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    KATNBL1 katanin regulatory subunit B1 like 1 [ Homo sapiens (human) ]

    Gene ID: 79768, updated on 26-Nov-2024

    Summary

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    Official Symbol
    KATNBL1provided by HGNC
    Official Full Name
    katanin regulatory subunit B1 like 1provided by HGNC
    Primary source
    HGNC:HGNC:26199
    See related
    Ensembl:ENSG00000134152 MIM:616235; AllianceGenome:HGNC:26199
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C15orf29
    Summary
    Predicted to enable microtubule binding activity. Involved in cytoplasmic microtubule organization and positive regulation of cytoskeleton organization. Located in several cellular components, including cleavage furrow; mitotic spindle pole; and nuclear lumen. Part of katanin complex. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 6.9), esophagus (RPKM 6.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KATNBL1 in Genome Data Viewer
    Location:
    15q14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (34140674..34210096, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (31938913..32008344, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (34432875..34502297, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:34393207-34394064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9174 Neighboring gene ribosomal protein L32 pseudogene 2 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene piggyBac transposable element derived 4 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:34446570-34447769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6277 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:34506245-34506840 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9175 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:34531007-34532206 Neighboring gene uncharacterized LOC124903461 Neighboring gene solute carrier family 12 member 6 Neighboring gene ER membrane protein complex subunit 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The spindle assembly function of Caenorhabditis elegans katanin does not require microtubule-severing activity. McNally KP, et al. Mol Biol Cell, 2011 May. PMID 21372175, Free PMC Article
    2. Microtubule minus-end regulation at spindle poles by an ASPM-katanin complex. Jiang K, et al. Nat Cell Biol, 2017 May. PMID 28436967, Free PMC Article
    3. Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing. Cheung K, et al. Mol Cell Proteomics, 2016 May. PMID 26929214, Free PMC Article
    4. Network-based prediction of protein interactions. Kovács IA, et al. Nat Commun, 2019 Mar 18. PMID 30886144, Free PMC Article
    5. Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs. Almasy KM, et al. Mol Cell Proteomics, 2021. PMID 34186245, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that KATNBL1 functions as a regulator of Katanin A subunit microtubule-severing activity during mitosis and that it likely coordinates with KATNB1 to perform this function.
      Title: Proteomic Analysis of the Mammalian Katanin Family of Microtubule-severing Enzymes Defines Katanin p80 subunit B-like 1 (KATNBL1) as a Regulator of Mammalian Katanin Microtubule-severing.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic microtubule organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of katanin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of katanin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microtubule cytoskeleton NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in mitotic spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    KATNB1-like protein 1
    Names
    katanin p80 subunit B-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024713.3 → NP_078989.1  KATNB1-like protein 1

      See identical proteins and their annotated locations for NP_078989.1

      Status: VALIDATED

      Source sequence(s)
      AK311338, AL136908, BC026234, BM831547, BX389537
      Consensus CDS
      CCDS10034.1
      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670
      Related
      ENSP00000256544.3, ENST00000256544.8
      Conserved Domains (1) summary
      pfam13925
      Location:153 → 296
      Katanin_con80; con80 domain of Katanin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      34140674..34210096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022575.3 → XP_016878064.1  KATNB1-like protein 1 isoform X3

      UniProtKB/TrEMBL
      B4DNG1

    2. XM_047433041.1 → XP_047288997.1  KATNB1-like protein 1 isoform X3

    3. XM_017022571.3 → XP_016878060.1  KATNB1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670
      Conserved Domains (1) summary
      pfam13925
      Location:153 → 296
      Katanin_con80; con80 domain of Katanin

    4. XM_047433037.1 → XP_047288993.1  KATNB1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670

    5. XM_047433036.1 → XP_047288992.1  KATNB1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670

    6. XM_017022574.2 → XP_016878063.1  KATNB1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670
      Conserved Domains (1) summary
      pfam13925
      Location:153 → 296
      Katanin_con80; con80 domain of Katanin

    7. XM_047433038.1 → XP_047288994.1  KATNB1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670

    8. XM_017022573.3 → XP_016878062.1  KATNB1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670
      Conserved Domains (1) summary
      pfam13925
      Location:153 → 296
      Katanin_con80; con80 domain of Katanin

    9. XM_005254668.5 → XP_005254725.1  KATNB1-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_005254725.1

      Conserved Domains (1) summary
      pfam13925
      Location:153 → 296
      Katanin_con80; con80 domain of Katanin

    10. XM_047433040.1 → XP_047288996.1  KATNB1-like protein 1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      31938913..32008344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378793.1 → XP_054234768.1  KATNB1-like protein 1 isoform X3

    2. XM_054378794.1 → XP_054234769.1  KATNB1-like protein 1 isoform X3

    3. XM_054378785.1 → XP_054234760.1  KATNB1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670

    4. XM_054378788.1 → XP_054234763.1  KATNB1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670

    5. XM_054378786.1 → XP_054234761.1  KATNB1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670

    6. XM_054378789.1 → XP_054234764.1  KATNB1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670

    7. XM_054378790.1 → XP_054234765.1  KATNB1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670

    8. XM_054378787.1 → XP_054234762.1  KATNB1-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      A8KAF6, Q2TAC0, Q9H079, Q9H670

    9. XM_054378791.1 → XP_054234766.1  KATNB1-like protein 1 isoform X2

    10. XM_054378792.1 → XP_054234767.1  KATNB1-like protein 1 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H079.1 GenPept UniProtKB/Swiss-Prot:Q9H079

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