APBB2 amyloid beta precursor protein binding family B member 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: APBB2provided by HGNC
Official Full Name: amyloid beta precursor protein binding family B member 2provided by HGNC
Primary source: HGNC:HGNC:582
See related: Ensembl:ENSG00000163697 MIM:602710; AllianceGenome:HGNC:582
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FE65L; FE65L1
Summary: The protein encoded by this gene interacts with the cytoplasmic domains of amyloid beta (A4) precursor protein and amyloid beta (A4) precursor-like protein 2. This protein contains two phosphotyrosine binding (PTB) domains, which are thought to function in signal transduction. Polymorphisms in this gene have been associated with Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Expression: Ubiquitous expression in fat (RPKM 13.0), thyroid (RPKM 11.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4p14-p13

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (40810027..41214542, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (40783978..41188337, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (40812044..41216559, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR2053p promotes lung cancer progression by targeting APBB2.
Title: miR‑205‑3p promotes lung cancer progression by targeting APBB2.
Hsa-miR-30a-3p attenuates gastric adenocarcinoma proliferation and metastasis via APBB2.
Title: Hsa-miR-30a-3p attenuates gastric adenocarcinoma proliferation and metastasis via APBB2.
In this genome-wide association study, variants at the APBB2 locus demonstrated differential association with primary open-angle glaucoma by ancestry.
Title: Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.
Genetic variants in the APBB2 gene were associated with use of amphetamine in opioid dependent patients under methadone maintenance treatment. The haplotype combinations further confirmed this observation, especially in the patients with a positive urine morphine test result. The major genotype and allele type carriers showed a two-time higher risk of amphetamine use than the minor allele type carriers.
Title: APBB2 is associated with amphetamine use and plasma beta-amyloids in patients receiving methadone maintenance treatment.
APBB2 was differentially expressed between Fibromyalgia patients and healthy controls.
Title: Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia.
results provide additional evidence of a genetic interaction between GSK3beta and APBB2 and further suggest that GSK3beta is involved in the pathophysiology of both of the primary neuropathologies of Alzheimer's disease
Title: GSK3β Interactions with Amyloid Genes: An Autopsy Verification and Extension.
The APBB2 rs13133980 G allele was over-represented in centenarians with severe cognitive impairment compared to individuals without this disability.
Title: APBB2 genetic polymorphisms are associated with severe cognitive impairment in centenarians.
Observational study of gene-disease association. (HuGE Navigator)
Title: An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
The differential processing of amyloid-beta precursor via secretase enzymes regulates the proliferation and differentiation of human embryonic stem cell.
Title: Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells.
The hCV1558625 G allele was over-represented in patients with onset under age 70 compared to controls in the same age range.
Title: Analysis of APBB2 gene polymorphisms in sporadic Alzheimer's disease.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan of dental caries in the permanent dentition. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-53092 (e-PCR)
- UniSTS:77069

