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    CEP170 centrosomal protein 170 [ Homo sapiens (human) ]

    Gene ID: 9859, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CEP170provided by HGNC
    Official Full Name
    centrosomal protein 170provided by HGNC
    Primary source
    HGNC:HGNC:28920
    See related
    Ensembl:ENSG00000143702 MIM:613023; AllianceGenome:HGNC:28920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KAB; FAM68A; KIAA0470
    Summary
    The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 12.9), testis (RPKM 11.4) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CEP170 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (243124428..243255785, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (242535446..242666489, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (243287730..243418583, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1347 Neighboring gene uncharacterized LOC124904568 Neighboring gene RNA, U6 small nuclear 747, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:243277095-243277846 Neighboring gene NANOG hESC enhancer GRCh37_chr1:243285114-243285617 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:243337129-243337774 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:243338714-243339414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:243339415-243340113 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:243431137-243432336 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:243448123-243448859 Neighboring gene SHH signaling and ciliogenesis regulator SDCCAG8 Neighboring gene FCF1 pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 8354 Neighboring gene microRNA 4677

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. hVFL3/CCDC61 is a component of mother centriole subdistal appendages required for centrosome cohesion and positioning. Pizon V, et al. Biol Cell, 2020 Jan. PMID 31789463
    2. A SEPT1-based scaffold is required for Golgi integrity and function. Song K, et al. J Cell Sci, 2019 Feb 1. PMID 30709970, Free PMC Article
    3. The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle. Welburn JP, et al. Mol Biol Cell, 2012 Dec. PMID 23087211, Free PMC Article
    4. Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry. Bärenz F, et al. Mol Biol Cell, 2018 Dec 15. PMID 30354798, Free PMC Article
    5. The C-terminal region of A-kinase anchor protein 350 (AKAP350A) enables formation of microtubule-nucleation centers and interacts with pericentriolar proteins. Kolobova E, et al. J Biol Chem, 2017 Dec 15. PMID 29054927, Free PMC Article

    See all (166) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. alpha-/gamma-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
      Title: α-/γ-Taxilin are required for centriolar subdistal appendage assembly and microtubule organization.
    2. Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry.
      Title: Ccdc61 controls centrosomal localization of Cep170 and is required for spindle assembly and symmetry.
    3. SEPT1 function depends on the Golgi matrix protein GOLGA2 and on centrosomal proteins, including CEP170 and components of gamma-tubulin ring complex, to facilitate the perinuclear concentration of Golgi membranes.
      Title: A SEPT1-based scaffold is required for Golgi integrity and function.
    4. Study in mutant mice and human cerebral organoids showed that WDR62 deletion resulted in a reduction in the size of mouse brains and organoids due to the disruption of neural progenitor cells. WDR62 interacts with and promotes CEP170 localization to the basal body of primary cilium, where CEP170 recruits KIF2A to disassemble cilium.
      Title: Modeling microcephaly with cerebral organoids reveals a WDR62-CEP170-KIF2A pathway promoting cilium disassembly in neural progenitors.
    5. Data suggest that CDK5RAP2 and CEP170 both interact with microtubule nucleation-promoting region of AKAP350A; CEP68 interacts with distal C-terminal region of AKAP350A; AKAP350A spans the bridge between centrioles. (CDK5RAP2 = CDK5 regulatory subunit associated protein 2; CEP170 = centrosomal protein 170kDa; AKAP350A = A kinase (PRKA) anchor protein (yotiao) 9; CEP68 = centrosomal protein 68kDa)
      Title: The C-terminal region of A-kinase anchor protein 350 (AKAP350A) enables formation of microtubule-nucleation centers and interacts with pericentriolar proteins.
    6. Data indicate that Cep170 association with the C-terminus of Kif2b enhances localization of Kif2b to the spindle.
      Title: The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. Observational study of gene-disease association. (HuGE Navigator)
      Title: Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.
    9. Cep170 interacts with Polo-like kinase 1 in mature centrioles.
      Title: The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
    EBI GWAS Catalog
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV Vif interacts with CEP170 PubMed
    Vpr vpr HIV-1 Vpr is identified to have a physical interaction with centrosomal protein 170kDa (CEP170) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of centriolar subdistal appendage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 170 kDa
    Names
    KARP-1-binding protein
    XRCC5 binding protein
    centrosomal protein 170kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029663.2 RefSeqGene

