2

      UniProtKB/Swiss-Prot
      C9J3I9

    4. XM_017009033.2 → XP_016864522.1  putative uncharacterized protein C5orf58 isoform X1

      UniProtKB/Swiss-Prot
      C9J3I9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      170771839..170791430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351607.1 → XP_054207582.1  putative uncharacterized protein C5orf58 isoform X1

    2. XM_054351609.1 → XP_054207584.1  putative uncharacterized protein C5orf58 isoform X2

      UniProtKB/Swiss-Prot
      C9J3I9

    3. XM_054351606.1 → XP_054207581.1  putative uncharacterized protein C5orf58 isoform X1

    4. XM_054351608.1 → XP_054207583.1  putative uncharacterized protein C5orf58 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C9J3I9.2 GenPept UniProtKB/Swiss-Prot:C9J3I9

    Gene LinkOut

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