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    SPMIP5 sperm microtubule inner protein 5 [ Homo sapiens (human) ]

    Gene ID: 143379, updated on 26-Nov-2024

    Summary

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    Official Symbol
    SPMIP5provided by HGNC
    Official Full Name
    sperm microtubule inner protein 5provided by HGNC
    Primary source
    HGNC:HGNC:28500
    See related
    Ensembl:ENSG00000165863 AllianceGenome:HGNC:28500
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C10orf82
    Summary
    Predicted to be located in several cellular components, including cytoskeleton; motile cilium; and nucleus. Predicted to be active in axonemal A tubule inner sheath. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis (RPKM 14.6), ovary (RPKM 2.0) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See SPMIP5 in Genome Data Viewer
    Location:
    10q25.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (116662211..116670282, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (117556531..117564614, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118421722..118429793, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902510 Neighboring gene pancreatic lipase related protein 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:118393650-118394849 Neighboring gene pancreatic lipase related protein 2 (gene/pseudogene) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118405699-118406228 Neighboring gene HSPA12A antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 10762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118441833-118442334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118442335-118442834 Neighboring gene heat shock protein family A (Hsp70) member 12A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118450610-118451348 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118453631-118454602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118501942-118502646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118502647-118503350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118526330-118526895 Neighboring gene ribosomal protein L5 pseudogene 27 Neighboring gene uncharacterized LOC105378498

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural specializations of the sperm tail. Leung MR, et al. Cell, 2023 Jun 22. PMID 37327785, Free PMC Article
    2. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
    3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
    5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of chromosome 10 open reading frame 82 (C10orf82) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sperm-associated microtubule inner protein 5
    Names
    sperm associated microtubule inner protein 5
    uncharacterized protein C10orf82

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330142.3 → NP_001317071.1  sperm-associated microtubule inner protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC016825, BC021737, BX117017, BX537582, HY204705
      Consensus CDS
      CCDS81510.1
      UniProtKB/Swiss-Prot
      B3KUM9, D3DRC3, K7EKP3, Q8WW14

    2. NM_001350930.2 → NP_001337859.1  sperm-associated microtubule inner protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC016825, AI218030, AI797771, BX106852, BX117017, BX537582, HY204705
      Consensus CDS
      CCDS81510.1
      UniProtKB/Swiss-Prot
      B3KUM9, D3DRC3, K7EKP3, Q8WW14

    3. NM_001350931.2 → NP_001337860.1  sperm-associated microtubule inner protein 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC021737, BX117017, BX537582, DB451139, HY204705
      Consensus CDS
      CCDS81510.1
      UniProtKB/Swiss-Prot
      B3KUM9, D3DRC3, K7EKP3, Q8WW14
      Related
      ENSP00000465712.1, ENST00000588184.2

    4. NM_144661.4 → NP_653262.1  sperm-associated microtubule inner protein 5 isoform 1

      See identical proteins and their annotated locations for NP_653262.1

      Status: VALIDATED

      Source sequence(s)
      BC021737
      Consensus CDS
      CCDS7596.1
      UniProtKB/Swiss-Prot
      Q8WW14
      Related
      ENSP00000358212.3, ENST00000369210.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      116662211..116670282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424663.1 → XP_047280619.1  sperm-associated microtubule inner protein 5 isoform X4

    2. XM_011539342.3 → XP_011537644.1  sperm-associated microtubule inner protein 5 isoform X2

      See identical proteins and their annotated locations for XP_011537644.1

    3. XM_011539341.2 → XP_011537643.1  sperm-associated microtubule inner protein 5 isoform X2

      See identical proteins and their annotated locations for XP_011537643.1

    4. XM_011539343.4 → XP_011537645.1  sperm-associated microtubule inner protein 5 isoform X3

    5. XM_011539340.4 → XP_011537642.1  sperm-associated microtubule inner protein 5 isoform X1

    6. XM_011539346.4 → XP_011537648.1  sperm-associated microtubule inner protein 5 isoform X5

      See identical proteins and their annotated locations for XP_011537648.1

    7. XM_011539347.4 → XP_011537649.1  sperm-associated microtubule inner protein 5 isoform X6

    8. XM_011539344.4 → XP_011537646.1  sperm-associated microtubule inner protein 5 isoform X5

      See identical proteins and their annotated locations for XP_011537646.1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791790.1 Reference GRCh38.p14 PATCHES

      Range
      73207..81278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333106.1 → XP_054189081.1  sperm-associated microtubule inner protein 5 isoform X4

    2. XM_054333104.1 → XP_054189079.1  sperm-associated microtubule inner protein 5 isoform X2

    3. XM_054333103.1 → XP_054189078.1  sperm-associated microtubule inner protein 5 isoform X2

    4. XM_054333102.1 → XP_054189077.1  sperm-associated microtubule inner protein 5 isoform X1

    5. XM_054333105.1 → XP_054189080.1  sperm-associated microtubule inner protein 5 isoform X3

    6. XM_054333107.1 → XP_054189082.1  sperm-associated microtubule inner protein 5 isoform X5

    7. XM_054333108.1 → XP_054189083.1  sperm-associated microtubule inner protein 5 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      117556531..117564614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364919.1 → XP_054220894.1  sperm-associated microtubule inner protein 5 isoform X4

    2. XM_054364917.1 → XP_054220892.1  sperm-associated microtubule inner protein 5 isoform X2

    3. XM_054364916.1 → XP_054220891.1  sperm-associated microtubule inner protein 5 isoform X2

    4. XM_054364915.1 → XP_054220890.1  sperm-associated microtubule inner protein 5 isoform X1

    5. XM_054364918.1 → XP_054220893.1  sperm-associated microtubule inner protein 5 isoform X3

    6. XM_054364921.1 → XP_054220896.1  sperm-associated microtubule inner protein 5 isoform X5

    7. XM_054364920.1 → XP_054220895.1  sperm-associated microtubule inner protein 5 isoform X5

    8. XM_054364922.1 → XP_054220897.1  sperm-associated microtubule inner protein 5 isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8WW14.3 GenPept UniProtKB/Swiss-Prot:Q8WW14

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