      Range
      5126..135979
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042404.2 → NP_001035863.1  centrosomal protein of 170 kDa isoform beta

      See identical proteins and their annotated locations for NP_001035863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (beta, also known as 2) lacks an alternate in-frame exon, compared to variant alpha, resulting in a shorter protein (isoform beta), compared to isoform alpha.
      Source sequence(s)
      AB022658, AC092782, AL606534, BP349206, BP349680, CB410835
      Consensus CDS
      CCDS44337.1
      UniProtKB/TrEMBL
      B2RTS4
      Related
      ENSP00000355502.1, ENST00000366544.6
      Conserved Domains (3) summary
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:713 → 1408
      CEP170_C; CEP170 C-terminus

    2. NM_001042405.2 → NP_001035864.1  centrosomal protein of 170 kDa isoform gamma

      See identical proteins and their annotated locations for NP_001035864.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (gamma, also known as 3) has multiple differences in the coding region but maintains the reading frame, compared to variant alpha, resulting in a shorter protein (isoform gamma), compared to isoform alpha.
      Source sequence(s)
      AB022659, AC092782, BP349206, BP349680, CB410835
      Consensus CDS
      CCDS44338.1
      UniProtKB/TrEMBL
      A6H8X9
      Related
      ENSP00000355501.1, ENST00000366543.5
      Conserved Domains (3) summary
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:713 → 1382
      CEP170_C; CEP170 C-terminus

    3. NM_014812.3 → NP_055627.2  centrosomal protein of 170 kDa isoform alpha

      See identical proteins and their annotated locations for NP_055627.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (alpha, also known as 1) represents the longest transcript and encodes the longest isoform (alpha).
      Source sequence(s)
      AB022657, AC092782, AL606534, BP349206, BP349680, CB410835
      Consensus CDS
      CCDS44339.1
      UniProtKB/Swiss-Prot
      O75058, Q5SW77, Q5SW78, Q5SW79, Q7LGA9, Q86W31, Q9UQ08, Q9UQ09
      UniProtKB/TrEMBL
      B2RTS4
      Related
      ENSP00000355500.1, ENST00000366542.6
      Conserved Domains (4) summary
      pfam09528
      Location:353 → 854
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:811 → 1506
      CEP170_C; CEP170 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      243124428..243255785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435483.1 → XP_047291439.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    2. XM_006711843.5 → XP_006711906.1  centrosomal protein of 170 kDa isoform X1

      See identical proteins and their annotated locations for XP_006711906.1

      UniProtKB/TrEMBL
      H0Y2V6
      Related
      ENSP00000338161.4, ENST00000336415.8
      Conserved Domains (4) summary
      pfam09528
      Location:466 → 916
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:873 → 1578
      CEP170_C; CEP170 C-terminus

    3. XM_017002951.3 → XP_016858440.1  centrosomal protein of 170 kDa isoform X18

      UniProtKB/TrEMBL
      B2RTS4

    4. XM_017002946.3 → XP_016858435.1  centrosomal protein of 170 kDa isoform X16

      UniProtKB/TrEMBL
      B2RTS4

    5. XM_011544343.4 → XP_011542645.1  centrosomal protein of 170 kDa isoform X12

      See identical proteins and their annotated locations for XP_011542645.1

      UniProtKB/TrEMBL
      H0Y2V6
      Conserved Domains (4) summary
      pfam09528
      Location:307 → 757
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:714 → 1419
      CEP170_C; CEP170 C-terminus