D4S3272 (e-PCR)
- UniSTS:1294

SHGC-59621 (e-PCR)
- UniSTS:4370

STS-N27935 (e-PCR)
- UniSTS:74011

D4S2919 (e-PCR)
- UniSTS:75039

SHGC-142169 (e-PCR)
- UniSTS:171297

D4S3222 (e-PCR)
- UniSTS:17958

SHGC-148037 (e-PCR)
- UniSTS:176166

SHGC-149747 (e-PCR)
- UniSTS:177193

RH123352 (e-PCR)
- UniSTS:135728

APBB2_8203 (e-PCR)
- UniSTS:471346

D4S303 (e-PCR)
- UniSTS:65588

D4S174 (e-PCR), detects polymorphism
- UniSTS:3637

SHGC-51743 (e-PCR)
- UniSTS:13116

SHGC-59844 (e-PCR)
- UniSTS:54077

G63652 (e-PCR)
- UniSTS:140614

MARC_13889-13890:1007561323:1 (e-PCR)
- UniSTS:267595

SHGC-53076 (e-PCR)
- UniSTS:79181

SHGC-59600 (e-PCR)
- UniSTS:3152

SHGC-68079 (e-PCR)
- UniSTS:18769

G41963 (e-PCR)
- UniSTS:63061

D4S2651 (e-PCR)
- UniSTS:6743

D4S2546E (e-PCR)
- UniSTS:40793

RH102013 (e-PCR)
- UniSTS:96347

SHGC-50280 (e-PCR)
- UniSTS:12642

STS-R35307 (e-PCR)
- UniSTS:55398

SHGC-132009 (e-PCR)
- UniSTS:170602

D10S16 (e-PCR)
- UniSTS:155756

G33670 (e-PCR)
- UniSTS:36979

SHGC-59693 (e-PCR)
- UniSTS:42617

WI-16758 (e-PCR)
- UniSTS:63116

D4S308 (e-PCR)
- UniSTS:48022

SHGC-67216 (e-PCR)
- UniSTS:4774

SHGC-51476 (e-PCR)
- UniSTS:1972

D4S1333 (e-PCR)
- UniSTS:26554

D4S2573E (e-PCR)
- UniSTS:150979

1862 (e-PCR)
- UniSTS:62153

SHGC-78054 (e-PCR)
- UniSTS:101582

D4S999 (e-PCR)
- UniSTS:68304

SHGC-77808 (e-PCR)
- UniSTS:95960

SHGC-67240 (e-PCR)
- UniSTS:19932

D4S2536E (e-PCR)
- UniSTS:57335

RH118718 (e-PCR)
- UniSTS:109304

G34298 (e-PCR)
- UniSTS:47103

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables amyloid-beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in maintenance of lens transparency	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell cycle phase transition	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in synapse organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: amyloid beta precursor protein binding family B member 2

Names: Fe65-like 1; protein Fe65-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013337.1 RefSeqGene

Range

5077..409592

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001166050.2 → NP_001159522.1 amyloid beta precursor protein binding family B member 2 isoform b

See identical proteins and their annotated locations for NP_001159522.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.

Source sequence(s)

AC131953, AK295974, AK304247, AL080130, BC027946, DB236935

Consensus CDS

CCDS54761.1

UniProtKB/Swiss-Prot

B4DSL4, E9PG87, Q8IUI6, Q92870

UniProtKB/TrEMBL

B4E2F2

Related

ENSP00000295974.8, ENST00000295974.12

Conserved Domains (3) summary

cd01271
Location:582 → 708

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:416 → 553

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:292 → 320

WW; WW domain
NM_001166051.2 → NP_001159523.1 amyloid beta precursor protein binding family B member 2 isoform d

See identical proteins and their annotated locations for NP_001159523.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the presence and absence of exons in the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (d) is significantly shorter at the N-terminus, compared to isoform a. Variants 4, 5, 6 and 7 encode the same isoform.

Source sequence(s)

AC131953, AL080130, BU184203, BX440903, DC400218

Consensus CDS

CCDS54760.1

UniProtKB/Swiss-Prot

Q92870

Related

ENSP00000423765.1, ENST00000504305.5

Conserved Domains (1) summary

cd01271
Location:34 → 160

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
NM_001166052.2 → NP_001159524.1 amyloid beta precursor protein binding family B member 2 isoform d

See identical proteins and their annotated locations for NP_001159524.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the presence and absence of exons in the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (d) is significantly shorter at the N-terminus, compared to isoform a. Variants 4, 5, 6 and 7 encode the same isoform.

Source sequence(s)

AC131953, AK299800, AL080130, DC400218

Consensus CDS

CCDS54760.1

UniProtKB/Swiss-Prot

Q92870

Related

ENSP00000425802.1, ENST00000502841.5

Conserved Domains (1) summary

cd01271
Location:34 → 160

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
NM_001166053.1 → NP_001159525.1 amyloid beta precursor protein binding family B member 2 isoform d

See identical proteins and their annotated locations for NP_001159525.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the presence and absence of exons in the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (d) is significantly shorter at the N-terminus, compared to isoform a. Variants 4, 5, 6 and 7 encode the same isoform.

