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    MIR3681HG MIR3681 host gene [ Homo sapiens (human) ]

    Gene ID: 100506457, updated on 22-Oct-2024

    Summary

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    Official Symbol
    MIR3681HGprovided by HGNC
    Official Full Name
    MIR3681 host geneprovided by HGNC
    Primary source
    HGNC:HGNC:52001
    See related
    Ensembl:ENSG00000224184 AllianceGenome:HGNC:52001
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See MIR3681HG in Genome Data Viewer
    Location:
    2p24.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (12007116..12578348)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (12035944..12607432)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (12147242..12718474)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:11919054-11920253 Neighboring gene lipin 1 Neighboring gene Sharpr-MPRA regulatory region 7856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15325 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11970167-11970883 Neighboring gene uncharacterized LOC105373430 Neighboring gene microRNA 548s Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15326 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15329 Neighboring gene Sharpr-MPRA regulatory region 12680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11179 Neighboring gene microRNA 4262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15332 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15333 Neighboring gene Sharpr-MPRA regulatory region 524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15334 Neighboring gene small nucleolar RNA SNORD18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15337 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:12236487-12237090 Neighboring gene uncharacterized LOC105373433 Neighboring gene ST13, Hsp70 interacting protein pseudogene 1 Neighboring gene MPRA-validated peak3592 silencer Neighboring gene MPRA-validated peak3593 silencer Neighboring gene MPRA-validated peak3594 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:12303443-12303944 Neighboring gene uncharacterized LOC105373432 Neighboring gene microRNA 3681 Neighboring gene NFE2L2 motif-containing MPRA enhancer 141 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:12537530-12538729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15338 Neighboring gene uncharacterized LOC105373431 Neighboring gene RNA, U6 small nuclear 843, pseudogene Neighboring gene uncharacterized LOC107985853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15339 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11181 Neighboring gene NANOG hESC enhancer GRCh37_chr2:12714950-12715488 Neighboring gene MPRA-validated peak3595 silencer Neighboring gene Sharpr-MPRA regulatory region 12883 Neighboring gene MPRA-validated peak3596 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:12766335-12766899 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:12804005-12804220 Neighboring gene uncharacterized LOC124905974 Neighboring gene CRISPRi-validated cis-regulatory element chr2.599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11182 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:12856972-12857611 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:12858891-12859528 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:12866409-12867608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15341 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15342 Neighboring gene microRNA 3125 Neighboring gene tribbles pseudokinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A genome-wide association study (GWAS) for bronchopulmonary dysplasia. Wang H, et al. Pediatrics, 2013 Aug. PMID 23897914, Free PMC Article
    2. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Barrett JC, et al. Nat Genet, 2009 Jun. PMID 19430480, Free PMC Article
    3. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. Wang KS, et al. Schizophr Res, 2010 Dec. PMID 20889312
    4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. Comuzzie AG, et al. PLoS One, 2012. PMID 23251661, Free PMC Article
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
    EBI GWAS Catalog
    A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.
    EBI GWAS Catalog
    Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
    EBI GWAS Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Potential readthrough

    Included gene: TRIB2

    Clone Names

    • FLJ10696, AC096559.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_110196.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC013471, AC096559, AK001558
      Related
      ENST00000412294.6

    2. NR_110197.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks four 3' exons and contains two alternate 3' terminal exons, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC012592, AC013471
      Related
      ENST00000451644.6

    3. NR_110198.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks four 3' exons and contains an alternate 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC013471, BX113352
      Related
      ENST00000450916.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      12007116..12578348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      12035944..12607432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials