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    MYO19 myosin XIX [ Homo sapiens (human) ]

    Gene ID: 80179, updated on 14-Nov-2024

    Summary

    Official Symbol
    MYO19provided by HGNC
    Official Full Name
    myosin XIXprovided by HGNC
    Primary source
    HGNC:HGNC:26234
    See related
    Ensembl:ENSG00000278259 MIM:617379; AllianceGenome:HGNC:26234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MYOHD1
    Summary
    Enables ATP hydrolysis activity and actin binding activity. Involved in regulation of cytokinesis and regulation of mitochondrial fission. Acts upstream of or within mitochondrion migration along actin filament. Located in cytosol and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in skin (RPKM 10.8), esophagus (RPKM 7.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MYO19 in Genome Data Viewer
    Location:
    17q12
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (36495636..36544815, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (37481389..37530568, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34851480..34890695, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371749 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:34842246-34843179 Neighboring gene RNA, 5S ribosomal pseudogene 439 Neighboring gene zinc finger HIT-type containing 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:34889386-34890061 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class W Neighboring gene gametogenetin binding protein 2 Neighboring gene ribosomal protein S2 pseudogene 50 Neighboring gene uncharacterized LOC107985031 Neighboring gene dehydrogenase/reductase 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ22865

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables myosin light chain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables plus-end directed microfilament motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within mitochondrion migration along actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mitocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    unconventional myosin-XIX
    Names
    myosin head domain containing 1
    myosin head domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033580.3NP_001028752.1  unconventional myosin-XIX isoform 3

      See identical proteins and their annotated locations for NP_001028752.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 3' coding region, 3' UTR, and poly-adenylation signal, compared to variant 2. The resulting isoform (3) has a substantially shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AC233698
      Consensus CDS
      CCDS59283.1
      Related
      ENSP00000477559.1, ENST00000621344.4
      Conserved Domains (1) summary
      cl22853
      Location:49299
      Motor_domain; Myosin and Kinesin motor domain
    2. NM_001163735.2NP_001157207.1  unconventional myosin-XIX isoform 2

      See identical proteins and their annotated locations for NP_001157207.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AC233698
      Consensus CDS
      CCDS54112.1
      UniProtKB/Swiss-Prot
      Q59GS4, Q96H55, Q9H5X2
      UniProtKB/TrEMBL
      B4E218
      Related
      ENSP00000479518.1, ENST00000614623.5
      Conserved Domains (2) summary
      smart00242
      Location:36754
      MYSc; Myosin. Large ATPases
      cd14880
      Location:49746
      MYSc_Myo19; class XIX myosin, motor domain
    3. NM_025109.6NP_079385.2  unconventional myosin-XIX isoform 1

      See identical proteins and their annotated locations for NP_079385.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame segment, compared to variant 2. The resulting isoform (1) lacks an internal segment in the central coding region, compared to isoform 2.
      Source sequence(s)
      AC233698
      Consensus CDS
      CCDS45654.1
      UniProtKB/Swiss-Prot
      Q96H55
      UniProtKB/TrEMBL
      B4E218, B7Z1T7
      Related
      ENSP00000478437.1, ENST00000610930.4
      Conserved Domains (1) summary
      cl22853
      Location:49439
      Motor_domain; Myosin and Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      36495636..36544815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436823.1XP_047292779.1  unconventional myosin-XIX isoform X1

    2. XM_047436835.1XP_047292791.1  unconventional myosin-XIX isoform X10

      UniProtKB/Swiss-Prot
      Q59GS4, Q96H55, Q9H5X2
    3. XM_047436826.1XP_047292782.1  unconventional myosin-XIX isoform X4

    4. XM_024450955.2XP_024306723.1  unconventional myosin-XIX isoform X1

      UniProtKB/TrEMBL
      B4E218
      Conserved Domains (1) summary
      cd14880
      Location:49823
      MYSc_Myo19; class XIX myosin, motor domain
    5. XM_047436840.1XP_047292796.1  unconventional myosin-XIX isoform X16