Source sequence(s)

AC131953, AL080130, CX782504, DC372060, DC377693

Consensus CDS

CCDS54760.1

UniProtKB/Swiss-Prot

Q92870

Conserved Domains (1) summary

cd01271
Location:34 → 160

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
NM_001166054.1 → NP_001159526.1 amyloid beta precursor protein binding family B member 2 isoform d

See identical proteins and their annotated locations for NP_001159526.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the presence and absence of exons in the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (d) is significantly shorter at the N-terminus, compared to isoform a. Variants 4, 5, 6 and 7 encode the same isoform.

Source sequence(s)

AC131953, AL080130, CX782504, DC372060, DC377357

Consensus CDS

CCDS54760.1

UniProtKB/Swiss-Prot

Q92870

Conserved Domains (1) summary

cd01271
Location:34 → 160

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
NM_001330656.2 → NP_001317585.1 amyloid beta precursor protein binding family B member 2 isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (9) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (e) that is shorter than isoform a. Variants 8 and 9 encode the same isoform.

Source sequence(s)

AC093804, AC131953, AL080130, BC027946, BC088372, DB078521, DB236935

Consensus CDS

CCDS82918.1

UniProtKB/TrEMBL

G5E9Y1, H0YAJ5

Related

ENSP00000421539.1, ENST00000506352.5

Conserved Domains (3) summary

cd01271
Location:561 → 687

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:395 → 532

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:292 → 320

WW; WW domain
NM_001330658.2 → NP_001317587.1 amyloid beta precursor protein binding family B member 2 isoform e

Status: REVIEWED

Description

Transcript Variant: This variant (8) lacks an exon in the 5' UTR, uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (e) that is shorter than isoform a. Variants 8 and 9 encode the same isoform.

Source sequence(s)

AC093804, AC131953, AL080130, AL596608, BC027946, BC088372

Consensus CDS

CCDS82918.1

UniProtKB/TrEMBL

G5E9Y1, H0YAJ5

Conserved Domains (3) summary

cd01271
Location:561 → 687

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:395 → 532

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:292 → 320

WW; WW domain
NM_004307.2 → NP_004298.1 amyloid beta precursor protein binding family B member 2 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC131953, AK226179, AK295974, AL080130, DB236935

Consensus CDS

CCDS54762.1

UniProtKB/TrEMBL

B4E2F2

Related

ENSP00000427211.1, ENST00000508593.6

Conserved Domains (3) summary

cd01271
Location:583 → 709

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:417 → 554

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:293 → 321

WW; WW domain
NM_173075.5 → NP_775098.2 amyloid beta precursor protein binding family B member 2 isoform c

See identical proteins and their annotated locations for NP_775098.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses two alternate in-frame splice sites and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a.

Source sequence(s)

AC093804, AC131953, AL080130, BC027946, DB236935

Consensus CDS

CCDS43224.1

UniProtKB/TrEMBL

H0YAJ5

Related

ENSP00000426018.1, ENST00000513140.5

Conserved Domains (3) summary

cd01271
Location:560 → 686

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:395 → 532

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:292 → 320

WW; WW domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

40810027..41214542 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047450191.1 → XP_047306147.1 amyloid beta precursor protein binding family B member 2 isoform X9

UniProtKB/TrEMBL

G5E9Y1, H0YAJ5
XM_047450181.1 → XP_047306137.1 amyloid beta precursor protein binding family B member 2 isoform X4

UniProtKB/Swiss-Prot

B4DSL4, E9PG87, Q8IUI6, Q92870

UniProtKB/TrEMBL

B4E2F2
XM_047450169.1 → XP_047306125.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2
XM_047450187.1 → XP_047306143.1 amyloid beta precursor protein binding family B member 2 isoform X8

