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    SEC61G SEC61 translocon subunit gamma [ Homo sapiens (human) ]

    Gene ID: 23480, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SEC61Gprovided by HGNC
    Official Full Name
    SEC61 translocon subunit gammaprovided by HGNC
    Primary source
    HGNC:HGNC:18277
    See related
    Ensembl:ENSG00000132432 MIM:609215; AllianceGenome:HGNC:18277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SSS1
    Summary
    The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in colon (RPKM 71.5), prostate (RPKM 56.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SEC61G in Genome Data Viewer
    Location:
    7p11.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (54752253..54759211, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (54912179..54919137, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (54819946..54826904, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1125, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:54731509-54732224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:54732225-54732940 Neighboring gene ribosomal protein L31 pseudogene 35 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:54742531-54743176 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:54743177-54743822 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:54748033-54748601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18184 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:54827107-54828042 Neighboring gene SEC61G divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18185 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:54847531-54848394 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:54848395-54849258 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:54849259-54850122 Neighboring gene negCOR silencer S2 Neighboring gene uncharacterized LOC124901636

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK Signaling Pathway. Fan Y, et al. Dis Markers, 2022. PMID 36092956, Free PMC Article
    2. Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation. Zheng Q, et al. BMC Cancer, 2021 Nov 13. PMID 34774014, Free PMC Article
    3. SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma. Lu T, et al. Cancer Med, 2021 Nov. PMID 34590792, Free PMC Article
    4. Identification of SEC61G as a Novel Prognostic Marker for Predicting Survival and Response to Therapies in Patients with Glioblastoma. Liu B, et al. Med Sci Monit, 2019 May 16. PMID 31094363, Free PMC Article
    5. SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma. Shi Y, et al. Eur Arch Otorhinolaryngol, 2022 Apr. PMID 34173014, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis.
      Title: Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis.
    2. SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK Signaling Pathway.
      Title: SEC61G Promotes Cervical Cancer Proliferation by Activating MAPK Signaling Pathway.
    3. SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma.
      Title: SEC61G identified as a prognostic biomarker of head and neck squamous cell carcinoma.
    4. SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma.
      Title: SEC61G overexpression and DNA amplification correlates with prognosis and immune cell infiltration in head and neck squamous cell carcinoma.
    5. Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation.
      Title: Prognostic value of SEC61G in lung adenocarcinoma: a comprehensive study based on bioinformatics and in vitro validation.
    6. SEC61G plays an oncogenic role in hepatocellular carcinoma cells.
      Title: SEC61G plays an oncogenic role in hepatocellular carcinoma cells.
    7. SEC61G is upregulated and required for tumor progression in human kidney cancer.
      Title: SEC61G is upregulated and required for tumor progression in human kidney cancer.
    8. SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.
      Title: SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.
    9. LncRNA LINC02418 regulates proliferation and apoptosis of non-small cell lung cancer cells by regulating miR-4677-3p/SEC61G.
      Title: LncRNA LINC02418 regulates proliferation and apoptosis of non-small cell lung cancer cells by regulating miR-4677-3p/SEC61G.
    10. High expression of SEC61G was significantly correlated with poor prognosis in all GBM patients. High expression of SEC61G was also associated with poor outcome.
      Title: Identification of SEC61G as a Novel Prognostic Marker for Predicting Survival and Response to Therapies in Patients with Glioblastoma.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    EBI GWAS Catalog
    GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of Sec61 gamma subunit (SEC61G) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to ER ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Ssh1 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein transport protein Sec61 subunit gamma
    Names
    SEC61 translocon gamma subunit
    Sec61 gamma subunit
    protein transport protein SEC61 gamma subunit

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012456.2 → NP_001012474.1  protein transport protein Sec61 subunit gamma

      See identical proteins and their annotated locations for NP_001012474.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF086539, BU932672, CD385140
      Consensus CDS
      CCDS5513.1
      UniProtKB/Swiss-Prot
      B2R4J0, P38384, P60059, Q6IB25
      Related
      ENSP00000378906.3, ENST00000395535.7
      Conserved Domains (1) summary
      cl00481
      Location:12 → 68
      SecE; SecE/Sec61-gamma subunits of protein translocation complex

    2. NM_014302.4 → NP_055117.1  protein transport protein Sec61 subunit gamma

      See identical proteins and their annotated locations for NP_055117.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF086539, BU932672, CD385140
      Consensus CDS
      CCDS5513.1
      UniProtKB/Swiss-Prot
      B2R4J0, P38384, P60059, Q6IB25
      Related
      ENSP00000341538.4, ENST00000352861.9
      Conserved Domains (1) summary
      cl00481
      Location:12 → 68
      SecE; SecE/Sec61-gamma subunits of protein translocation complex

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      54752253..54759211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      54912179..54919137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60059.1 GenPept UniProtKB/Swiss-Prot:P60059

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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