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    ZDHHC11 zinc finger DHHC-type containing 11 [ Homo sapiens (human) ]

    Gene ID: 79844, updated on 26-Nov-2024

    Summary

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    Official Symbol
    ZDHHC11provided by HGNC
    Official Full Name
    zinc finger DHHC-type containing 11provided by HGNC
    Primary source
    HGNC:HGNC:19158
    See related
    Ensembl:ENSG00000188818 AllianceGenome:HGNC:19158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF399
    Summary
    Enables signaling adaptor activity. Involved in antiviral innate immune response and positive regulation of defense response to virus by host. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung (RPKM 2.8), duodenum (RPKM 2.5) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZDHHC11 in Genome Data Viewer
    Location:
    5p15.33
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (795605..860563, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (701646..766615, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (795720..851101, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene tubulin polymerization promoting protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15876 Neighboring gene uncharacterized LOC101929898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:694389-695267 Neighboring gene NANOG hESC enhancer GRCh37_chr5:708729-709282 Neighboring gene zinc finger DHHC-type containing 11B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:727349-727849 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:752062-752252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:753615-754114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22301 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:758511-759354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:759355-760198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:771879-772522 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_86882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:782879-783538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:785123-785861 Neighboring gene bromodomain containing 9 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:794321-795181 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:811555-811724 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:827809-828355 Neighboring gene signal peptidase complex subunit 2 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:849793-850444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:850445-851094 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:892285-892917 Neighboring gene bromodomain containing 9 Neighboring gene Sharpr-MPRA regulatory region 1606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:916909-917478 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:918895-919438 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:919439-919982 Neighboring gene thyroid hormone receptor interactor 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Gain of 5p15.33 is associated with progression of bladder cancer. Yamamoto Y, et al. Oncology, 2007. PMID 18025801
    2. Circular ZDHHC11 supports Burkitt lymphoma growth independent of its miR-150 binding capacity. Liu Y, et al. Sci Rep, 2024 Apr 16. PMID 38627588, Free PMC Article
    3. ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma. Dzikiewicz-Krawczyk A, et al. Leukemia, 2017 Jun. PMID 28331227
    4. ZDHHC11 Positively Regulates NF-κB Activation by Enhancing TRAF6 Oligomerization. Liu E, et al. Front Cell Dev Biol, 2021. PMID 34490261, Free PMC Article
    5. ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association. Liu Y, et al. Cell Mol Immunol, 2018 Oct. PMID 29429998, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular ZDHHC11 supports Burkitt lymphoma growth independent of its miR-150 binding capacity.
      Title: Circular ZDHHC11 supports Burkitt lymphoma growth independent of its miR-150 binding capacity.
    2. First, MYC downregulates miR-150 to unleash MYB from the miR-150-mediated repression. Second, MYC induces ZDHHC11 and ZDHHC11B that further ensures the maintenance of high MYB levels
      Title: ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.
    3. ZDHHC11 and ZDHHC11B are novel targets of miR-150 with a key role in maintaining elevated levels of the MYB oncogene required for the high proliferation rate of Burkitt lymphoma cells.
      Title: ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.
    4. In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
      Title: In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. data suggest that gain of 5p15.33 (TPPP and ZDHHC11) may become a potential biomarker identifying high-risk patients with disease progression in bladder cancer.
      Title: Gain of 5p15.33 is associated with progression of bladder cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antiviral innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidyl-L-cysteine S-palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of defense response to virus by host IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC11
    Names
    DHHC-11
    probable palmitoyltransferase ZDHHC11
    zinc finger DHHC domain-containing protein 11
    zinc finger protein 399
    zinc finger, DHHC domain containing 11
    NP_001380421.1
    NP_079062.1
    XP_024301977.1
    XP_024301978.1
    XP_024301980.1
    XP_024301981.1
    XP_024301982.1
    XP_024301983.1
    XP_024301984.1
    XP_024301985.1
    XP_024301986.1
    XP_047273702.1
    XP_047273703.1
    XP_047273704.1
    XP_047273705.1
    XP_047273706.1
    XP_047273707.1
    XP_047273708.1
    XP_047273709.1
    XP_047273710.1
    XP_047273711.1
    XP_047273712.1
    XP_047273713.1
    XP_047273714.1
    XP_047273715.1
    XP_047273716.1
    XP_047273717.1
    XP_047273718.1
    XP_054209475.1
    XP_054209476.1
    XP_054209477.1
    XP_054209478.1
    XP_054209479.1
    XP_054209480.1
    XP_054209481.1
    XP_054209482.1
    XP_054209483.1
    XP_054209484.1
    XP_054209485.1
    XP_054209486.1
    XP_054209487.1
    XP_054209488.1
    XP_054209489.1
    XP_054209490.1
    XP_054209491.1
    XP_054209492.1
    XP_054209493.1
    XP_054209494.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393492.1 → NP_001380421.1  palmitoyltransferase ZDHHC11 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC010427, AC026740, AC122719
      Conserved Domains (1) summary
      pfam01529
      Location:193 → 330
      DHHC; DHHC palmitoyltransferase

