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    RGS12 regulator of G protein signaling 12 [ Homo sapiens (human) ]

    Gene ID: 6002, updated on 26-Nov-2024

    Summary

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    Official Symbol
    RGS12provided by HGNC
    Official Full Name
    regulator of G protein signaling 12provided by HGNC
    Primary source
    HGNC:HGNC:9994
    See related
    Ensembl:ENSG00000159788 MIM:602512; AllianceGenome:HGNC:9994
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in skin (RPKM 3.7), brain (RPKM 3.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RGS12 in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (3285891..3439913)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (3284640..3439697)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (3287618..3441640)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21218 Neighboring gene RNA, U7 small nuclear 33 pseudogene Neighboring gene huntingtin Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3137138-3137317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15201 Neighboring gene Sharpr-MPRA regulatory region 10599 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3215178-3215678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3215679-3216179 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3239294-3239953 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:3239954-3240612 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3248264-3248439 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3252404-3253300 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3271939-3272476 Neighboring gene Myb/SANT DNA binding domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15203 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3295537-3296122 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3296907-3297102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3306185-3306834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3310051-3310769 Neighboring gene X antigen family member 3 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3319084-3319638 Neighboring gene ribosomal protein L7a pseudogene 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3374529-3375457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3411075-3411982 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:3417810-3419009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3422145-3422646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3425913-3426412 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3434795-3435296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3435297-3435796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3436172-3437070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3437071-3437969 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3438515-3439015 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15205 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3450782-3451585 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3463811-3464658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3467576-3468185 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3469405-3470012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:3474943-3475654 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:3476364-3476557 Neighboring gene vegetative cell wall protein gp1-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3481667-3482258 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:3482478-3483445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:3483446-3484412 Neighboring gene HGF activator Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:3486115-3487314 Neighboring gene docking protein 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of regulators of G-protein signaling family members and characterization of binding specificity of RGS12 PDZ domain. Snow BE, et al. Methods Enzymol, 2002. PMID 11771424
    2. Use of representational difference analysis and cDNA arrays for transcriptional profiling of tumor tissue. Frohme M, et al. Ann N Y Acad Sci, 2000 Jun. PMID 10911908
    3. RGS12 Represses Oral Cancer via the Phosphorylation and SUMOylation of PTEN. Fu C, et al. J Dent Res, 2021 May. PMID 33198557, Free PMC Article
    4. RGS12 Drives Macrophage Activation and Osteoclastogenesis in Periodontitis. Yuan G, et al. J Dent Res, 2022 Apr. PMID 34796776, Free PMC Article
    5. RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment. Yuan G, et al. Cancer Commun (Lond), 2022 Jan. PMID 34931491, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct and overlapping RGS14 and RGS12 actions regulate NPT2A-mediated phosphate transport.
      Title: Distinct and overlapping RGS14 and RGS12 actions regulate NPT2A-mediated phosphate transport.
    2. RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling.
      Title: RGS12 represses oral squamous cell carcinoma by driving M1 polarization of tumor-associated macrophages via controlling ciliary MYCBP2/KIF2A signaling.
    3. RGS12 Drives Macrophage Activation and Osteoclastogenesis in Periodontitis.
      Title: RGS12 Drives Macrophage Activation and Osteoclastogenesis in Periodontitis.
    4. RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment.
      Title: RGS12 inhibits the progression and metastasis of multiple myeloma by driving M1 macrophage polarization and activation in the bone marrow microenvironment.
    5. RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling.
      Title: RGS12 is a novel tumor suppressor in osteosarcoma that inhibits YAP-TEAD1-Ezrin signaling.
    6. RGS12 Represses Oral Cancer via the Phosphorylation and SUMOylation of PTEN.
      Title: RGS12 Represses Oral Cancer via the Phosphorylation and SUMOylation of PTEN.
    7. Findings identify RGS12 as a candidate tumor-suppressor gene in AA prostate cancer, which acts by decreasing expression of AKT and MNX1, establishing a novel oncogenic axis in this disparate disease setting.
      Title: RGS12 Is a Novel Tumor-Suppressor Gene in African American Prostate Cancer That Represses AKT and MNX1 Expression.
    8. Data support the notion that the Galpha, but not Gbetagamma, arm of the Gi/o signalling is involved in TRPC4 activation and unveil new roles for RGS and RGS12 in fine-tuning TRPC4 activities.
      Title: Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
    10. RGS12 is essential for the terminal differentiation of osteoclasts induced by RANKL.
      Title: RGS12 is essential for RANKL-evoked signaling for terminal differentiation of osteoclasts in vitro.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		  
    enables GTPase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 12
    Names
    regulator of G-protein signalling 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029903.2 RefSeqGene

