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    NMT2 N-myristoyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 9397, updated on 26-Nov-2024

    Summary

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    Official Symbol
    NMT2provided by HGNC
    Official Full Name
    N-myristoyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:7858
    See related
    Ensembl:ENSG00000152465 MIM:603801; AllianceGenome:HGNC:7858
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in fat (RPKM 9.3), testis (RPKM 5.5) and 24 other tissues See more
    Orthologs
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    Genomic context

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    See NMT2 in Genome Data Viewer
    Location:
    10p13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (15105700..15168693, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (15119744..15183186, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15147769..15210692, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:15138899-15139470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3091 Neighboring gene RPP38 divergent transcript Neighboring gene ribonuclease P/MRP subunit p38 Neighboring gene uncharacterized LOC105376431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3093 Neighboring gene uncharacterized LOC107984210 Neighboring gene peptidylprolyl isomerase A pseudogene 30 Neighboring gene MPRA-validated peak871 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2169 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene uncharacterized LOC105376434 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:15242369-15243568

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Is the disruption of an N-myristoyltransferase (NMT2) associated with hypoplastic testes? Quintero-Rivera F, et al. Am J Med Genet A, 2007 Aug 1. PMID 17568424
    2. Regulation of co- and post-translational myristoylation of proteins during apoptosis: interplay of N-myristoyltransferases and caspases. Perinpanayagam MA, et al. FASEB J, 2013 Feb. PMID 23150525
    3. Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2. Kolluri SK, et al. Cancer Res, 2001 Dec 1. PMID 11731439
    4. Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein. Geyer M, et al. J Mol Biol, 1999 May 28. PMID 10339411
    5. Quantitative fluorescence resonance energy transfer microscopy analysis of the human immunodeficiency virus type 1 Gag-Gag interaction: relative contributions of the CA and NC domains and membrane binding. Hogue IB, et al. J Virol, 2009 Jul. PMID 19403686, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-mytistoyltransferase 1 and 2 are potential tumor suppressors and novel targets of miR-182 in human non-small cell lung carcinomas.
      Title: N-mytistoyltransferase 1 and 2 are potential tumor suppressors and novel targets of miR-182 in human non-small cell lung carcinomas.
    2. ligand binding properties of the NMT/ACBD6 complex can explain how the NMT reaction can proceed in the presence of the very abundant competitive substrate, C(16)-CoA.
      Title: Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA.
    3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. Nef is preferentially myristoylated by NMT2, suggesting that selective inhibition of NMT2 may provide a novel means of blocking HIV virulence.
      Title: N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef.
    7. Disruption of the gene for NMT2 by a t(8;10) translocation in a male with hypogonadism.
      Title: Is the disruption of an N-myristoyltransferase (NMT2) associated with hypoplastic testes?
    8. Protein-protein interaction of NMTs revealed that m-calpain interacts with NMT1 while caspase-3 interacts with NMT2.
      Title: N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system.
    9. Involved in progression and regulation of telomerase
      Title: Genes associated with telomerase activity levels in esophageal carcinoma cell lines.
    10. induction of NMT2 may play a central role in dioxin carcinogenicity.
      Title: Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef The N-terminal methionine of HIV-1 Nef is myristoylated by N-myristoyltransferase PubMed
    matrix gag HIV-1 Matrix is myristoylated on its N-terminal glycine residue by N-myristoyltransferase, a chemical modification important for membrane targeting of Gag/Matrix, for facilitating Matrix multimerization, and for virus particle formation and budding PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables glycylpeptide N-tetradecanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycylpeptide N-tetradecanoyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables peptidyl-lysine N6-myristoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-glycine N-myristoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular transport of virus TAS
    Traceable Author Statement
    more info
    		  
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of opsin-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glycylpeptide N-tetradecanoyltransferase 2
    Names
    NMT 2
    myristoyl-CoA:protein N-myristoyltransferase 2
    peptide N-myristoyltransferase 2
    protein-lysine myristoyltransferase NMT2
    type II N-myristoyltransferase
    NP_001295224.1
    NP_004799.1
    XP_005252699.1
    XP_006717602.1
    XP_016872438.1
    XP_016872440.1
    XP_024304030.1
    XP_047281975.1
    XP_054223165.1
    XP_054223166.1
    XP_054223167.1
    XP_054223168.1
    XP_054223169.1
    XP_054223170.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308295.2 → NP_001295224.1  glycylpeptide N-tetradecanoyltransferase 2 isoform 2

      See identical proteins and their annotated locations for NP_001295224.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) includes an alternate exon which results in the use of an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF043325, AF086423, AK094904, AL590365, DB465189
      Consensus CDS
      CCDS76284.1
      UniProtKB/TrEMBL
      B3KT39, Q5VUC6
      Related
      ENSP00000367392.1, ENST00000378150.1
      Conserved Domains (1) summary
      cl27359
      Location:106 → 473
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    2. NM_004808.3 → NP_004799.1  glycylpeptide N-tetradecanoyltransferase 2 isoform 1

      See identical proteins and their annotated locations for NP_004799.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF043325, AL590365
      Consensus CDS
      CCDS7109.1
      UniProtKB/Swiss-Prot
      B0YJ49, O60551, Q53Y38, Q5VUC8, Q9BRB4
      UniProtKB/TrEMBL
      B2RCF3
      Related
      ENSP00000367407.3, ENST00000378165.9
      Conserved Domains (1) summary
      cl27359
      Location:119 → 486
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      15105700..15168693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426019.1 → XP_047281975.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X4

    2. XM_005252642.6 → XP_005252699.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

      UniProtKB/TrEMBL
      B2RCF3
      Conserved Domains (2) summary
      pfam01233
      Location:140 → 294
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:310 → 485
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    3. XM_017016949.3 → XP_016872438.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2

      UniProtKB/TrEMBL
      B3KT39

    4. XM_006717539.5 → XP_006717602.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X3

      UniProtKB/TrEMBL
      B2RCF3
      Conserved Domains (2) summary
      pfam01233
      Location:140 → 256
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:253 → 428
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    5. XM_017016951.3 → XP_016872440.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X5

      UniProtKB/TrEMBL
      B3KT39

    6. XM_024448262.2 → XP_024304030.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X6

      UniProtKB/TrEMBL
      B3KT39, B4DHU9
      Conserved Domains (1) summary
      cl27359
      Location:32 → 399
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      15119744..15183186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367192.1 → XP_054223167.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X3

    2. XM_054367194.1 → XP_054223169.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X5

    3. XM_054367195.1 → XP_054223170.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X6

    4. XM_054367193.1 → XP_054223168.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X4

    5. XM_054367190.1 → XP_054223165.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

    6. XM_054367191.1 → XP_054223166.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60551.1 GenPept UniProtKB/Swiss-Prot:O60551

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