    2. NM_024786.3 → NP_079062.1  palmitoyltransferase ZDHHC11 isoform 2

      See identical proteins and their annotated locations for NP_079062.1

      Status: VALIDATED

      Source sequence(s)
      AC010427, AC026740, AC122719
      Consensus CDS
      CCDS3857.1
      UniProtKB/Swiss-Prot
      Q6UWR9, Q9H8X9
      Related
      ENSP00000283441.8, ENST00000283441.13
      Conserved Domains (1) summary
      pfam01529
      Location:120 → 275
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      795605..860563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417747.1 → XP_047273703.1  palmitoyltransferase ZDHHC11 isoform X1

    2. XM_047417746.1 → XP_047273702.1  palmitoyltransferase ZDHHC11 isoform X1

    3. XM_024446212.2 → XP_024301980.1  palmitoyltransferase ZDHHC11 isoform X5

      UniProtKB/Swiss-Prot
      Q6UWR9, Q9H8X9
      Conserved Domains (1) summary
      pfam01529
      Location:120 → 275
      zf-DHHC; DHHC palmitoyltransferase

    4. XM_047417749.1 → XP_047273705.1  palmitoyltransferase ZDHHC11 isoform X4

    5. XM_024446210.2 → XP_024301978.1  palmitoyltransferase ZDHHC11 isoform X3

      Conserved Domains (1) summary
      pfam01529
      Location:193 → 330
      DHHC; DHHC palmitoyltransferase

    6. XM_024446209.2 → XP_024301977.1  palmitoyltransferase ZDHHC11 isoform X1

      Conserved Domains (1) summary
      pfam01529
      Location:193 → 316
      zf-DHHC; DHHC palmitoyltransferase

    7. XM_047417762.1 → XP_047273718.1  palmitoyltransferase ZDHHC11 isoform X21

    8. XM_047417761.1 → XP_047273717.1  palmitoyltransferase ZDHHC11 isoform X21

    9. XM_047417758.1 → XP_047273714.1  palmitoyltransferase ZDHHC11 isoform X20

    10. XM_047417760.1 → XP_047273716.1  palmitoyltransferase ZDHHC11 isoform X22

    11. XM_047417759.1 → XP_047273715.1  palmitoyltransferase ZDHHC11 isoform X21

      Related
      ENST00000503758.6

    12. XM_047417748.1 → XP_047273704.1  palmitoyltransferase ZDHHC11 isoform X2

    13. XM_047417754.1 → XP_047273710.1  palmitoyltransferase ZDHHC11 isoform X12

    14. XM_047417752.1 → XP_047273708.1  palmitoyltransferase ZDHHC11 isoform X9

    15. XM_047417755.1 → XP_047273711.1  palmitoyltransferase ZDHHC11 isoform X15

    16. XM_047417753.1 → XP_047273709.1  palmitoyltransferase ZDHHC11 isoform X11

    17. XM_047417751.1 → XP_047273707.1  palmitoyltransferase ZDHHC11 isoform X7

    18. XM_047417756.1 → XP_047273712.1  palmitoyltransferase ZDHHC11 isoform X17

    19. XM_024446214.2 → XP_024301982.1  palmitoyltransferase ZDHHC11 isoform X10

      Conserved Domains (1) summary
      pfam01529
      Location:193 → 263
      zf-DHHC; DHHC palmitoyltransferase

    20. XM_047417750.1 → XP_047273706.1  palmitoyltransferase ZDHHC11 isoform X6

    21. XM_024446216.2 → XP_024301984.1  palmitoyltransferase ZDHHC11 isoform X14

      Conserved Domains (1) summary
      pfam01529
      Location:193 → 261
      zf-DHHC; DHHC palmitoyltransferase