      Range
      12132..159024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001394154.1 → NP_001381083.1  regulator of G-protein signaling 12 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      Consensus CDS
      CCDS3366.1
      UniProtKB/Swiss-Prot
      B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
      Related
      ENSP00000338509.4, ENST00000336727.8
      Conserved Domains (9) summary
      cd08742
      Location:716 → 830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:1188 → 1209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:20 → 96
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228 → 359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:962 → 1031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:1106 → 1180
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:1239 → 1376
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836 → 949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:1032 → 1104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. NM_001394155.1 → NP_001381084.1  regulator of G-protein signaling 12 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      Consensus CDS
      CCDS3366.1
      UniProtKB/Swiss-Prot
      B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
      Conserved Domains (9) summary
      cd08742
      Location:716 → 830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:1188 → 1209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:20 → 96
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228 → 359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:962 → 1031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:1106 → 1180
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:1239 → 1376
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836 → 949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:1032 → 1104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. NM_001394156.1 → NP_001381085.1  regulator of G-protein signaling 12 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      Consensus CDS
      CCDS3367.1
      Related
      ENSP00000372238.3, ENST00000382788.7
      Conserved Domains (9) summary
      cd08742
      Location:716 → 830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:1188 → 1209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:20 → 96
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228 → 359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:962 → 1031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:1106 → 1180
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:1239 → 1376
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836 → 949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:1032 → 1104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. NM_001394157.1 → NP_001381086.1  regulator of G-protein signaling 12 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      UniProtKB/TrEMBL
      Q56A82
      Conserved Domains (5) summary
      cd08742
      Location:716 → 830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      cd00992
      Location:20 → 96
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228 → 359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:962 → 1031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      cl28922
      Location:1032 → 1104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    5. NM_001394158.1 → NP_001381087.1  regulator of G-protein signaling 12 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      UniProtKB/TrEMBL
      Q56A82
      Conserved Domains (7) summary
      cd08742
      Location:716 → 830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      cd00992
      Location:20 → 96
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228 → 359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:962 → 1031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:1106 → 1137
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16613
      Location:836 → 949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:1032 → 1104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    6. NM_001394159.1 → NP_001381088.1  regulator of G-protein signaling 12 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL645949
      Conserved Domains (4) summary
      PHA03247
      Location:452 → 814
      PHA03247; large tegument protein UL36; Provisional
      cd00992
      Location:20 → 96
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228 → 359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd21577
      Location:738 → 824
      KLF3_N; N-terminal domain of Kruppel-like factor 3

    7. NM_001394161.1 → NP_001381090.1  regulator of G-protein signaling 12 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      UniProtKB/TrEMBL
      Q506M0
      Conserved Domains (7) summary
      smart00390
      Location:387 → 408
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd17136
      Location:161 → 230
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:305 → 379
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:438 → 575
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:35 → 148
      RGS12_us1; Unstructured region of RGS12
      cl02565
      Location:1 → 29
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl28922
      Location:231 → 303
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    8. NM_001394162.1 → NP_001381091.1  regulator of G-protein signaling 12 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      UniProtKB/TrEMBL
      Q506M0
      Conserved Domains (7) summary
      smart00390
      Location:387 → 408
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd17136
      Location:161 → 230
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:305 → 379
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:438 → 575
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:35 → 148
      RGS12_us1; Unstructured region of RGS12
      cl02565
      Location:1 → 29
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl28922
      Location:231 → 303
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    9. NM_001394163.1 → NP_001381092.1  regulator of G-protein signaling 12 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      UniProtKB/TrEMBL
      Q506M0
      Conserved Domains (7) summary
      smart00390
      Location:387 → 408
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd17136
      Location:161 → 230
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:305 → 379
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:438 → 575
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:35 → 148
      RGS12_us1; Unstructured region of RGS12
      cl02565
      Location:1 → 29
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl28922
      Location:231 → 303
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    10. NM_002926.5 → NP_002917.1  regulator of G-protein signaling 12 isoform 2

      See identical proteins and their annotated locations for NP_002917.1

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      Consensus CDS
      CCDS3367.1
      UniProtKB/Swiss-Prot
      O14924
      Conserved Domains (9) summary
      cd08742
      Location:716 → 830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:1188 → 1209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:20 → 96
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228 → 359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:962 → 1031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:1106 → 1180
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:1239 → 1376
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836 → 949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:1032 → 1104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    11. NM_198227.2 → NP_937870.1  regulator of G-protein signaling 12 isoform 3