UniProtKB/TrEMBL

H0YAJ5
XM_047450175.1 → XP_047306131.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2
XM_047450164.1 → XP_047306120.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_047450190.1 → XP_047306146.1 amyloid beta precursor protein binding family B member 2 isoform X9

UniProtKB/TrEMBL

G5E9Y1, H0YAJ5
XM_047450184.1 → XP_047306140.1 amyloid beta precursor protein binding family B member 2 isoform X7

UniProtKB/TrEMBL

H0YAJ5
XM_047450180.1 → XP_047306136.1 amyloid beta precursor protein binding family B member 2 isoform X4

UniProtKB/Swiss-Prot

B4DSL4, E9PG87, Q8IUI6, Q92870

UniProtKB/TrEMBL

B4E2F2
XM_047450166.1 → XP_047306122.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2
XM_047450186.1 → XP_047306142.1 amyloid beta precursor protein binding family B member 2 isoform X8

UniProtKB/TrEMBL

H0YAJ5
XM_047450173.1 → XP_047306129.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2
XM_047450161.1 → XP_047306117.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_047450183.1 → XP_047306139.1 amyloid beta precursor protein binding family B member 2 isoform X7

UniProtKB/TrEMBL

H0YAJ5
XM_047450179.1 → XP_047306135.1 amyloid beta precursor protein binding family B member 2 isoform X4

UniProtKB/Swiss-Prot

B4DSL4, E9PG87, Q8IUI6, Q92870

UniProtKB/TrEMBL

B4E2F2
XM_047450170.1 → XP_047306126.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2
XM_047450172.1 → XP_047306128.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2
XM_047450159.1 → XP_047306115.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_017008148.3 → XP_016863637.1 amyloid beta precursor protein binding family B member 2 isoform X5

UniProtKB/TrEMBL

B4E2F2
XM_017008152.3 → XP_016863641.1 amyloid beta precursor protein binding family B member 2 isoform X7

UniProtKB/TrEMBL

H0YAJ5

Conserved Domains (3) summary

cd01271
Location:563 → 689

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:395 → 534

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:292 → 320

WW; WW domain
XM_047450178.1 → XP_047306134.1 amyloid beta precursor protein binding family B member 2 isoform X4

UniProtKB/Swiss-Prot

B4DSL4, E9PG87, Q8IUI6, Q92870

UniProtKB/TrEMBL

B4E2F2
XM_017008144.3 → XP_016863633.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2

Conserved Domains (3) summary

cd01271
Location:584 → 710

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:416 → 555

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:292 → 320

WW; WW domain
XM_017008154.3 → XP_016863643.1 amyloid beta precursor protein binding family B member 2 isoform X8

UniProtKB/TrEMBL

H0YAJ5

Conserved Domains (3) summary

cd01271
Location:562 → 688

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:396 → 533

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:293 → 321

WW; WW domain
XM_017008151.3 → XP_016863640.1 amyloid beta precursor protein binding family B member 2 isoform X6

UniProtKB/TrEMBL

H0YAJ5

Conserved Domains (3) summary

cd01271
Location:564 → 690

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:396 → 535

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:293 → 321

WW; WW domain
XM_017008145.3 → XP_016863634.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2

Conserved Domains (3) summary

cd01271
Location:583 → 709

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:417 → 554

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:293 → 321

WW; WW domain
XM_006714008.5 → XP_006714071.1 amyloid beta precursor protein binding family B member 2 isoform X1

See identical proteins and their annotated locations for XP_006714071.1

UniProtKB/TrEMBL

B4E2F2

Conserved Domains (3) summary

cd01271
Location:585 → 711

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:417 → 556

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:293 → 321

WW; WW domain
XM_017008146.3 → XP_016863635.1 amyloid beta precursor protein binding family B member 2 isoform X5

UniProtKB/TrEMBL

B4E2F2
XM_006714012.5 → XP_006714075.1 amyloid beta precursor protein binding family B member 2 isoform X7

