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    FRAT1 FRAT regulator of WNT signaling pathway 1 [ Homo sapiens (human) ]

    Gene ID: 10023, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FRAT1provided by HGNC
    Official Full Name
    FRAT regulator of WNT signaling pathway 1provided by HGNC
    Primary source
    HGNC:HGNC:3944
    See related
    Ensembl:ENSG00000165879 MIM:602503; AllianceGenome:HGNC:3944
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]
    Orthologs
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    Genomic context

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    See FRAT1 in Genome Data Viewer
    Location:
    10q24.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97319271..97321915)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98199470..98202113)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99079028..99081672)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ARHGAP19-SLIT1 readthrough (NMD candidate) Neighboring gene uncharacterized LOC105378447 Neighboring gene Rho GTPase activating protein 19 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99027352-99027856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:99049689-99050447 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99051206-99051964 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99051965-99052721 Neighboring gene Sharpr-MPRA regulatory region 7927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2671 Neighboring gene ribosomal protein L12 pseudogene 27 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99093197-99094104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2675 Neighboring gene uncharacterized LOC105378448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2676 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:99096642-99097160 Neighboring gene FRAT regulator of WNT signaling pathway 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The expression profile of FRAT1 in human gliomas. Guo G, et al. Brain Res, 2010 Mar 12. PMID 20096670
    2. Overexpression of Frat1 correlates with malignant phenotype and advanced stage in human non-small cell lung cancer. Zhang Y, et al. Virchows Arch, 2011 Sep. PMID 21818639
    3. FRAT1 expression and its correlation with pathologic grade, proliferation, and apoptosis in human astrocytomas. Guo G, et al. Med Oncol, 2011 Mar. PMID 20041315
    4. FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer. Saitoh T, et al. Int J Oncol, 2001 Aug. PMID 11445844
    5. Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells. Fan WH, et al. Oncol Rep, 2016 Nov. PMID 27666874

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells.
      Title: The miR-3648/FRAT1-FRAT2/c-Myc negative feedback loop modulates the metastasis and invasion of gastric cancer cells.
    2. FRAT1 promotes the angiogenic properties of human glioblastoma cells via VEGFA.
      Title: FRAT1 promotes the angiogenic properties of human glioblastoma cells via VEGFA.
    3. LncRNA CCAT1 promotes prostate cancer cells proliferation, migration, and invasion through regulation of miR-490-3p/FRAT1 axis.
      Title: LncRNA CCAT1 promotes prostate cancer cells proliferation, migration, and invasion through regulation of miR-490-3p/FRAT1 axis.
    4. The results of the present study suggest that nuclear FRAT1 activates the Wnt/beta-catenin signaling pathway and confers an increase in prostate cancer cell growth.
      Title: Frequently rearranged in advanced T‑cell lymphomas‑1 demonstrates oncogenic properties in prostate cancer.
    5. These data suggest a potential role for targeting FRAT1 in the prevention of hypoxia-induced HCC cancer progression and metastasis mediated by epithelial-to-mesenchymal transition
      Title: Knockdown of FRAT1 inhibits hypoxia-induced epithelial-to-mesenchymal transition via suppression of the Wnt/β-catenin pathway in hepatocellular carcinoma cells.
    6. FRAT1 and ABCG2 overexpression is associated with carcinogenesis, progression, and poor prognosis in patients with Pancreatic ductal adenocarcinoma.
      Title: The clinical significance of FRAT1 and ABCG2 expression in pancreatic ductal adenocarcinoma.
    7. Positive ROR2 and FRAT1 expression is associated with the progression and poor prognosis of chondrosarcoma.
      Title: The clinical pathological significance of FRAT1 and ROR2 expression in cartilage tumors.
    8. FRAT1 overexpression correlates with pathologic grade, proliferation, invasion and angiogenesis in brain gliomas.
      Title: Overexpression of FRAT1 is associated with malignant phenotype and poor prognosis in human gliomas.
    9. The mechanism of inhibiting beta-catenin phosphorylation involves the NDRG1-mediated upregulation of the GSK3beta-binding protein FRAT1.
      Title: The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4.
    10. These results highlight the potential role of FRAT1 in tumorigenesis and progression of glioblastoma.
      Title: Knockdown of FRAT1 expression by RNA interference inhibits human glioblastoma cell growth, migration and invasion.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ97193

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular function inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proto-oncogene FRAT1
    Names
    FRAT-1
    FRAT1, WNT signaling pathway regulator
    frequently rearranged in advanced T-cell lymphomas 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005479.4 → NP_005470.2  proto-oncogene FRAT1

      See identical proteins and their annotated locations for NP_005470.2

      Status: REVIEWED

      Source sequence(s)
      AL355490
      Consensus CDS
      CCDS7455.1
      UniProtKB/Swiss-Prot
      Q5JTI1, Q8NE74, Q8TDW9, Q92837
      Related
      ENSP00000360060.3, ENST00000371021.5
      Conserved Domains (1) summary
      pfam05350
      Location:1 → 239
      GSK-3_bind; Glycogen synthase kinase-3 binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      97319271..97321915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      98199470..98202113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181355.1: Suppressed sequence

      Description
      NM_181355.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92837.3 GenPept UniProtKB/Swiss-Prot:Q92837

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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