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    PTGER3 prostaglandin E receptor 3 [ Homo sapiens (human) ]

    Gene ID: 5733, updated on 26-Nov-2024

    Summary

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    Official Symbol
    PTGER3provided by HGNC
    Official Full Name
    prostaglandin E receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:9595
    See related
    Ensembl:ENSG00000050628 MIM:176806; AllianceGenome:HGNC:9595
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EP3; EP3e; EP3-I; EP3-II; EP3-IV; EP3-VI; PGE2-R; EP3-III; lnc003875
    Summary
    The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
    Expression
    Biased expression in endometrium (RPKM 21.7), kidney (RPKM 19.2) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PTGER3 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (70852358..71047816, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (70730386..70925810, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (71318041..71513499, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr1.6877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 990 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1197 Neighboring gene caspase 3 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:71172243-71172742 Neighboring gene long intergenic non-protein coding RNA 1788 Neighboring gene MPRA-validated peak284 silencer Neighboring gene uncharacterized LOC102724572 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:71429249-71429748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:71512913-71513496 Neighboring gene ZRANB2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1198 Neighboring gene uncharacterized LOC105378795 Neighboring gene ZRANB2 divergent transcript Neighboring gene zinc finger RANBP2-type containing 2 Neighboring gene microRNA 186

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Constitutive activity of human prostaglandin E receptor EP3 isoforms. Jin J, et al. Br J Pharmacol, 1997 May. PMID 9154343, Free PMC Article
    2. The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE(2)- and retaining PGE(1)-mediated signaling in live cells. Akasaka H, et al. Arch Biochem Biophys, 2017 Feb 15. PMID 28065721
    3. PGE(2)-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease. Maingret V, et al. Neurobiol Aging, 2017 Feb. PMID 27837675
    4. Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury. Han X, et al. J Cereb Blood Flow Metab, 2016 Jun. PMID 26661165, Free PMC Article
    5. Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2. Yang J, et al. Biochem Biophys Res Commun, 1994 Feb 15. PMID 8117308

    See all (118) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTGER3 knockdown inhibits the vulnerability of triple-negative breast cancer to ferroptosis.
      Title: PTGER3 knockdown inhibits the vulnerability of triple-negative breast cancer to ferroptosis.
    2. E prostanoid receptor-3 promotes oxidized low-density lipoprotein-induced human aortic smooth muscle cells inflammation.
      Title: E prostanoid receptor-3 promotes oxidized low-density lipoprotein-induced human aortic smooth muscle cells inflammation.
    3. Altered Prostaglandin E Receptor Subtype 3 Expression in Lacrimal Glands of Patients with Chronic Stevens-Johnson Syndrome.
      Title: Altered Prostaglandin E Receptor Subtype 3 Expression in Lacrimal Glands of Patients with Chronic Stevens-Johnson Syndrome.
    4. PGE2 -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
      Title: PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
    5. Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss.
      Title: Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss.
    6. Prostaglandin E2 EP receptors in cardiovascular disease: An update.
      Title: Prostaglandin E2 EP receptors in cardiovascular disease: An update.
    7. EP3 Is an Independent Prognostic Marker Only for Unifocal Breast Cancer Cases.
      Title: EP3 Is an Independent Prognostic Marker Only for Unifocal Breast Cancer Cases.
    8. EP3 and uPAR could represent novel therapeutic targets in the treatment of cervical cancer in advantaged stages.
      Title: Prostaglandin E2 receptor 3 (EP3) signaling promotes migration of cervical cancer via urokinase-type plasminogen activator receptor (uPAR).
    9. These results suggest that PGE2 regulates human brain endothelial cell migration via cooperation of EP2, EP3, and EP4 receptors.
      Title: PGE(2) -induced migration of human brain endothelial cell is mediated though protein kinase A in cooperation of EP receptors.
    10. Prostaglandin E2 -EP3 receptor subtype gene deletion in mother and son impairs platelet aggregation.
      Title: Prostaglandin E(2) -EP(3) receptor subtype gene deletion in mother and son impairs platelet aggregation.
    Submit: New GeneRIF Correction See all GeneRIFs (82)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables prostaglandin E receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prostaglandin E receptor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell death TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intestine smooth muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gastric acid secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of fever generation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear envelope TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    prostaglandin E2 receptor EP3 subtype
    Names
    PGE receptor, EP3 subtype
    PGE2 receptor EP3 subtype
    prostaglandin E receptor 3 (subtype EP3)
    prostaglandin receptor (PGE-2)
    prostanoid EP3 receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029509.2 RefSeqGene

      Range
      4993..82027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001126044.2 → NP_001119516.1  prostaglandin E2 receptor EP3 subtype isoform 4

      See identical proteins and their annotated locations for NP_001119516.1

      Status: REVIEWED

      Source sequence(s)
      AL031429, S69326
      Consensus CDS
      CCDS656.1
      UniProtKB/Swiss-Prot
      B0AZN4, B1AK19, B5BUP5, O00326, P43115, Q12943, Q12944, Q12945, Q147X8, Q16546, Q5CZ59, Q5CZ61, Q5CZ62, Q5CZ63, Q5CZ64
      UniProtKB/TrEMBL
      A8K3L9
      Conserved Domains (1) summary
      pfam00001
      Location:65 → 346
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. NM_198714.2 → NP_942007.1  prostaglandin E2 receptor EP3 subtype isoform 4

