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    DENND1A DENN domain containing 1A [ Homo sapiens (human) ]

    Gene ID: 57706, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DENND1Aprovided by HGNC
    Official Full Name
    DENN domain containing 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:29324
    See related
    Ensembl:ENSG00000119522 MIM:613633; AllianceGenome:HGNC:29324
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FAM31A; KIAA1608
    Summary
    Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1A, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery (Marat and McPherson, 2010 [PubMed 20154091]).[supplied by OMIM, Nov 2010]
    Expression
    Ubiquitous expression in spleen (RPKM 4.6), kidney (RPKM 4.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DENND1A in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (123379658..123930126, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (135577391..136128012, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (126141937..126692405, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28935 Neighboring gene uncharacterized LOC105376265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126088537-126089038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126089039-126089538 Neighboring gene uncharacterized LOC124902266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28938 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28939 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126111505-126112006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126112007-126112506 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126116439-126116938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126120157-126120824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126124971-126125833 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126128307-126128870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126130279-126130928 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126138602-126139219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126137983-126138601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126141215-126141716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126141717-126142216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28941 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:126149353-126149548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126160204-126160704 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126164885-126165506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126181680-126182180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126182181-126182681 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126185399-126186000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28942 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:126188501-126188713 Neighboring gene crumbs cell polarity complex component 2 Neighboring gene microRNA 601 Neighboring gene Sharpr-MPRA regulatory region 10302 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126244597-126245462 Neighboring gene microRNA 7150 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:126323227-126323788 Neighboring gene uncharacterized LOC105376266 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126417147-126417647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28945 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28947 Neighboring gene Sharpr-MPRA regulatory region 1336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28948 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28950 Neighboring gene VISTA enhancer hs314 Neighboring gene uncharacterized LOC124902336 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:126625148-126625690 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:126625691-126626232 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:126656962-126657562 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class F pseudogene 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:126665592-126666092 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:126666093-126666593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:126691277-126691962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126770394-126771104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126769682-126770393 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:126767105-126767862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126763235-126763735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20253 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126760357-126761111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28956 Neighboring gene uncharacterized LOC105376267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126755411-126755911 Neighboring gene LHX2 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genetic alterations within the DENND1A gene in patients with polycystic ovary syndrome (PCOS). Eriksen MB, et al. PLoS One, 2013. PMID 24086769, Free PMC Article
    2. Overexpression of a DENND1A isoform produces a polycystic ovary syndrome theca phenotype. McAllister JM, et al. Proc Natl Acad Sci U S A, 2014 Apr 15. PMID 24706793, Free PMC Article
    3. DENND1A gene variants in Bahraini Arab women with polycystic ovary syndrome. Gammoh E, et al. Gene, 2015 Apr 10. PMID 25626177
    4. Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry. Welt CK, et al. J Clin Endocrinol Metab, 2012 Jul. PMID 22547425, Free PMC Article
    5. A Multi-center Genome-wide Association Study of Cervical Dystonia. Sun YV, et al. Mov Disord, 2021 Dec. PMID 34320236, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unraveling the Genetic Associations of DENND1A (rs9696009) and ERBB4 (rs2178575) with Infertile Polycystic Ovary Syndrome Females in Pakistan.
      Title: Unraveling the Genetic Associations of DENND1A (rs9696009) and ERBB4 (rs2178575) with Infertile Polycystic Ovary Syndrome Females in Pakistan.
    2. Association of FSHR and DENND1A polymorphisms with polycystic ovary syndrome: a meta-analysis.
      Title: Association of FSHR and DENND1A polymorphisms with polycystic ovary syndrome: a meta-analysis.
    3. A Multi-center Genome-wide Association Study of Cervical Dystonia.
      Title: A Multi-center Genome-wide Association Study of Cervical Dystonia.
    4. The tagging SNPs rs2479106 and rs2468819 in the DENND1A gene are associated with polycystic ovary syndrome (PCOS) in the Chinese population, whereas rs2670139, rs2536951 and rs2479102 are not correlated with PCOS in the same population
      Title: Association analysis between the tag single nucleotide polymorphisms of DENND1A and the risk of polycystic ovary syndrome in Chinese Han women.
    5. Genetic variants of PCOS (rs13405728 in LHCGR gene; rs13429458 in THADA gene and rs2479106 in DENND1A gene) may not be involved in the development of preeclampsia in Han Chinese women.
      Title: Association study between variants in LHCGR DENND1A and THADA with preeclampsia risk in Han Chinese populations.
    6. decreased miR-130b-3p expression in PCOS theca cells, which was correlated with increased DENND1A.V2, cytochrome P450 17alpha-hydroxylase (CYP17A1) mRNA and androgen biosynthesis.
      Title: miRNA Profiling Reveals miRNA-130b-3p Mediates DENND1A Variant 2 Expression and Androgen Biosynthesis.
    7. we evaluated the frequencies of CYP19A1 rs2414096 and DENND1A rs10818854 polymorphisms in overweight and normal individuals and didn't find any significant difference between these groups which demonstrates a lack of association between obesity risk and these SNPs
      Title: The role of DENND1A and CYP19A1 gene variants in individual susceptibility to obesity in Turkish population-a preliminary study.
    8. The association of DENND1A rs10818854 and rs10986105 variants with PCOS in Tunisian but not Bahraini women confirms the dependence of this association on the ethnic/racial origin of study subjects.
      Title: Differential association of DENND1A genetic variants with polycystic ovary syndrome in Tunisian but not Bahraini Arab women.
    9. Genome-wide association studies have identified DENND1A as a candidate gene for polycystic ovary syndrome (PCOS). PCOS theca cells are shown to overexpress DENND1A splice variant 2 (V2), but not V1. Also, the genetic variation 330 bp upstream of exon 20A is not associated with VE variant expression.
      Title: Alternative splicing of DENND1A, a PCOS candidate gene, generates variant 2.
    10. DENND1A gene variant is likely to have influence on PCOS risk.
      Title: The association of DENND1A gene polymorphisms and polycystic ovary syndrome risk: a systematic review and meta-analysis.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
    EBI GWAS Catalog
    A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.
    EBI GWAS Catalog
    A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
    EBI GWAS Catalog
    Genome-wide association of body fat distribution in African ancestry populations suggests new loci.
    EBI GWAS Catalog
    Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
    EBI GWAS Catalog
    Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.
    EBI GWAS Catalog
    Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ38464