    6. XM_047436839.1XP_047292795.1  unconventional myosin-XIX isoform X15

    7. XM_047436830.1XP_047292786.1  unconventional myosin-XIX isoform X9

    8. XM_017025158.3XP_016880647.1  unconventional myosin-XIX isoform X4

      UniProtKB/TrEMBL
      B4E218
      Conserved Domains (1) summary
      cd14880
      Location:49792
      MYSc_Myo19; class XIX myosin, motor domain
    9. XM_047436837.1XP_047292793.1  unconventional myosin-XIX isoform X13

    10. XM_011525290.4XP_011523592.1  unconventional myosin-XIX isoform X6

      See identical proteins and their annotated locations for XP_011523592.1

      UniProtKB/TrEMBL
      B4E218
      Conserved Domains (2) summary
      smart00242
      Location:36785
      MYSc; Myosin. Large ATPases
      cd14880
      Location:49777
      MYSc_Myo19; class XIX myosin, motor domain
    11. XM_047436836.1XP_047292792.1  unconventional myosin-XIX isoform X12

    12. XM_017025159.3XP_016880648.1  unconventional myosin-XIX isoform X5

      UniProtKB/TrEMBL
      B4E218
    13. XM_011525287.3XP_011523589.1  unconventional myosin-XIX isoform X2

      See identical proteins and their annotated locations for XP_011523589.1

      UniProtKB/TrEMBL
      B4E218
      Conserved Domains (2) summary
      smart00242
      Location:36829
      MYSc; Myosin. Large ATPases
      cd14880
      Location:49821
      MYSc_Myo19; class XIX myosin, motor domain
    14. XM_017025160.3XP_016880649.1  unconventional myosin-XIX isoform X11

      UniProtKB/TrEMBL
      B4E218
    15. XM_011525286.3XP_011523588.1  unconventional myosin-XIX isoform X1

      See identical proteins and their annotated locations for XP_011523588.1

      UniProtKB/TrEMBL
      B4E218
      Conserved Domains (1) summary
      cd14880
      Location:49823
      MYSc_Myo19; class XIX myosin, motor domain
    16. XM_047436838.1XP_047292794.1  unconventional myosin-XIX isoform X14

    17. XM_047436829.1XP_047292785.1  unconventional myosin-XIX isoform X8

    18. XM_047436828.1XP_047292784.1  unconventional myosin-XIX isoform X7

    19. XM_047436824.1XP_047292780.1  unconventional myosin-XIX isoform X21

    20. XM_047436825.1XP_047292781.1  unconventional myosin-XIX isoform X3

    21. XM_047436842.1XP_047292798.1  unconventional myosin-XIX isoform X16

    22. XM_047436834.1XP_047292790.1  unconventional myosin-XIX isoform X10

      UniProtKB/Swiss-Prot
      Q59GS4, Q96H55, Q9H5X2
    23. XM_047436832.1XP_047292788.1  unconventional myosin-XIX isoform X9

    24. XM_017025157.2XP_016880646.1  unconventional myosin-XIX isoform X1

      UniProtKB/TrEMBL
      B4E218
      Conserved Domains (1) summary
      cd14880
      Location:49823
      MYSc_Myo19; class XIX myosin, motor domain
    25. XM_047436841.1XP_047292797.1  unconventional myosin-XIX isoform X16

    26. XM_047436833.1XP_047292789.1  unconventional myosin-XIX isoform X10

      UniProtKB/Swiss-Prot
      Q59GS4, Q96H55, Q9H5X2
    27. XM_047436831.1XP_047292787.1  unconventional myosin-XIX isoform X9

