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    GPR26 G protein-coupled receptor 26 [ Homo sapiens (human) ]

    Gene ID: 2849, updated on 26-Nov-2024

    Summary

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    Official Symbol
    GPR26provided by HGNC
    Official Full Name
    G protein-coupled receptor 26provided by HGNC
    Primary source
    HGNC:HGNC:4481
    See related
    Ensembl:ENSG00000154478 MIM:604847; AllianceGenome:HGNC:4481
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]
    Expression
    Restricted expression toward brain (RPKM 2.1) See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR26 in Genome Data Viewer
    Location:
    10q26.13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (123666355..123697399)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (124543147..124574217)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (125425871..125456915)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:124984539-124985040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125034867-125035366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2904 Neighboring gene long intergenic non-protein coding RNA 2641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4158 Neighboring gene VISTA enhancer hs578 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:125194236-125194421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125206418-125206918 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:125218162-125218857 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125218858-125219552 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125219553-125220248 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr10:125251140-125251910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125256249-125256976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125256977-125257703 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125273408-125273955 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125272859-125273407 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:125298302-125299501 Neighboring gene uncharacterized LOC105378530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125309926-125310436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125310437-125310946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125317863-125318581 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125347653-125348156 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:125366796-125367386 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125399083-125399626 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125399627-125400170 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125425617-125426155 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125426156-125426693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125425079-125425616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125430545-125431046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125443142-125443642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125443643-125444143 Neighboring gene uncharacterized LOC105378532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125488883-125489382 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125506649-125507630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125520224-125521126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125521127-125522029 Neighboring gene uncharacterized LOC105378533 Neighboring gene carboxypeptidase X, M14 family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. G protein-coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases. Mori F, et al. Neuropathology, 2016 Feb. PMID 26303144
    2. GPR26: a marker for primary glioblastoma? Carter AN, et al. Mol Cell Probes, 2008 Apr. PMID 18037267
    3. MiR-188-3p/GPR26 modulation functions as a potential regulator in manipulating glioma cell properties. Meng L, et al. Neurol Res, 2020 Mar. PMID 32024457
    4. The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas. Boulay JL, et al. Int J Oncol, 2009 Nov. PMID 19787267
    5. Tissue distribution and functional analyses of the constitutively active orphan G protein coupled receptors, GPR26 and GPR78. Jones PG, et al. Biochim Biophys Acta, 2007 Jun. PMID 17363172

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-188-3p/GPR26 modulation functions as a potential regulator in manipulating glioma cell properties.
      Title: MiR-188-3p/GPR26 modulation functions as a potential regulator in manipulating glioma cell properties.
    2. GPR26 may have a common role in the formation or degradation of intranuclear inclusions in several neurodegenerative diseases
      Title: G protein-coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    4. epigenetic silencing is a common mechanism in malignant gliomas that simultaneously inactivates MGMT and GPR26
      Title: The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas.
    5. Study has identified GPR26 to be a genetic indicator of primary glioblastoma, suggesting that it could be a suppressor of primary glioblastoma development.
      Title: GPR26: a marker for primary glioblastoma?
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051571.1 RefSeqGene

      Range
      5001..36045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_153442.4 → NP_703143.1  G-protein coupled receptor 26

      See identical proteins and their annotated locations for NP_703143.1

      Status: REVIEWED

      Source sequence(s)
      AC009987, AI076749, AJ505757, AK091093
      Consensus CDS
      CCDS7636.1
      UniProtKB/Swiss-Prot
      Q2M2E2, Q8NDV2
      Related
      ENSP00000284674.1, ENST00000284674.2
      Conserved Domains (1) summary
      cd15219
      Location:7 → 305
      7tmA_GPR26_GPR78-like; G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      123666355..123697399
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      124543147..124574217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NDV2.1 GenPept UniProtKB/Swiss-Prot:Q8NDV2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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