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Rab protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 1A
    Names
    DENN/MADD domain containing 1A
    connecdenn 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001352964.2 → NP_001339893.1  DENN domain-containing protein 1A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AC006450, AL161790, AL390774, AL445489
      Consensus CDS
      CCDS94479.1
      UniProtKB/TrEMBL
      A0A0A0MS48
      Related
      ENSP00000377763.4, ENST00000394215.7
      Conserved Domains (4) summary
      smart00801
      Location:305 → 371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95 → 273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 91
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cl26464
      Location:705 → 1056
      Atrophin-1; Atrophin-1 family

    2. NM_001352965.2 → NP_001339894.1  DENN domain-containing protein 1A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC006450, AL161790, AL390774, AL445489
      UniProtKB/TrEMBL
      Q9HCG4
      Conserved Domains (4) summary
      smart00801
      Location:273 → 339
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:63 → 241
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:10 → 59
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cl26464
      Location:655 → 1006
      Atrophin-1; Atrophin-1 family

    3. NM_001352966.2 → NP_001339895.1  DENN domain-containing protein 1A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC006450, AL161790, AL390774, AL445489
      Conserved Domains (3) summary
      smart00801
      Location:275 → 341
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:65 → 243
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:14 → 61
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    4. NM_001352967.2 → NP_001339896.1  DENN domain-containing protein 1A isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC006450, AL161790, AL390774, AL445489
      Conserved Domains (3) summary
      smart00801
      Location:273 → 339
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:63 → 241
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:26 → 59
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    5. NM_001352968.2 → NP_001339897.1  DENN domain-containing protein 1A isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC006450, AL161790, AL390774, AL445489
      Consensus CDS
      CCDS87687.1
      Related
      ENSP00000362720.1, ENST00000373618.1
      Conserved Domains (3) summary
      smart00801
      Location:273 → 339
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:63 → 241
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl04085
      Location:26 → 59
      uDENN; uDENN domain

    6. NM_001393654.1 → NP_001380583.1  DENN domain-containing protein 1A isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC006450, AL161790, AL390774, AL445489
      UniProtKB/TrEMBL
      Q9HCG4
      Conserved Domains (4) summary
      smart00801
      Location:305 → 371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95 → 273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 91
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      PHA03247
      Location:687 → 1038
      PHA03247; large tegument protein UL36; Provisional

    7. NM_001400446.1 → NP_001387375.1  DENN domain-containing protein 1A isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC006450, AL161790, AL390774, AL445489

    8. NM_001400449.1 → NP_001387378.1  DENN domain-containing protein 1A isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC006450, AL161790, AL390774, AL445489

