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    NME2P1 NME2 pseudogene 1 [ Homo sapiens (human) ]

    Gene ID: 283458, updated on 27-Aug-2024

    Summary

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    Official Symbol
    NME2P1provided by HGNC
    Official Full Name
    NME2 pseudogene 1provided by HGNC
    Primary source
    HGNC:HGNC:31358
    See related
    AllianceGenome:HGNC:31358
    Gene type
    pseudo
    RefSeq status
    INFERRED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in regulation of apoptotic process. Located in extracellular exosome and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    12q24.23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120282218..120282856)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120269390..120270028)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120720021..120720659)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903034 Neighboring gene paxillin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4943 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120662858-120663539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7135 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120664223-120664903 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4944 Neighboring gene hESC enhancers GRCh37_chr12:120667255-120667814 and GRCh37_chr12:120667815-120668374 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:120668816-120670015 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120670055-120670614 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120671735-120672294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120676424-120677054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120682649-120683475 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7137 Neighboring gene ribosomal protein S20 pseudogene 31 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120697989-120698555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120717966-120718466 Neighboring gene hESC enhancers GRCh37_chr12:120727716-120728708 and GRCh37_chr12:120728709-120729700 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120730693-120731684 Neighboring gene RNA, U4 small nuclear 2 Neighboring gene sirtuin 4 Neighboring gene RNA, U4 small nuclear 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the human nm23-H2 promoter region and localization of the microsatellite D17S396. Seifert M, et al. Biochem Biophys Res Commun, 1995 Oct 24. PMID 7488060
    2. Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. Dooley S, et al. Hum Genet, 1994 Jan. PMID 8270257
    3. PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Lau E, et al. Cell, 2012 Feb 3. PMID 22304920, Free PMC Article
    4. Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation. Raisner R, et al. Cell Rep, 2018 Aug 14. PMID 30110629
    5. IKK-Mediated Regulation of the COP9 Signalosome via Phosphorylation of CSN5. Zhang J, et al. J Proteome Res, 2020 Mar 6. PMID 31950832, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • NME/NM23 nucleoside diphosphate kinase 2 pseudogene 1
    • non-metastatic cells 2, protein (NM23B) expressed in, pseudogene 1
    • nucleoside diphosphate kinase B-like pseudogene

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in nucleus HDA PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027861.5 

      Range
      101..739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      120282218..120282856
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      120269390..120270028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_176827.2: Suppressed sequence

      Description
      NM_176827.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.

    2. NR_001577.1: Suppressed sequence

      Description
      NR_001577.1: This RefSeq was permanently suppressed because there is insufficient evidence that this locus is transcribed.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60361.1 GenPept UniProtKB/Swiss-Prot:O60361

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.