      See identical proteins and their annotated locations for NP_937870.1

      Status: REVIEWED

      Source sequence(s)
      AF030109, AF030112, BM984992, CB242608
      Consensus CDS
      CCDS3368.1
      UniProtKB/TrEMBL
      Q506M0
      Related
      ENSP00000342133.4, ENST00000338806.4
      Conserved Domains (7) summary
      smart00455
      Location:387 → 456
      RBD; Raf-like Ras-binding domain
      cd01817
      Location:315 → 387
      RGS12_RBD; Ubiquitin domain of RGS12 and RGS14
      cd08742
      Location:68 → 182
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      pfam02188
      Location:540 → 561
      GoLoco; GoLoco motif
      pfam16611
      Location:458 → 528
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:606 → 726
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:188 → 285
      RGS12_us1; Unstructured region of RGS12

    12. NM_198229.3 → NP_937872.1  regulator of G-protein signaling 12 isoform 1

      See identical proteins and their annotated locations for NP_937872.1

      Status: REVIEWED

      Source sequence(s)
      AL590235, AL645949
      Consensus CDS
      CCDS3366.1
      UniProtKB/Swiss-Prot
      B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
      Related
      ENSP00000339381.5, ENST00000344733.9
      Conserved Domains (9) summary
      cd08742
      Location:716 → 830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:1188 → 1209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:20 → 96
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228 → 359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:962 → 1031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:1106 → 1180
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:1239 → 1376
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836 → 949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:1032 → 1104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      3285891..3439913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513543.3 → XP_011511845.1  regulator of G-protein signaling 12 isoform X5

      See identical proteins and their annotated locations for XP_011511845.1

      UniProtKB/TrEMBL
      Q506M0
      Conserved Domains (7) summary
      smart00390
      Location:387 → 408
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd17136
      Location:161 → 230
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:305 → 379
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:438 → 575
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:35 → 148
      RGS12_us1; Unstructured region of RGS12
      cl02565
      Location:1 → 29
      RGS; Regulator of G protein signaling (RGS) domain superfamily
      cl28922
      Location:231 → 303
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_047416060.1 → XP_047272016.1  regulator of G-protein signaling 12 isoform X7

    3. XM_017008529.3 → XP_016864018.1  regulator of G-protein signaling 12 isoform X1

      UniProtKB/Swiss-Prot
      B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95
      Conserved Domains (9) summary
      cd08742
      Location:716 → 830
      RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein
      smart00390
      Location:1188 → 1209
      GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
      cd00992
      Location:20 → 96
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13162
      Location:228 → 359
      PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold
      cd17136
      Location:962 → 1031
      RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)
      pfam16611
      Location:1106 → 1180
      RGS12_us2; Unstructured region between RBD and GoLoco
      pfam16612
      Location:1239 → 1376
      RGS12_usC; C-terminal unstructured region of RGS12
      pfam16613
      Location:836 → 949
      RGS12_us1; Unstructured region of RGS12
      cl28922
      Location:1032 → 1104
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. XM_047416055.1 → XP_047272011.1  regulator of G-protein signaling 12 isoform X2

    5. XM_047416056.1 → XP_047272012.1  regulator of G-protein signaling 12 isoform X3

    6. XM_047416057.1 → XP_047272013.1  regulator of G-protein signaling 12 isoform X4

    7. XM_017008534.2 → XP_016864023.1  regulator of G-protein signaling 12 isoform X6

    8. XM_047416058.1 → XP_047272014.1  regulator of G-protein signaling 12 isoform X5

    9. XM_047416059.1 → XP_047272015.1  regulator of G-protein signaling 12 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      3284640..3439697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350686.1 → XP_054206661.1  regulator of G-protein signaling 12 isoform X5

    2. XM_054350688.1 → XP_054206663.1  regulator of G-protein signaling 12 isoform X7

    3. XM_054350682.1 → XP_054206657.1  regulator of G-protein signaling 12 isoform X1

      UniProtKB/Swiss-Prot
      B1AQ30, B1AQ31, B1AQ32, B7Z764, E7EMN9, O14922, O14923, O14924, O43510, O75338, Q147X0, Q8WX95

    4. XM_054350683.1 → XP_054206658.1  regulator of G-protein signaling 12 isoform X2

    5. XM_054350685.1 → XP_054206660.1  regulator of G-protein signaling 12 isoform X3

    6. XM_054350684.1 → XP_054206659.1  regulator of G-protein signaling 12 isoform X8

    7. XM_054350687.1 → XP_054206662.1  regulator of G-protein signaling 12 isoform X6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198230.1: Suppressed sequence

      Description
      NM_198230.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_198430.1: Suppressed sequence

      Description
      NM_198430.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    3. NM_198432.1: Suppressed sequence

      Description
      NM_198432.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    4. NM_198587.1: Suppressed sequence

      Description
      NM_198587.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14924.1 GenPept UniProtKB/Swiss-Prot:O14924

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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