      See identical proteins and their annotated locations for NP_942007.1

      Status: REVIEWED

      Source sequence(s)
      AL031429, AL158087, D38298, X83861, X83863
      Consensus CDS
      CCDS656.1
      UniProtKB/Swiss-Prot
      B0AZN4, B1AK19, B5BUP5, O00326, P43115, Q12943, Q12944, Q12945, Q147X8, Q16546, Q5CZ59, Q5CZ61, Q5CZ62, Q5CZ63, Q5CZ64
      UniProtKB/TrEMBL
      A8K3L9
      Related
      ENSP00000359969.3, ENST00000370931.7
      Conserved Domains (1) summary
      pfam00001
      Location:65 → 346
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    3. NM_198715.3 → NP_942008.1  prostaglandin E2 receptor EP3 subtype isoform 5

      See identical proteins and their annotated locations for NP_942008.1

      Status: REVIEWED

      Source sequence(s)
      AL031429, D38299
      Consensus CDS
      CCDS658.1
      UniProtKB/TrEMBL
      Q6TTN3
      Related
      ENSP00000359962.3, ENST00000370924.5
      Conserved Domains (1) summary
      cd15146
      Location:49 → 358
      7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_198716.2 → NP_942009.1  prostaglandin E2 receptor EP3 subtype isoform 6

      See identical proteins and their annotated locations for NP_942009.1

      Status: REVIEWED

      Source sequence(s)
      AL031429, AL158087, BC024229, X83861, X83863
      Consensus CDS
      CCDS652.1
      UniProtKB/TrEMBL
      Q6TTN3
      Related
      ENSP00000418073.1, ENST00000460330.5
      Conserved Domains (1) summary
      cd15146
      Location:49 → 358
      7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. NM_198717.2 → NP_942010.1  prostaglandin E2 receptor EP3 subtype isoform 7

      See identical proteins and their annotated locations for NP_942010.1

      Status: REVIEWED

      Source sequence(s)
      AL031429, AL158087, D38301, X83861, X83863
      Consensus CDS
      CCDS44160.1
      UniProtKB/TrEMBL
      Q6TTN3
      Related
      ENSP00000486617.1, ENST00000628037.2
      Conserved Domains (1) summary
      cd15146
      Location:49 → 358
      7tmA_PGE2_EP3; prostaglandin E2 receptor EP3 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. NM_198718.2 → NP_942011.1  prostaglandin E2 receptor EP3 subtype isoform 8

      See identical proteins and their annotated locations for NP_942011.1

      Status: REVIEWED

      Source sequence(s)
      AL031429, D86097, X83862
      Consensus CDS
      CCDS655.1
      UniProtKB/TrEMBL
      Q6TTN3
      Related
      ENSP00000349003.4, ENST00000356595.8
      Conserved Domains (1) summary
      pfam00001
      Location:65 → 346
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    7. NM_198719.2 → NP_942012.1  prostaglandin E2 receptor EP3 subtype isoform 4

      See identical proteins and their annotated locations for NP_942012.1

      Status: REVIEWED

      Source sequence(s)
      AI273491, AL031429, D38297
      Consensus CDS
      CCDS657.1
      UniProtKB/Swiss-Prot
      B0AZN4, B1AK19, B5BUP5, O00326, P43115, Q12943, Q12944, Q12945, Q147X8, Q16546, Q5CZ59, Q5CZ61, Q5CZ62, Q5CZ63, Q5CZ64
      UniProtKB/TrEMBL
      A8K3L9
      Related
      ENSP00000302313.5, ENST00000306666.10
      Conserved Domains (1) summary
      pfam00001
      Location:65 → 346
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RNA

    1. NR_028292.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL031429, AL158087, D86097
      Related
      ENST00000361210.6

    2. NR_028293.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL031429, AL158087, D86098
      Related
      ENST00000479353.5

    3. NR_028294.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL031429, AL158087, D86097, X83863
      Related
      ENST00000497146.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      70852358..71047816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011541810.4 → XP_011540112.1  prostaglandin E2 receptor EP3 subtype isoform X1

      UniProtKB/TrEMBL
      A8K3L9
      Conserved Domains (1) summary
      pfam00001
      Location:65 → 346
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RNA

    1. XR_946714.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      70730386..70925810 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337808.1 → XP_054193783.1  prostaglandin E2 receptor EP3 subtype isoform X1

    RNA

    1. XR_008486118.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_000957.2: Suppressed sequence

      Description
      NM_000957.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_198712.2: Suppressed sequence

      Description
      NM_198712.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    3. NM_198713.1: Suppressed sequence

      Description
      NM_198713.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    4. NM_198720.1: Suppressed sequence

      Description
      NM_198720.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43115.1 GenPept UniProtKB/Swiss-Prot:P43115

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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