Wnt2 wingless-type MMTV integration site family, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Wnt2provided by MGI
Official Full Name: wingless-type MMTV integration site family, member 2provided by MGI
Primary source: MGI:MGI:98954
See related: Ensembl:ENSMUSG00000010797 AllianceGenome:MGI:98954
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Irp; Mirp; Wnt-2; Wnt2a; Int1l1; 2610510E18Rik
Summary: Predicted to enable cytokine activity and frizzled binding activity. Involved in cell proliferation in midbrain and positive regulation of neurogenesis. Acts upstream of or within several processes, including circulatory system development; lung induction; and positive regulation of cell population proliferation. Predicted to be located in collagen-containing extracellular matrix; cytoplasm; and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including embryo mesenchyme; heart and pericardium; reproductive system; upper jaw primordium; and urethra. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in bladder adult (RPKM 7.8), lung adult (RPKM 3.1) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A2; 6 8.08 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (17988939..18032771, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (17985474..18032772, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway.
Title: Ursodesoxycholic acid alleviates liver fibrosis via proregeneration by activation of the ID1-WNT2/HGF signaling pathway.
Transient expression of WNT2 promotes somatic cell reprogramming by inducing beta-catenin nuclear accumulation.
Title: Transient Expression of WNT2 Promotes Somatic Cell Reprogramming by Inducing β-Catenin Nuclear Accumulation.
Study indicates essential roles for Wnt2 and Wnt3 in chronic restraint stress-induced depression-like behaviors and antidepressant.
Title: The antidepressant roles of Wnt2 and Wnt3 in stress-induced depression-like behaviors.
Upregulation of Wnt2 expression enhanced WISP-1 and promoted vascular smooth muscle cell migration and intimal thickening.
Title: Wnt2 and WISP-1/CCN4 Induce Intimal Thickening via Promotion of Smooth Muscle Cell Migration.
Wnt 2 levels were markedly down-regulated by retinoic acid in pancreatic stellar cells and chronic pancreatitis.
Title: Retinoic Acid Ameliorates Pancreatic Fibrosis and Inhibits the Activation of Pancreatic Stellate Cells in Mice with Experimental Chronic Pancreatitis via Suppressing the Wnt/β-Catenin Signaling Pathway.
We propose that the WNT2/CTNNB1 pathway regulates CX43 expression and gap junction intercellular communication in granulosa cells by modulating CTNNB1 stability and localization in adherens junctions
Title: The canonical WNT2 pathway and FSH interact to regulate gap junction assembly in mouse granulosa cells.
Pdgf signaling potentiates Wnt2-Wnt7b signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung
Title: Wnt ligands signal in a cooperative manner to promote foregut organogenesis.
Expression of WNT2 in pancreatic cancer cells suppresses anoikis, enhances anchorage-independent sphere formation, and increases metastatic propensity in vivo.
Title: RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis.
Wnt2 plays strong positive stage-specific role in cardiogenesis through non-canonical Wnt pathway in murine ES cells.
Title: Wnt2 accelerates cardiac myocyte differentiation from ES-cell derived mesodermal cells via non-canonical pathway.
show that Wnt2 signaling is necessary and sufficient for activation of a transcriptional and signaling network critical for smooth muscle specification and differentiation including myocardin/Mrtf-B and the signaling factor Fgf10
Title: Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Wnt2 (e-PCR), detects polymorphism
- UniSTS:471321

Wnt2 (e-PCR), detects polymorphism
- UniSTS:508441

Wnt2 (e-PCR), detects polymorphism
- UniSTS:527135

Wnt2 (e-PCR), detects polymorphism
- UniSTS:254326

Wnt2 (e-PCR), detects polymorphism
- UniSTS:254327

Wnt2 (e-PCR), detects polymorphism
- UniSTS:144775

Wnt2 (e-PCR), detects polymorphism
- UniSTS:516491

G49397 (e-PCR)
- UniSTS:109208

Wnt2 (e-PCR), detects polymorphism
- UniSTS:507315

Wnt2 (e-PCR), detects polymorphism
- UniSTS:508410

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables cytokine activity	ISO Inferred from Sequence Orthology more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IEA Inferred from Electronic Annotation more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within atrial cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac epithelial to mesenchymal transition	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell proliferation in midbrain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell proliferation in midbrain	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	IEA Inferred from Electronic Annotation more info
involved_in cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of epithelial cell proliferation involved in lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lung induction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mammary gland epithelium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midbrain dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in midbrain dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein Wnt-2

Names: INT-1-related protein; wingless-related MMTV integration site 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023653.5 → NP_076142.3 protein Wnt-2 precursor

Status: VALIDATED

Source sequence(s)

AC068561, AK012093, AK045120

Consensus CDS

CCDS19928.1

UniProtKB/Swiss-Prot

P21552, Q9CZW3

UniProtKB/TrEMBL

Q3TJ02, Q8BRC7

Related

ENSMUSP00000010941.3, ENSMUST00000010941.6

Conserved Domains (1) summary

pfam00110
Location:43 → 349

wnt; wnt family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

17988939..18032771 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505045.4 → XP_006505108.1 protein Wnt-2 isoform X1

UniProtKB/TrEMBL

Q3TJ02, Q8BRC7

Conserved Domains (1) summary

cd19345
Location:44 → 357

Wnt_Wnt2; Wnt domain found in protein Wnt-2 and similar proteins