    22. XM_024446213.2 → XP_024301981.1  palmitoyltransferase ZDHHC11 isoform X8

      Conserved Domains (1) summary
      pfam01529
      Location:193 → 261
      zf-DHHC; DHHC palmitoyltransferase

    23. XM_047417757.1 → XP_047273713.1  palmitoyltransferase ZDHHC11 isoform X19

    24. XM_024446215.2 → XP_024301983.1  palmitoyltransferase ZDHHC11 isoform X13

      Conserved Domains (1) summary
      pfam01529
      Location:193 → 254
      zf-DHHC; DHHC palmitoyltransferase

    25. XM_024446217.2 → XP_024301985.1  palmitoyltransferase ZDHHC11 isoform X16

      Conserved Domains (1) summary
      cl19890
      Location:193 → 245
      zf-DHHC; DHHC palmitoyltransferase

    26. XM_024446218.2 → XP_024301986.1  palmitoyltransferase ZDHHC11 isoform X18

      Conserved Domains (1) summary
      cl19890
      Location:193 → 245
      zf-DHHC; DHHC palmitoyltransferase

    RNA

    1. XR_007058638.1 RNA Sequence

    2. XR_007058637.1 RNA Sequence

    3. XR_007058640.1 RNA Sequence

    4. XR_007058639.1 RNA Sequence

    5. XR_007058636.1 RNA Sequence

    6. XR_007058641.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      701646..766615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353502.1 → XP_054209477.1  palmitoyltransferase ZDHHC11 isoform X1

    2. XM_054353501.1 → XP_054209476.1  palmitoyltransferase ZDHHC11 isoform X1

    3. XM_054353506.1 → XP_054209481.1  palmitoyltransferase ZDHHC11 isoform X5

      UniProtKB/Swiss-Prot
      Q6UWR9, Q9H8X9

    4. XM_054353505.1 → XP_054209480.1  palmitoyltransferase ZDHHC11 isoform X4

    5. XM_054353504.1 → XP_054209479.1  palmitoyltransferase ZDHHC11 isoform X3

    6. XM_054353500.1 → XP_054209475.1  palmitoyltransferase ZDHHC11 isoform X1

    7. XM_054353512.1 → XP_054209487.1  palmitoyltransferase ZDHHC11 isoform X23

    8. XM_054353519.1 → XP_054209494.1  palmitoyltransferase ZDHHC11 isoform X21

    9. XM_054353518.1 → XP_054209493.1  palmitoyltransferase ZDHHC11 isoform X21

    10. XM_054353516.1 → XP_054209491.1  palmitoyltransferase ZDHHC11 isoform X20

    11. XM_054353517.1 → XP_054209492.1  palmitoyltransferase ZDHHC11 isoform X22

    12. XM_054353503.1 → XP_054209478.1  palmitoyltransferase ZDHHC11 isoform X2

    13. XM_054353508.1 → XP_054209483.1  palmitoyltransferase ZDHHC11 isoform X12

    14. XM_054353511.1 → XP_054209486.1  palmitoyltransferase ZDHHC11 isoform X15

    15. XM_054353507.1 → XP_054209482.1  palmitoyltransferase ZDHHC11 isoform X6

    16. XM_054353510.1 → XP_054209485.1  palmitoyltransferase ZDHHC11 isoform X14

    17. XM_054353515.1 → XP_054209490.1  palmitoyltransferase ZDHHC11 isoform X19

    18. XM_054353509.1 → XP_054209484.1  palmitoyltransferase ZDHHC11 isoform X13

    19. XM_054353513.1 → XP_054209488.1  palmitoyltransferase ZDHHC11 isoform X16

    20. XM_054353514.1 → XP_054209489.1  palmitoyltransferase ZDHHC11 isoform X18

    RNA

    1. XR_008487166.1 RNA Sequence

    2. XR_008487165.1 RNA Sequence

    3. XR_008487167.1 RNA Sequence

    4. XR_008487164.1 RNA Sequence

    5. XR_008487169.1 RNA Sequence

    6. XR_008487168.1 RNA Sequence

    7. XR_008487171.1 RNA Sequence

    8. XR_008487173.1 RNA Sequence

    9. XR_008487172.1 RNA Sequence

    10. XR_008487170.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H8X9.1 GenPept UniProtKB/Swiss-Prot:Q9H8X9

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