    9. NM_020946.2 → NP_065997.1  DENN domain-containing protein 1A isoform 1

      See identical proteins and their annotated locations for NP_065997.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC006450, AL161790, AL390774, AL445489
      Consensus CDS
      CCDS35133.1
      UniProtKB/Swiss-Prot
      A8MZA3, B1AM80, B7Z3C8, B7Z669, D3PFD3, Q05C88, Q5VWF0, Q6PJZ5, Q8IVD6, Q8TEH3, Q9H796
      UniProtKB/TrEMBL
      Q9HCG4
      Related
      ENSP00000362727.2, ENST00000373624.6
      Conserved Domains (3) summary
      smart00801
      Location:305 → 371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95 → 273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 91
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    10. NM_024820.3 → NP_079096.2  DENN domain-containing protein 1A isoform 2

      See identical proteins and their annotated locations for NP_079096.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding region compared to variant 1, that causes a frameshift. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL445489, BC009616, BC028061, BC039703
      Consensus CDS
      CCDS35134.1
      UniProtKB/Swiss-Prot
      Q8TEH3
      Related
      ENSP00000362722.3, ENST00000373620.7
      Conserved Domains (3) summary
      smart00801
      Location:305 → 371
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:95 → 273
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 91
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    RNA

    1. NR_148208.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC006450, AL161790, AL390774, AL445489

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      123379658..123930126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423624.1 → XP_047279580.1  DENN domain-containing protein 1A isoform X18

    2. XM_047423622.1 → XP_047279578.1  DENN domain-containing protein 1A isoform X16

    3. XM_024447622.2 → XP_024303390.1  DENN domain-containing protein 1A isoform X9

      UniProtKB/TrEMBL
      Q9HCG4
      Conserved Domains (4) summary
      smart00801
      Location:275 → 341
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:65 → 243
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:14 → 61
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cl26464
      Location:675 → 1026
      Atrophin-1; Atrophin-1 family

    4. XM_047423625.1 → XP_047279581.1  DENN domain-containing protein 1A isoform X19

    5. XM_047423623.1 → XP_047279579.1  DENN domain-containing protein 1A isoform X17

    6. XM_024447621.2 → XP_024303389.1  DENN domain-containing protein 1A isoform X10

      UniProtKB/TrEMBL
      Q9HCG4
      Conserved Domains (4) summary
      smart00801
      Location:273 → 339
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:63 → 241
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:26 → 59
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cl26464
      Location:673 → 1024
      Atrophin-1; Atrophin-1 family

    7. XM_047423621.1 → XP_047279577.1  DENN domain-containing protein 1A isoform X15

    8. XM_047423618.1 → XP_047279574.1  DENN domain-containing protein 1A isoform X11

    9. XM_011518882.4 → XP_011517184.1  DENN domain-containing protein 1A isoform X2

      Conserved Domains (3) summary
      smart00801
      Location:320 → 386
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:110 → 288
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:24 → 106
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    10. XM_006717195.5 → XP_006717258.1  DENN domain-containing protein 1A isoform X5

      Conserved Domains (3) summary
      smart00801
      Location:320 → 386
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:110 → 288
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:24 → 106
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    11. XM_011518886.4 → XP_011517188.1  DENN domain-containing protein 1A isoform X8

      Conserved Domains (3) summary
      smart00801
      Location:320 → 386
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:110 → 288
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:24 → 106
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    12. XM_005252111.5 → XP_005252168.1  DENN domain-containing protein 1A isoform X13

      Conserved Domains (3) summary
      smart00801
      Location:320 → 386
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:110 → 288
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:24 → 106
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    13. XM_011518885.4 → XP_011517187.1  DENN domain-containing protein 1A isoform X6

      UniProtKB/TrEMBL
      Q9HCG4
      Related
      ENST00000473039.5
      Conserved Domains (3) summary
      smart00801
      Location:284 → 350
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:74 → 252
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:9 → 70
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    14. XM_047423615.1 → XP_047279571.1  DENN domain-containing protein 1A isoform X4

    15. XM_047423613.1 → XP_047279569.1  DENN domain-containing protein 1A isoform X1

    16. XM_047423620.1 → XP_047279576.1  DENN domain-containing protein 1A isoform X14

    17. XM_047423614.1 → XP_047279570.1  DENN domain-containing protein 1A isoform X3

    18. XM_047423616.1 → XP_047279572.1  DENN domain-containing protein 1A isoform X7

    19. XM_047423619.1 → XP_047279575.1  DENN domain-containing protein 1A isoform X12

    20. XM_024447623.2 → XP_024303391.1  DENN domain-containing protein 1A isoform X20

      UniProtKB/TrEMBL
      Q9HCG4
      Conserved Domains (3) summary
      smart00801
      Location:109 → 175
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:4 → 77
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      cl26464
      Location:509 → 860
      Atrophin-1; Atrophin-1 family

    21. XM_047423630.1 → XP_047279586.1  DENN domain-containing protein 1A isoform X26

    22. XM_047423631.1 → XP_047279587.1  DENN domain-containing protein 1A isoform X27

    23. XM_047423627.1 → XP_047279583.1  DENN domain-containing protein 1A isoform X22

    24. XM_005252113.6 → XP_005252170.1  DENN domain-containing protein 1A isoform X24

      Conserved Domains (3) summary
      smart00801
      Location:320 → 386
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:110 → 288
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:24 → 106
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    25. XM_047423626.1 → XP_047279582.1  DENN domain-containing protein 1A isoform X21

    26. XM_047423629.1 → XP_047279585.1  DENN domain-containing protein 1A isoform X25

    27. XM_047423628.1 → XP_047279584.1  DENN domain-containing protein 1A isoform X23

    28. XM_047423633.1 → XP_047279589.1  DENN domain-containing protein 1A isoform X29

    29. XM_047423632.1 → XP_047279588.1  DENN domain-containing protein 1A isoform X28

    RNA

    1. XR_007061334.1 RNA Sequence

    2. XR_007061335.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      135577391..136128012 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363366.1 → XP_054219341.1  DENN domain-containing protein 1A isoform X18

    2. XM_054363364.1 → XP_054219339.1  DENN domain-containing protein 1A isoform X16

    3. XM_054363357.1 → XP_054219332.1  DENN domain-containing protein 1A isoform X9

    4. XM_054363367.1 → XP_054219342.1  DENN domain-containing protein 1A isoform X19

    5. XM_054363365.1 → XP_054219340.1  DENN domain-containing protein 1A isoform X17

    6. XM_054363358.1 → XP_054219333.1  DENN domain-containing protein 1A isoform X10

    7. XM_054363363.1 → XP_054219338.1  DENN domain-containing protein 1A isoform X15

    8. XM_054363359.1 → XP_054219334.1  DENN domain-containing protein 1A isoform X11

    9. XM_054363350.1 → XP_054219325.1  DENN domain-containing protein 1A isoform X2

    10. XM_054363353.1 → XP_054219328.1  DENN domain-containing protein 1A isoform X5

    11. XM_054363356.1 → XP_054219331.1  DENN domain-containing protein 1A isoform X8

    12. XM_054363361.1 → XP_054219336.1  DENN domain-containing protein 1A isoform X13

    13. XM_054363354.1 → XP_054219329.1  DENN domain-containing protein 1A isoform X6

    14. XM_054363352.1 → XP_054219327.1  DENN domain-containing protein 1A isoform X4

    15. XM_054363349.1 → XP_054219324.1  DENN domain-containing protein 1A isoform X1

    16. XM_054363362.1 → XP_054219337.1  DENN domain-containing protein 1A isoform X14

    17. XM_054363351.1 → XP_054219326.1  DENN domain-containing protein 1A isoform X3

    18. XM_054363355.1 → XP_054219330.1  DENN domain-containing protein 1A isoform X7

    19. XM_054363360.1 → XP_054219335.1  DENN domain-containing protein 1A isoform X12

    20. XM_054363372.1 → XP_054219347.1  DENN domain-containing protein 1A isoform X26

    21. XM_054363373.1 → XP_054219348.1  DENN domain-containing protein 1A isoform X27

    22. XM_054363368.1 → XP_054219343.1  DENN domain-containing protein 1A isoform X22

    23. XM_054363370.1 → XP_054219345.1  DENN domain-containing protein 1A isoform X24

    24. XM_054363371.1 → XP_054219346.1  DENN domain-containing protein 1A isoform X25

    25. XM_054363369.1 → XP_054219344.1  DENN domain-containing protein 1A isoform X23

    26. XM_054363375.1 → XP_054219350.1  DENN domain-containing protein 1A isoform X29

    27. XM_054363374.1 → XP_054219349.1  DENN domain-containing protein 1A isoform X28

    RNA

    1. XR_008488053.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TEH3.2 GenPept UniProtKB/Swiss-Prot:Q8TEH3

    Gene LinkOut

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