UniProtKB/TrEMBL

H0YAJ5

Conserved Domains (3) summary

cd01271
Location:563 → 689

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:395 → 534

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:292 → 320

WW; WW domain
XM_006714010.5 → XP_006714073.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2

Conserved Domains (3) summary

cd01271
Location:584 → 710

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:416 → 555

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:292 → 320

WW; WW domain
XM_011513687.4 → XP_011511989.1 amyloid beta precursor protein binding family B member 2 isoform X8

UniProtKB/TrEMBL

H0YAJ5

Conserved Domains (3) summary

cd01271
Location:562 → 688

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:396 → 533

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:293 → 321

WW; WW domain
XM_006714011.5 → XP_006714074.1 amyloid beta precursor protein binding family B member 2 isoform X6

UniProtKB/TrEMBL

H0YAJ5

Conserved Domains (3) summary

cd01271
Location:564 → 690

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:396 → 535

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:293 → 321

WW; WW domain
XM_006714005.5 → XP_006714068.1 amyloid beta precursor protein binding family B member 2 isoform X1

See identical proteins and their annotated locations for XP_006714068.1

UniProtKB/TrEMBL

B4E2F2

Conserved Domains (3) summary

cd01271
Location:585 → 711

PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain

cd01272
Location:417 → 556

PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

pfam00397
Location:293 → 321

WW; WW domain
XM_047450163.1 → XP_047306119.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_047450168.1 → XP_047306124.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2
XM_047450174.1 → XP_047306130.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2
XM_047450162.1 → XP_047306118.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_047450189.1 → XP_047306145.1 amyloid beta precursor protein binding family B member 2 isoform X9

UniProtKB/TrEMBL

G5E9Y1, H0YAJ5
XM_047450182.1 → XP_047306138.1 amyloid beta precursor protein binding family B member 2 isoform X7

UniProtKB/TrEMBL

H0YAJ5
XM_047450177.1 → XP_047306133.1 amyloid beta precursor protein binding family B member 2 isoform X4

UniProtKB/Swiss-Prot

B4DSL4, E9PG87, Q8IUI6, Q92870

UniProtKB/TrEMBL

B4E2F2
XM_047450167.1 → XP_047306123.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2
XM_047450185.1 → XP_047306141.1 amyloid beta precursor protein binding family B member 2 isoform X8

UniProtKB/TrEMBL

H0YAJ5
XM_047450171.1 → XP_047306127.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2
XM_047450160.1 → XP_047306116.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_047450188.1 → XP_047306144.1 amyloid beta precursor protein binding family B member 2 isoform X8

UniProtKB/TrEMBL

H0YAJ5

Related

ENSP00000427307.1, ENST00000513611.5
XM_047450176.1 → XP_047306132.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2
XM_047450165.1 → XP_047306121.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

40783978..41188337 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054349910.1 → XP_054205885.1 amyloid beta precursor protein binding family B member 2 isoform X9

UniProtKB/TrEMBL

H0YAJ5
XM_054349892.1 → XP_054205867.1 amyloid beta precursor protein binding family B member 2 isoform X4

UniProtKB/TrEMBL

B4E2F2
XM_054349879.1 → XP_054205854.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2
XM_054349906.1 → XP_054205881.1 amyloid beta precursor protein binding family B member 2 isoform X8

UniProtKB/TrEMBL

H0YAJ5
XM_054349886.1 → XP_054205861.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2
XM_054349872.1 → XP_054205847.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_054349909.1 → XP_054205884.1 amyloid beta precursor protein binding family B member 2 isoform X9

UniProtKB/TrEMBL

H0YAJ5
XM_054349901.1 → XP_054205876.1 amyloid beta precursor protein binding family B member 2 isoform X7

UniProtKB/TrEMBL

H0YAJ5
XM_054349891.1 → XP_054205866.1 amyloid beta precursor protein binding family B member 2 isoform X4

UniProtKB/TrEMBL

B4E2F2
XM_054349875.1 → XP_054205850.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2
XM_054349905.1 → XP_054205880.1 amyloid beta precursor protein binding family B member 2 isoform X8

