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    NAA35 N-alpha-acetyltransferase 35, NatC auxiliary subunit [ Homo sapiens (human) ]

    Gene ID: 60560, updated on 14-Nov-2024

    Summary

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    Official Symbol
    NAA35provided by HGNC
    Official Full Name
    N-alpha-acetyltransferase 35, NatC auxiliary subunitprovided by HGNC
    Primary source
    HGNC:HGNC:24340
    See related
    Ensembl:ENSG00000135040 MIM:619438; AllianceGenome:HGNC:24340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EGAP; MAK10; MAK10P; bA379P1.1
    Summary
    Predicted to enable transferase activity. Involved in negative regulation of apoptotic process. Located in cytosol; nucleoplasm; and plasma membrane. Part of NatC complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 7.0), colon (RPKM 6.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NAA35 in Genome Data Viewer
    Location:
    9q21.33
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (85941146..86025462)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (98091659..98175989)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (88556061..88640377)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:88513172-88514371 Neighboring gene PHB1 pseudogene 7 Neighboring gene ribosomal L1 domain-containing protein 1-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19991 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88650825-88651760 Neighboring gene golgi membrane protein 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88677599-88678515 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88679748-88680248 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:88680249-88681249 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:88693798-88694997 Neighboring gene Sharpr-MPRA regulatory region 3020 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:88713914-88714414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19994 Neighboring gene uncharacterized LOC101927623 Neighboring gene allregulin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel epithelial wound-related gene is abundantly expressed in developing rat cornea and skin. Yi XJ, et al. Curr Eye Res, 2000 May. PMID 10855038
    2. Evaluation of Salivary Exosomal Chimeric GOLM1-NAA35 RNA as a Potential Biomarker in Esophageal Carcinoma. Lin Y, et al. Clin Cancer Res, 2019 May 15. PMID 30745298
    3. Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Li Y, et al. Nat Med, 2016 Aug. PMID 27376574, Free PMC Article
    4. Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma. Zhang H, et al. Oncotarget, 2013 Nov. PMID 24243830, Free PMC Article
    5. N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Varland S, et al. Nat Commun, 2023 Oct 27. PMID 37891180, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. salivary exosomal GOLM1-NAA35 chimeric RNA (seG-NchiRNA) constitutes an effective candidate noninvasive biomarker for the convenient, reliable assessment of therapeutic response, recurrence, and early detection.
      Title: Evaluation of Salivary Exosomal Chimeric GOLM1-NAA35 RNA as a Potential Biomarker in Esophageal Carcinoma.
    2. A cytokine QTL at the NAA35-GOLM1 locus markedly modulated interleukin (IL)-6 production in response to multiple pathogens and was associated with susceptibility to candidemia.
      Title: Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi.
    3. Data demonstrate that chimera GOLM1-MAK10 encodes a secreted fusion protein. Mechanistic studies reveal that GOLM1-MAK10 is likely derived from transcription read-through/splicing rather than being generated from a fusion gene.
      Title: Aberrant chimeric RNA GOLM1-MAK10 encoding a secreted fusion protein as a molecular signature for human esophageal squamous cell carcinoma.
    4. Human Naa35 (MAK10) is an auxiliary subunit of the human NatC N-terminal acetyltransferase complex. NatC acetylates hydrophobic Met-starting N-termini, and NatC knockdown induces p53-dependent apoptosis.
      Title: Knockdown of human N alpha-terminal acetyltransferase complex C leads to p53-dependent apoptosis and aberrant human Arl8b localization.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21613, FLJ22643

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of NatC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NatC complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 35, NatC auxiliary subunit
    Names
    MAK10 homolog, amino-acid N-acetyltransferase subunit
    corneal wound healing-related protein
    embryonic growth-associated protein homolog
    protein MAK10 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001321881.2 → NP_001308810.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit

      Status: VALIDATED

      Source sequence(s)
      AK026296, AK292239, AL161447, BC117429
      Consensus CDS
      CCDS6673.1
      UniProtKB/Swiss-Prot
      Q5VZE5, Q5VZE6, Q9H631, Q9H703
      UniProtKB/TrEMBL
      A8K874
      Conserved Domains (1) summary
      pfam04112
      Location:46 → 181
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    2. NM_001321882.2 → NP_001308811.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit

      Status: VALIDATED

      Source sequence(s)
      AL161447, AL161453, AL353743
      Consensus CDS
      CCDS6673.1
      UniProtKB/Swiss-Prot
      Q5VZE5, Q5VZE6, Q9H631, Q9H703
      UniProtKB/TrEMBL
      A8K874
      Conserved Domains (1) summary
      pfam04112
      Location:46 → 181
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    3. NM_024635.4 → NP_078911.3  N-alpha-acetyltransferase 35, NatC auxiliary subunit

      See identical proteins and their annotated locations for NP_078911.3

      Status: VALIDATED

      Source sequence(s)
      AL161447, BC117427, CA945233, DB023442
      Consensus CDS
      CCDS6673.1
      UniProtKB/Swiss-Prot
      Q5VZE5, Q5VZE6, Q9H631, Q9H703
      UniProtKB/TrEMBL
      A8K874
      Related
      ENSP00000354972.5, ENST00000361671.10
      Conserved Domains (1) summary
      pfam04112
      Location:46 → 181
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      85941146..86025462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005252127.5 → XP_005252184.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

      See identical proteins and their annotated locations for XP_005252184.1

      UniProtKB/Swiss-Prot
      Q5VZE5, Q5VZE6, Q9H631, Q9H703
      UniProtKB/TrEMBL
      A8K874
      Conserved Domains (1) summary
      pfam04112
      Location:46 → 181
      Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase

    2. XM_047423710.1 → XP_047279666.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2

    3. XM_024447648.2 → XP_024303416.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X3

    4. XM_024447649.2 → XP_024303417.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      98091659..98175989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363503.1 → XP_054219478.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X1

      UniProtKB/Swiss-Prot
      Q5VZE5, Q5VZE6, Q9H631, Q9H703

    2. XM_054363504.1 → XP_054219479.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X2

    3. XM_054363505.1 → XP_054219480.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X3

    4. XM_054363506.1 → XP_054219481.1  N-alpha-acetyltransferase 35, NatC auxiliary subunit isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_021929.1: Suppressed sequence

      Description
      NM_021929.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VZE5.1 GenPept UniProtKB/Swiss-Prot:Q5VZE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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