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    MTSS1 MTSS I-BAR domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 9788, updated on 26-Nov-2024

    Summary

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    Official Symbol
    MTSS1provided by HGNC
    Official Full Name
    MTSS I-BAR domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:20443
    See related
    Ensembl:ENSG00000170873 MIM:608486; AllianceGenome:HGNC:20443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIM; MIMA; MIMB
    Summary
    Enables actin monomer binding activity; identical protein binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including adherens junction maintenance; positive regulation of actin filament bundle assembly; and renal tubule development. Predicted to act upstream of or within several processes, including actin filament polymerization; bone mineralization; and magnesium ion homeostasis. Located in actin cytoskeleton. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver (RPKM 5.7), adrenal (RPKM 5.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MTSS1 in Genome Data Viewer
    Location:
    8q24.13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (124550784..124728473, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (125683798..125861532, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (125563025..125740714, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene TatD DNase domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27884 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27885 Neighboring gene microRNA 6844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19514 Neighboring gene NADH:ubiquinone oxidoreductase subunit B9 Neighboring gene uncharacterized LOC105375740 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27888 Neighboring gene uncharacterized LOC124902016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27889 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:125632749-125633948 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:125638519-125639718 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27892 Neighboring gene Sharpr-MPRA regulatory region 10356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27893 Neighboring gene Sharpr-MPRA regulatory region 2678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27895 Neighboring gene Sharpr-MPRA regulatory region 8202 Neighboring gene uncharacterized LOC105375741 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:125764038-125764579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:125810571-125811072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:125811073-125811572 Neighboring gene microRNA 4662b Neighboring gene microRNA 4662a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B. Bompard G, et al. J Cell Sci, 2005 Nov 15. PMID 16280553
    2. Reduced Expression of Metastasis Suppressor-1 (MTSS1) Accelerates Progression of Human Bladder Uroepithelium Cell Carcinoma. Du P, et al. Anticancer Res, 2017 Aug. PMID 28739745
    3. Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma. Wang H, et al. Acta Biochim Biophys Sin (Shanghai), 2017 Mar 1. PMID 28159994
    4. Loss of MTSS1 results in increased metastatic potential in pancreatic cancer. Zeleniak AE, et al. Oncotarget, 2017 Mar 7. PMID 28146435, Free PMC Article
    5. Effect of metastasis suppressor 1 on H1299 cells and its clinical significance in non-small cell lung cancer. Zhao H, et al. Oncol Rep, 2016 Nov. PMID 27634022

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mechanisms behind the dual role of long non-coding RNA (lncRNA) metastasis suppressor-1 in human tumors: Shedding light on the molecular mechanisms.
      Title: The mechanisms behind the dual role of long non-coding RNA (lncRNA) metastasis suppressor-1 in human tumors: Shedding light on the molecular mechanisms.
    2. Prognostic value of MTSS1 gene expression on acute leukemia patients outcome.
      Title: Prognostic value of MTSS1 gene expression on acute leukemia patients outcome.
    3. Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-delta to regulate adipogenesis.
      Title: Metastasis suppressor 1 interacts with protein tyrosine phosphatase receptor-δ to regulate adipogenesis.
    4. MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination.
      Title: MTSS1 suppresses mammary tumor-initiating cells by enhancing RBCK1-mediated p65 ubiquitination.
    5. Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness.
      Title: Downregulation of MTSS1 in acute myeloid leukemia is associated with a poor prognosis, chemotherapy resistance, and disease aggressiveness.
    6. Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway.
      Title: Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway.
    7. Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis.
      Title: Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis.
    8. A reciprocal feedback of Myc and lncRNA MTSS1-AS contributes to extracellular acidity-promoted metastasis of pancreatic cancer.
      Title: A reciprocal feedback of Myc and lncRNA MTSS1-AS contributes to extracellular acidity-promoted metastasis of pancreatic cancer.
    9. MicroRNA-182-5p Modulates Oral Squamous Cell Carcinoma Migration and Invasion Via Targeting MTSS1 Gene.
      Title: MicroRNA-182-5p Modulates Oral Squamous Cell Carcinoma Migration and Invasion Via Targeting MTSS1 Gene.
    10. miR-28-5p targets MTSS1 to regulate cell proliferation and apoptosis in esophageal cancer.
      Title: miR-28-5p targets MTSS1 to regulate cell proliferation and apoptosis in esophageal cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (66)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin monomer binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adherens junction maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell adhesion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular response to fluid shear stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in epithelial cell proliferation involved in renal tubule morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glomerulus morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microspike assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of epithelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nephron tubule epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in plasma membrane organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in renal tubule morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endocytic vesicle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in ruffle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein MTSS 1
    Names
    MTSS1, I-BAR domain containing
    metastasis suppressor 1
    metastasis suppressor YGL-1
    metastasis suppressor protein 1
    missing in metastasis protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282971.2 → NP_001269900.1  protein MTSS 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC090198, AJ710067, AK027015, DA790325
      Consensus CDS
      CCDS64969.1
      UniProtKB/TrEMBL
      A5YM41
      Related
      ENSP00000322804.5, ENST00000325064.9
      Conserved Domains (3) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:330 → 729
      PHA03247; large tegument protein UL36; Provisional
      cd22060
      Location:728 → 758
      WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

    2. NM_001282974.2 → NP_001269903.1  protein MTSS 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
      Source sequence(s)
      AC090198, AF086645, AJ710067, DA790325, EF560715
      Consensus CDS
      CCDS64968.1
      UniProtKB/TrEMBL
      A5YM41
      Related
      ENSP00000367256.3, ENST00000378017.7
      Conserved Domains (3) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:400 → 700
      PHA03247; large tegument protein UL36; Provisional
      cd22060
      Location:699 → 729
      WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

    3. NM_001363294.2 → NP_001350223.1  protein MTSS 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC090198, AF086645, AJ710067, CN348724, DA790325
      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (3) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:723 → 749
      WH2; WH2 motif
      cl26464
      Location:325 → 724
      Atrophin-1; Atrophin-1 family

    4. NM_001363295.2 → NP_001350224.1  protein MTSS 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC090198, AF086645, AJ710067, DA447614, DA790325
      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (3) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:326 → 708
      PHA03247; large tegument protein UL36; Provisional
      cd22060
      Location:707 → 737
      WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

    5. NM_001363296.2 → NP_001350225.1  protein MTSS 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC090198, AJ710067, AK027015, BY993850, DA227466, DA785323, DA790325
      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (3) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:404 → 704
      PHA03247; large tegument protein UL36; Provisional
      cd22060
      Location:703 → 733
      WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

    6. NM_001363297.2 → NP_001350226.1  protein MTSS 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC090198, AJ710067, AK027015, BY993850, DA227466, DA785323, DA790325
      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (4) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:567 → 695
      Gag_spuma; Spumavirus gag protein
      pfam02205
      Location:702 → 728
      WH2; WH2 motif
      cl26464
      Location:403 → 703
      Atrophin-1; Atrophin-1 family

    7. NM_001363298.2 → NP_001350227.1  protein MTSS 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC090198, AJ710067, AK027015, BY993850, DA225605, DA227466, DA785323, DA790325
      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (4) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:563 → 691
      Gag_spuma; Spumavirus gag protein
      pfam02205
      Location:698 → 724
      WH2; WH2 motif
      cl26464
      Location:399 → 699
      Atrophin-1; Atrophin-1 family

    8. NM_001363299.2 → NP_001350228.1  protein MTSS 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502
      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      cl26464
      Location:338 → 664
      Atrophin-1; Atrophin-1 family

    9. NM_001363300.2 → NP_001350229.1  protein MTSS 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502
      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      cl26464
      Location:334 → 660
      Atrophin-1; Atrophin-1 family

    10. NM_001363301.2 → NP_001350230.1  protein MTSS 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC090198, AJ710067, AK027015, BU145296, BY993850, DA785323, DA790325, HY339502
      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (3) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam02205
      Location:658 → 684
      WH2; WH2 motif
      cl26464
      Location:333 → 659
      Atrophin-1; Atrophin-1 family

    11. NM_001363302.2 → NP_001350231.1  protein MTSS 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC090198, AF086645, AJ710067, DA790325
      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      cl26464
      Location:326 → 644
      Atrophin-1; Atrophin-1 family

    12. NM_014751.6 → NP_055566.3  protein MTSS 1 isoform 2

      See identical proteins and their annotated locations for NP_055566.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC090198, AF086645, AJ710067, DA790325
      Consensus CDS
      CCDS6353.1
      UniProtKB/Swiss-Prot
      J3KNK6, O43312, Q8TCA2, Q96RX2
      UniProtKB/TrEMBL
      A5YM41
      Related
      ENSP00000429064.1, ENST00000518547.6
      Conserved Domains (3) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:326 → 725
      PHA03247; large tegument protein UL36; Provisional
      cd22060
      Location:724 → 754
      WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      124550784..124728473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047422493.1 → XP_047278449.1  protein MTSS 1 isoform X22

    2. XM_047422490.1 → XP_047278446.1  protein MTSS 1 isoform X18

    3. XM_017014086.3 → XP_016869575.1  protein MTSS 1 isoform X4

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:697 → 825
      Gag_spuma; Spumavirus gag protein

    4. XM_017014089.3 → XP_016869578.1  protein MTSS 1 isoform X8

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:672 → 800
      Gag_spuma; Spumavirus gag protein

    5. XM_017014092.3 → XP_016869581.1  protein MTSS 1 isoform X13

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:633 → 761
      Gag_spuma; Spumavirus gag protein

    6. XM_006716701.3 → XP_006716764.1  protein MTSS 1 isoform X3

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:698 → 826
      Gag_spuma; Spumavirus gag protein

    7. XM_017014088.3 → XP_016869577.1  protein MTSS 1 isoform X7

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 237
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:673 → 801
      Gag_spuma; Spumavirus gag protein

    8. XM_047422492.1 → XP_047278448.1  protein MTSS 1 isoform X20

    9. XM_006716704.3 → XP_006716767.1  protein MTSS 1 isoform X16

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:329 → 728
      PHA03247; large tegument protein UL36; Provisional

    10. XM_006716700.3 → XP_006716763.1  protein MTSS 1 isoform X2

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:701 → 829
      Gag_spuma; Spumavirus gag protein

    11. XM_006716706.3 → XP_006716769.1  protein MTSS 1 isoform X21

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:341 → 647
      PHA03247; large tegument protein UL36; Provisional

    12. XM_006716703.3 → XP_006716766.1  protein MTSS 1 isoform X15

      Conserved Domains (3) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:330 → 756
      PHA03247; large tegument protein UL36; Provisional
      pfam03276
      Location:620 → 748
      Gag_spuma; Spumavirus gag protein

    13. XM_005251113.3 → XP_005251170.1  protein MTSS 1 isoform X11

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:637 → 765
      Gag_spuma; Spumavirus gag protein

    14. XM_006716705.3 → XP_006716768.1  protein MTSS 1 isoform X17

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (3) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      PHA03247
      Location:330 → 712
      PHA03247; large tegument protein UL36; Provisional
      cd22060
      Location:711 → 741
      WH2_MTSS1; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Metastasis suppressor protein 1 (MTSS-1)

    15. XM_006716702.3 → XP_006716765.1  protein MTSS 1 isoform X5

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:685 → 813
      Gag_spuma; Spumavirus gag protein

    16. XM_005251111.3 → XP_005251168.1  protein MTSS 1 isoform X1

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:702 → 830
      Gag_spuma; Spumavirus gag protein

    17. XM_017014087.3 → XP_016869576.1  protein MTSS 1 isoform X6

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      cd07643
      Location:7 → 241
      I-BAR_IMD_MIM; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Missing In Metastasis
      pfam03276
      Location:677 → 805
      Gag_spuma; Spumavirus gag protein

    18. XM_011517403.2 → XP_011515705.1  protein MTSS 1 isoform X12

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      pfam03276
      Location:635 → 763
      Gag_spuma; Spumavirus gag protein
      cl12013
      Location:1 → 174
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    19. XM_017014091.2 → XP_016869580.1  protein MTSS 1 isoform X10

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      pfam03276
      Location:639 → 767
      Gag_spuma; Spumavirus gag protein
      cl12013
      Location:1 → 178
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    20. XM_047422491.1 → XP_047278447.1  protein MTSS 1 isoform X19

      Related
      ENSP00000428319.1, ENST00000524090.5

    21. XM_017014090.3 → XP_016869579.1  protein MTSS 1 isoform X9

      UniProtKB/TrEMBL
      A5YM41
      Conserved Domains (2) summary
      pfam03276
      Location:647 → 775
      Gag_spuma; Spumavirus gag protein
      cl12013
      Location:15 → 186
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

    22. XM_047422488.1 → XP_047278444.1  protein MTSS 1 isoform X14

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791784.1 Reference GRCh38.p14 PATCHES

      Range
      85734..103488 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      125683798..125861532 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361614.1 → XP_054217589.1  protein MTSS 1 isoform X22

    2. XM_054361610.1 → XP_054217585.1  protein MTSS 1 isoform X18

    3. XM_054361612.1 → XP_054217587.1  protein MTSS 1 isoform X20

    4. XM_054361608.1 → XP_054217583.1  protein MTSS 1 isoform X16

    5. XM_054361613.1 → XP_054217588.1  protein MTSS 1 isoform X21

    6. XM_054361609.1 → XP_054217584.1  protein MTSS 1 isoform X17

    7. XM_054361611.1 → XP_054217586.1  protein MTSS 1 isoform X19

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43312.2 GenPept UniProtKB/Swiss-Prot:O43312

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