U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PDGFA platelet derived growth factor subunit A [ Homo sapiens (human) ]

    Gene ID: 5154, updated on 3-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PDGFAprovided by HGNC
    Official Full Name
    platelet derived growth factor subunit Aprovided by HGNC
    Primary source
    HGNC:HGNC:8799
    See related
    Ensembl:ENSG00000197461 MIM:173430; AllianceGenome:HGNC:8799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDGF1; PDGF-A
    Summary
    This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
    Expression
    Ubiquitous expression in lung (RPKM 8.8), placenta (RPKM 8.7) and 24 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PDGFA in Genome Data Viewer
    Location:
    7p22.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (497258..520700, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (598210..621677, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (536895..560337, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC116435278 Neighboring gene uncharacterized LOC112267991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:473022-473858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:473859-474694 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:475441-476640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:485302-485962 Neighboring gene uncharacterized LOC124901566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:499317-500044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:500045-500772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:510601-511557 Neighboring gene Sharpr-MPRA regulatory region 3057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:515046-515940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:519557-520077 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:530277-531056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:531057-531836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:535084-536005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:536006-536926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:543335-544112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:549933-550440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:550441-550948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:551965-552472 Neighboring gene Sharpr-MPRA regulatory region 8552 Neighboring gene NANOG hESC enhancer GRCh37_chr7:555259-555760 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:556430-557352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:558275-559196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:561041-561962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17812 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:570324-570520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:572659-573216 Neighboring gene PDGFA divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:578299-579242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:579243-580184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:592082-592582 Neighboring gene PRKAR1B antisense RNA 2 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:611753-612521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:612522-613291 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:630646-630792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:643285-643970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25473 Neighboring gene PRKAR1B antisense RNA 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Serum and CSF PDGF-AA and FGF-2 in relapsing-remitting multiple sclerosis: a case-control study. Harirchian MH, et al. Eur J Neurol, 2012 Feb. PMID 21771201
    2. Complex patterns of intragenic polymorphism at the PDGFA locus. Bonthron DT, et al. Hum Genet, 1999 Nov. PMID 10598812
    3. Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes. Abderrahmani A, et al. Diabetes, 2018 Jul. PMID 29728363
    4. Expression of platelet-derived growth factor A-chain (PDGF-A) mRNA in lung tissue and cells. Complex regulation during remodeling. Fabisiak JP, et al. Chest, 1991 Mar. PMID 1997274
    5. Increased Expression of PDGFA Is Associated With Poor Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma. Wang K, et al. J Oral Pathol Med, 2024 Oct. PMID 39295197

    See all (194) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Increased Expression of PDGFA Is Associated With Poor Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma.
      Title: Increased Expression of PDGFA Is Associated With Poor Prognosis and Immune Infiltration in Head and Neck Squamous Cell Carcinoma.
    2. Molecular profile and peripheral markers of neurodegeneration in patients with Niemann-Pick type C: Decrease in Plasminogen Activator Inhibitor type 1 and Platelet-Derived Growth Factor type AA.
      Title: Molecular profile and peripheral markers of neurodegeneration in patients with Niemann-Pick type C: Decrease in Plasminogen Activator Inhibitor type 1 and Platelet-Derived Growth Factor type AA.
    3. PDGF-AA activates AKT and ERK signaling for testicular interstitial Leydig cell growth via primary cilia.
      Title: PDGF-AA activates AKT and ERK signaling for testicular interstitial Leydig cell growth via primary cilia.
    4. PDGFA-associated protein 1 is a novel target of c-Myc and contributes to colorectal cancer initiation and progression.
      Title: PDGFA-associated protein 1 is a novel target of c-Myc and contributes to colorectal cancer initiation and progression.
    5. PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle.
      Title: PDGF regulates guanylate cyclase expression and cGMP signaling in vascular smooth muscle.
    6. EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma.
      Title: EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma.
    7. Lyophilised Platelet-Rich Fibrin: Physical and Biological Characterisation.
      Title: Lyophilised Platelet-Rich Fibrin: Physical and Biological Characterisation.
    8. Platelet-Derived Growth Factor Predicts Vulnerable Plaque in Patients with Non-ST Elevation Acute Coronary Syndrome.
      Title: Platelet-Derived Growth Factor Predicts Vulnerable Plaque in Patients with Non-ST Elevation Acute Coronary Syndrome.
    9. High expression of PDGFA predicts poor prognosis of esophageal squamous cell carcinoma.
      Title: High expression of PDGFA predicts poor prognosis of esophageal squamous cell carcinoma.
    10. HaCaTconditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGFAA prevents the dedifferentiation of dermal papilla cells in vitro.
      Title: HaCaT‑conditioned medium supplemented with the small molecule inhibitors SB431542 and CHIR99021 and the growth factor PDGF‑AA prevents the dedifferentiation of dermal papilla cells in vitro.
    Submit: New GeneRIF Correction See all GeneRIFs (128)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

    Go to the top of the page Help

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates members of the PDGF/VEGF growth factor family (PDGFA, VEGFA,VEGFB, VEGFC) in mammary epithelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables collagen binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables platelet-derived growth factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables platelet-derived growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables platelet-derived growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables platelet-derived growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in animal organ morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell activation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell projection assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in embryonic lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in hair follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lung alveolus development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of phosphatidylinositol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of platelet activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in platelet-derived growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in platelet-derived growth factor receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in platelet-derived growth factor receptor-alpha signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of mesenchymal cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in regulation of DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in regulation of glomerular mesangial cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to wounding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in skin development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in wound healing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microvillus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
    		  
    part_of platelet-derived growth factor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    platelet-derived growth factor subunit A
    Names
    PDGF A-chain
    PDGF subunit A
    platelet-derived growth factor A-chain
    platelet-derived growth factor alpha chain
    platelet-derived growth factor alpha polypeptide

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029727.1 RefSeqGene

      Range
      4999..27587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001395363.1 → NP_001382292.1  platelet-derived growth factor subunit A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC147651
      Conserved Domains (2) summary
      smart00141
      Location:139 → 226
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:96 → 140
      PDGF_N; Platelet-derived growth factor, N terminal region

    2. NM_001395364.1 → NP_001382293.1  platelet-derived growth factor subunit A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC147651
      UniProtKB/TrEMBL
      H7BYW6
      Conserved Domains (1) summary
      smart00141
      Location:107 → 194
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

    3. NM_001395365.1 → NP_001382294.1  platelet-derived growth factor subunit A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC147651
      UniProtKB/TrEMBL
      H7BYW6
      Conserved Domains (1) summary
      smart00141
      Location:97 → 184
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

    4. NM_001395366.1 → NP_001382295.1  platelet-derived growth factor subunit A isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC147651
      Consensus CDS
      CCDS47524.1
      UniProtKB/TrEMBL
      A8K852
      Conserved Domains (2) summary
      smart00141
      Location:94 → 181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:21 → 95
      PDGF_N; Platelet-derived growth factor, N terminal region

    5. NM_002607.6 → NP_002598.4  platelet-derived growth factor subunit A isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_002598.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). The protein contains a C-terminal basic motif encoded by exon 6, the exon missing in variant 2.
      Source sequence(s)
      AC147651
      Consensus CDS
      CCDS34578.1
      UniProtKB/Swiss-Prot
      B5BU73, P04085
      UniProtKB/TrEMBL
      A8K852
      Related
      ENSP00000346508.5, ENST00000354513.9
      Conserved Domains (2) summary
      smart00141
      Location:94 → 181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:21 → 95
      PDGF_N; Platelet-derived growth factor, N terminal region

    6. NM_033023.5 → NP_148983.1  platelet-derived growth factor subunit A isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_148983.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks exon 6, compared to variant 1, and encodes the shorter isoform (2).
      Source sequence(s)
      AC147651
      Consensus CDS
      CCDS47524.1
      UniProtKB/TrEMBL
      A8K852
      Related
      ENSP00000383889.3, ENST00000402802.8
      Conserved Domains (2) summary
      smart00141
      Location:94 → 181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:21 → 95
      PDGF_N; Platelet-derived growth factor, N terminal region

    RNA

    1. NR_172526.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC147651

    2. NR_172527.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC147651

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      497258..520700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420456.1 → XP_047276412.1  platelet-derived growth factor subunit A isoform X6

    2. XM_047420455.1 → XP_047276411.1  platelet-derived growth factor subunit A isoform X4

    3. XM_011515415.2 → XP_011513717.1  platelet-derived growth factor subunit A isoform X1

      Conserved Domains (2) summary
      smart00141
      Location:139 → 226
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:101 → 140
      PDGF_N; Platelet-derived growth factor, N terminal region

    4. XM_011515418.2 → XP_011513720.1  platelet-derived growth factor subunit A isoform X3

      UniProtKB/TrEMBL
      A8K852
      Conserved Domains (2) summary
      smart00141
      Location:132 → 219
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:59 → 133
      PDGF_N; Platelet-derived growth factor, N terminal region

    5. XM_011515416.2 → XP_011513718.1  platelet-derived growth factor subunit A isoform X2

      UniProtKB/TrEMBL
      A8K852
      Conserved Domains (1) summary
      smart00141
      Location:132 → 219
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

    6. XM_047420457.1 → XP_047276413.1  platelet-derived growth factor subunit A isoform X7

      UniProtKB/Swiss-Prot
      B5BU73, P04085

    7. XM_017012289.2 → XP_016867778.1  platelet-derived growth factor subunit A isoform X5

      UniProtKB/TrEMBL
      A8K852

    8. XM_047420458.1 → XP_047276414.1  platelet-derived growth factor subunit A isoform X9

    9. XM_011515419.4 → XP_011513721.1  platelet-derived growth factor subunit A isoform X8

      UniProtKB/TrEMBL
      A8K852
      Conserved Domains (2) summary
      smart00141
      Location:93 → 180
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:21 → 94
      PDGF_N; Platelet-derived growth factor, N terminal region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      598210..621677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358366.1 → XP_054214341.1  platelet-derived growth factor subunit A isoform X6

    2. XM_054358364.1 → XP_054214339.1  platelet-derived growth factor subunit A isoform X4

    3. XM_054358361.1 → XP_054214336.1  platelet-derived growth factor subunit A isoform X1

    4. XM_054358363.1 → XP_054214338.1  platelet-derived growth factor subunit A isoform X3

    5. XM_054358362.1 → XP_054214337.1  platelet-derived growth factor subunit A isoform X2

    6. XM_054358367.1 → XP_054214342.1  platelet-derived growth factor subunit A isoform X7

      UniProtKB/Swiss-Prot
      B5BU73, P04085

    7. XM_054358365.1 → XP_054214340.1  platelet-derived growth factor subunit A isoform X5

    8. XM_054358369.1 → XP_054214344.1  platelet-derived growth factor subunit A isoform X9

    9. XM_054358368.1 → XP_054214343.1  platelet-derived growth factor subunit A isoform X8

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04085.1 GenPept UniProtKB/Swiss-Prot:P04085

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous