GTF2A2 general transcription factor IIA subunit 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GTF2A2provided by HGNC
Official Full Name: general transcription factor IIA subunit 2provided by HGNC
Primary source: HGNC:HGNC:4647
See related: Ensembl:ENSG00000140307 MIM:600519; AllianceGenome:HGNC:4647
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TF2A2; TFIIA; T18745; TFIIAS; HsT18745; TFIIA-12; TFIIA-gamma
Summary: Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]
Expression: Broad expression in testis (RPKM 46.4), colon (RPKM 13.2) and 24 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 15q22.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (59638062..59657515, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (57439769..57459225, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (59930261..59949714, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that many TATA-box-containing promoters contain a TFIIA recognition element (IIARE) that activates transcription by increasing the recruitment of RNA polymerase II, TFIIA (TF2A1/TF2A2 subunits), TAF4, and P300. (TAF4 = TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1; P300 = E1A binding protein p300)
Title: A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.
transcription factor IIA may regulate the intracellular molecular state and the function of TATA-binding protein-like protein (TLP) through its property of binding to TLP
Title: Specific interaction with transcription factor IIA and localization of the mammalian TATA-binding protein-like protein (TLP/TRF2/TLF).

Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat stabilizes the interaction of TFIIA with TFIID, and TFIIA and TFIID are required to reconstitute Tat-specific and TAR-dependent activation of HIV transcription in vitro	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

WI-11900 (e-PCR)
- UniSTS:78099

STS-U14193 (e-PCR)
- UniSTS:73493

D15S1163 (e-PCR)
- UniSTS:61259

STS-N32216 (e-PCR)
- UniSTS:44992

G44724 (e-PCR)
- UniSTS:95199

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II general transcription initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II general transcription initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables TBP-class protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables TBP-class protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in RNA polymerase II preinitiation complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA polymerase II preinitiation complex assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell junction	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIA complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIA complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription factor TFIID complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: transcription initiation factor IIA subunit 2

Names: TFIIA gamma subunit; TFIIA p12 subunit; general transcription factor IIA 2; general transcription factor IIA, 2, 12kDa; transcription initiation factor IIA gamma chain

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001320929.2 → NP_001307858.1 transcription initiation factor IIA subunit 2

Status: VALIDATED

Source sequence(s)

AC092755, BX099306, HY002503, HY036972

Consensus CDS

CCDS10173.1

UniProtKB/Swiss-Prot

A8MYQ7, P52657, Q6FGB5

UniProtKB/TrEMBL

B2R506

Related

ENSP00000379373.1, ENST00000396061.5

Conserved Domains (1) summary

COG5123
Location:3 → 103

TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]
NM_001320930.2 → NP_001307859.1 transcription initiation factor IIA subunit 2

Status: VALIDATED

Source sequence(s)

AC092755, BX099306, CB156109

Consensus CDS

CCDS10173.1

UniProtKB/Swiss-Prot

A8MYQ7, P52657, Q6FGB5

UniProtKB/TrEMBL

B2R506

Related

ENSP00000379375.1, ENST00000396063.5

Conserved Domains (1) summary

COG5123
Location:3 → 103

TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]
NM_004492.3 → NP_004483.1 transcription initiation factor IIA subunit 2

See identical proteins and their annotated locations for NP_004483.1

Status: VALIDATED

Source sequence(s)

AK312015, BC000287, CV572751, DB531003

Consensus CDS

CCDS10173.1

UniProtKB/Swiss-Prot

A8MYQ7, P52657, Q6FGB5

UniProtKB/TrEMBL

B2R506

Related

ENSP00000379372.2, ENST00000396060.7

Conserved Domains (1) summary

COG5123
Location:3 → 103

TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]