    28. XM_024450956.2XP_024306724.1  unconventional myosin-XIX isoform X4

      UniProtKB/TrEMBL
      B4E218
      Conserved Domains (1) summary
      cd14880
      Location:49792
      MYSc_Myo19; class XIX myosin, motor domain
    29. XM_047436827.1XP_047292783.1  unconventional myosin-XIX isoform X6

    30. XM_024450954.2XP_024306722.1  unconventional myosin-XIX isoform X1

      UniProtKB/TrEMBL
      B4E218
      Conserved Domains (1) summary
      cd14880
      Location:49823
      MYSc_Myo19; class XIX myosin, motor domain
    31. XM_047436844.1XP_047292800.1  unconventional myosin-XIX isoform X18

    32. XM_047436843.1XP_047292799.1  unconventional myosin-XIX isoform X17

    33. XM_047436845.1XP_047292801.1  unconventional myosin-XIX isoform X19

      Related
      ENSP00000480125.1, ENST00000610992.4
    34. XM_047436846.1XP_047292802.1  unconventional myosin-XIX isoform X20

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      730540..779719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329348.1XP_054185323.1  unconventional myosin-XIX isoform X1

    2. XM_054329363.1XP_054185338.1  unconventional myosin-XIX isoform X10

      UniProtKB/Swiss-Prot
      Q59GS4, Q96H55, Q9H5X2
    3. XM_054329362.1XP_054185337.1  unconventional myosin-XIX isoform X10

      UniProtKB/Swiss-Prot
      Q59GS4, Q96H55, Q9H5X2
    4. XM_054329364.1XP_054185339.1  unconventional myosin-XIX isoform X10

      UniProtKB/Swiss-Prot
      Q59GS4, Q96H55, Q9H5X2
    5. XM_054329353.1XP_054185328.1  unconventional myosin-XIX isoform X4

    6. XM_054329345.1XP_054185320.1  unconventional myosin-XIX isoform X1

    7. XM_054329372.1XP_054185347.1  unconventional myosin-XIX isoform X16

    8. XM_054329361.1XP_054185336.1  unconventional myosin-XIX isoform X9

    9. XM_054329344.1XP_054185319.1  unconventional myosin-XIX isoform X1

    10. XM_054329360.1XP_054185335.1  unconventional myosin-XIX isoform X9

    11. XM_054329370.1XP_054185345.1  unconventional myosin-XIX isoform X16

    12. XM_054329369.1XP_054185344.1  unconventional myosin-XIX isoform X15

    13. XM_054329359.1XP_054185334.1  unconventional myosin-XIX isoform X9

    14. XM_054329351.1XP_054185326.1  unconventional myosin-XIX isoform X4

    15. XM_054329367.1XP_054185342.1  unconventional myosin-XIX isoform X13

    16. XM_054329355.1XP_054185330.1  unconventional myosin-XIX isoform X6

    17. XM_054329366.1XP_054185341.1  unconventional myosin-XIX isoform X12

    18. XM_054329354.1XP_054185329.1  unconventional myosin-XIX isoform X5

    19. XM_054329349.1XP_054185324.1  unconventional myosin-XIX isoform X2

    20. XM_054329365.1XP_054185340.1  unconventional myosin-XIX isoform X11

    21. XM_054329346.1XP_054185321.1  unconventional myosin-XIX isoform X1

    22. XM_054329371.1XP_054185346.1  unconventional myosin-XIX isoform X16

    23. XM_054329352.1XP_054185327.1  unconventional myosin-XIX isoform X4

    24. XM_054329356.1XP_054185331.1  unconventional myosin-XIX isoform X6

    25. XM_054329347.1XP_054185322.1  unconventional myosin-XIX isoform X1

    26. XM_054329368.1XP_054185343.1  unconventional myosin-XIX isoform X14

    27. XM_054329358.1XP_054185333.1  unconventional myosin-XIX isoform X8

    28. XM_054329357.1XP_054185332.1  unconventional myosin-XIX isoform X7

    29. XM_054329350.1XP_054185325.1  unconventional myosin-XIX isoform X3

    30. XM_054329374.1XP_054185349.1  unconventional myosin-XIX isoform X18

    31. XM_054329373.1XP_054185348.1  unconventional myosin-XIX isoform X17

    32. XM_054329375.1XP_054185350.1  unconventional myosin-XIX isoform X19

    33. XM_054329376.1XP_054185351.1  unconventional myosin-XIX isoform X20

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      37481389..37530568 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317373.1XP_054173348.1  unconventional myosin-XIX isoform X1

    2. XM_054317388.1XP_054173363.1  unconventional myosin-XIX isoform X10

      UniProtKB/Swiss-Prot
      Q59GS4, Q96H55, Q9H5X2
    3. XM_054317387.1XP_054173362.1  unconventional myosin-XIX isoform X10

      UniProtKB/Swiss-Prot
      Q59GS4, Q96H55, Q9H5X2
    4. XM_054317389.1XP_054173364.1  unconventional myosin-XIX isoform X10

      UniProtKB/Swiss-Prot
      Q59GS4, Q96H55, Q9H5X2
    5. XM_054317378.1XP_054173353.1  unconventional myosin-XIX isoform X4

    6. XM_054317372.1XP_054173347.1  unconventional myosin-XIX isoform X1

    7. XM_054317397.1XP_054173372.1  unconventional myosin-XIX isoform X16

    8. XM_054317386.1XP_054173361.1  unconventional myosin-XIX isoform X9

    9. XM_054317369.1XP_054173344.1  unconventional myosin-XIX isoform X1

    10. XM_054317385.1XP_054173360.1  unconventional myosin-XIX isoform X9

    11. XM_054317395.1XP_054173370.1  unconventional myosin-XIX isoform X16

    12. XM_054317394.1XP_054173369.1  unconventional myosin-XIX isoform X15

    13. XM_054317384.1XP_054173359.1  unconventional myosin-XIX isoform X9

    14. XM_054317376.1XP_054173351.1  unconventional myosin-XIX isoform X4

    15. XM_054317392.1XP_054173367.1  unconventional myosin-XIX isoform X13

    16. XM_054317380.1XP_054173355.1  unconventional myosin-XIX isoform X6

    17. XM_054317391.1XP_054173366.1  unconventional myosin-XIX isoform X12

    18. XM_054317379.1XP_054173354.1  unconventional myosin-XIX isoform X5

    19. XM_054317374.1XP_054173349.1  unconventional myosin-XIX isoform X2

    20. XM_054317390.1XP_054173365.1  unconventional myosin-XIX isoform X11

    21. XM_054317370.1XP_054173345.1  unconventional myosin-XIX isoform X1

    22. XM_054317396.1XP_054173371.1  unconventional myosin-XIX isoform X16

    23. XM_054317377.1XP_054173352.1  unconventional myosin-XIX isoform X4

    24. XM_054317381.1XP_054173356.1  unconventional myosin-XIX isoform X6

    25. XM_054317371.1XP_054173346.1  unconventional myosin-XIX isoform X1

    26. XM_054317393.1XP_054173368.1  unconventional myosin-XIX isoform X14

    27. XM_054317383.1XP_054173358.1  unconventional myosin-XIX isoform X8

    28. XM_054317382.1XP_054173357.1  unconventional myosin-XIX isoform X7

    29. XM_054317375.1XP_054173350.1  unconventional myosin-XIX isoform X3

    30. XM_054317399.1XP_054173374.1  unconventional myosin-XIX isoform X18

    31. XM_054317398.1XP_054173373.1  unconventional myosin-XIX isoform X17

    32. XM_054317400.1XP_054173375.1  unconventional myosin-XIX isoform X19

    33. XM_054317401.1XP_054173376.1  unconventional myosin-XIX isoform X20

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033579.1: Suppressed sequence

      Description
      NM_001033579.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.