UniProtKB/TrEMBL

H0YAJ5
XM_054349884.1 → XP_054205859.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2
XM_054349869.1 → XP_054205844.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_054349900.1 → XP_054205875.1 amyloid beta precursor protein binding family B member 2 isoform X7

UniProtKB/TrEMBL

H0YAJ5
XM_054349890.1 → XP_054205865.1 amyloid beta precursor protein binding family B member 2 isoform X4

UniProtKB/TrEMBL

B4E2F2
XM_054349880.1 → XP_054205855.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2
XM_054349883.1 → XP_054205858.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2
XM_054349867.1 → XP_054205842.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_054349894.1 → XP_054205869.1 amyloid beta precursor protein binding family B member 2 isoform X5

UniProtKB/TrEMBL

B4E2F2
XM_054349899.1 → XP_054205874.1 amyloid beta precursor protein binding family B member 2 isoform X7

UniProtKB/TrEMBL

H0YAJ5
XM_054349889.1 → XP_054205864.1 amyloid beta precursor protein binding family B member 2 isoform X4

UniProtKB/TrEMBL

B4E2F2
XM_054349876.1 → XP_054205851.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2
XM_054349904.1 → XP_054205879.1 amyloid beta precursor protein binding family B member 2 isoform X8

UniProtKB/TrEMBL

H0YAJ5
XM_054349896.1 → XP_054205871.1 amyloid beta precursor protein binding family B member 2 isoform X6

UniProtKB/TrEMBL

H0YAJ5
XM_054349881.1 → XP_054205856.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2
XM_054349866.1 → XP_054205841.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_054349893.1 → XP_054205868.1 amyloid beta precursor protein binding family B member 2 isoform X5

UniProtKB/TrEMBL

B4E2F2
XM_054349897.1 → XP_054205872.1 amyloid beta precursor protein binding family B member 2 isoform X7

UniProtKB/TrEMBL

H0YAJ5
XM_054349874.1 → XP_054205849.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2
XM_054349902.1 → XP_054205877.1 amyloid beta precursor protein binding family B member 2 isoform X8

UniProtKB/TrEMBL

H0YAJ5
XM_054349895.1 → XP_054205870.1 amyloid beta precursor protein binding family B member 2 isoform X6

UniProtKB/TrEMBL

H0YAJ5
XM_054349865.1 → XP_054205840.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_054349871.1 → XP_054205846.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_054349878.1 → XP_054205853.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2
XM_054349885.1 → XP_054205860.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2
XM_054349870.1 → XP_054205845.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_054349908.1 → XP_054205883.1 amyloid beta precursor protein binding family B member 2 isoform X9

UniProtKB/TrEMBL

H0YAJ5
XM_054349898.1 → XP_054205873.1 amyloid beta precursor protein binding family B member 2 isoform X7

UniProtKB/TrEMBL

H0YAJ5
XM_054349888.1 → XP_054205863.1 amyloid beta precursor protein binding family B member 2 isoform X4

UniProtKB/TrEMBL

B4E2F2
XM_054349877.1 → XP_054205852.1 amyloid beta precursor protein binding family B member 2 isoform X2

UniProtKB/TrEMBL

B4E2F2
XM_054349903.1 → XP_054205878.1 amyloid beta precursor protein binding family B member 2 isoform X8

UniProtKB/TrEMBL

H0YAJ5
XM_054349882.1 → XP_054205857.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2
XM_054349868.1 → XP_054205843.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_054349873.1 → XP_054205848.1 amyloid beta precursor protein binding family B member 2 isoform X1

UniProtKB/TrEMBL

B4E2F2
XM_054349907.1 → XP_054205882.1 amyloid beta precursor protein binding family B member 2 isoform X8

UniProtKB/TrEMBL

H0YAJ5
XM_054349887.1 → XP_054205862.1 amyloid beta precursor protein binding family B member 2 isoform X3

UniProtKB/TrEMBL

B4E2F2