    6. XM_017002949.3 → XP_016858438.1  centrosomal protein of 170 kDa isoform X17

      UniProtKB/TrEMBL
      A6H8X9

    7. XM_017002947.3 → XP_016858436.1  centrosomal protein of 170 kDa isoform X15

      UniProtKB/TrEMBL
      A6H8X9

    8. XM_017002945.3 → XP_016858434.1  centrosomal protein of 170 kDa isoform X14

      UniProtKB/TrEMBL
      B2RTS4

    9. XM_011544344.4 → XP_011542646.1  centrosomal protein of 170 kDa isoform X13

      See identical proteins and their annotated locations for XP_011542646.1

      UniProtKB/TrEMBL
      B2RTS4
      Conserved Domains (3) summary
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:713 → 1418
      CEP170_C; CEP170 C-terminus

    10. XM_017002942.3 → XP_016858431.1  centrosomal protein of 170 kDa isoform X11

      UniProtKB/TrEMBL
      A6H8X9

    11. XM_017002938.3 → XP_016858427.1  centrosomal protein of 170 kDa isoform X10

      UniProtKB/TrEMBL
      A6H8X9

    12. XM_017002937.3 → XP_016858426.1  centrosomal protein of 170 kDa isoform X9

      UniProtKB/TrEMBL
      A6H8X9

    13. XM_017002935.3 → XP_016858424.1  centrosomal protein of 170 kDa isoform X8

      UniProtKB/TrEMBL
      B2RTS4

    14. XM_011544341.4 → XP_011542643.1  centrosomal protein of 170 kDa isoform X6

      See identical proteins and their annotated locations for XP_011542643.1

      UniProtKB/TrEMBL
      B2RTS4
      Conserved Domains (4) summary
      pfam09528
      Location:353 → 854
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:811 → 1516
      CEP170_C; CEP170 C-terminus

    15. XM_011544342.4 → XP_011542644.1  centrosomal protein of 170 kDa isoform X7

      See identical proteins and their annotated locations for XP_011542644.1

      UniProtKB/TrEMBL
      H0Y2V6
      Conserved Domains (4) summary
      pfam09528
      Location:466 → 916
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:873 → 1515
      CEP170_C; CEP170 C-terminus

    16. XM_011544340.4 → XP_011542642.1  centrosomal protein of 170 kDa isoform X5

      See identical proteins and their annotated locations for XP_011542642.1

      UniProtKB/TrEMBL
      H0Y2V6
      Conserved Domains (4) summary
      pfam09528
      Location:466 → 916
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:873 → 1532
      CEP170_C; CEP170 C-terminus

    17. XM_011544339.4 → XP_011542641.1  centrosomal protein of 170 kDa isoform X4

      See identical proteins and their annotated locations for XP_011542641.1

      UniProtKB/TrEMBL
      H0Y2V6
      Conserved Domains (4) summary
      pfam09528
      Location:466 → 916
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:873 → 1542
      CEP170_C; CEP170 C-terminus

    18. XM_011544338.4 → XP_011542640.1  centrosomal protein of 170 kDa isoform X3

      See identical proteins and their annotated locations for XP_011542640.1

      UniProtKB/TrEMBL
      H0Y2V6
      Conserved Domains (4) summary
      pfam09528
      Location:466 → 916
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:873 → 1551
      CEP170_C; CEP170 C-terminus

    19. XM_011544337.4 → XP_011542639.1  centrosomal protein of 170 kDa isoform X2

      See identical proteins and their annotated locations for XP_011542639.1

      UniProtKB/TrEMBL
      H0Y2V6
      Conserved Domains (4) summary
      pfam09528
      Location:466 → 916
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:873 → 1568
      CEP170_C; CEP170 C-terminus

    20. XM_011544334.4 → XP_011542636.1  centrosomal protein of 170 kDa isoform X1

      See identical proteins and their annotated locations for XP_011542636.1

      UniProtKB/TrEMBL
      H0Y2V6
      Conserved Domains (4) summary
      pfam09528
      Location:466 → 916
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:873 → 1578
      CEP170_C; CEP170 C-terminus

    21. XM_011544335.4 → XP_011542637.1  centrosomal protein of 170 kDa isoform X1

      See identical proteins and their annotated locations for XP_011542637.1

      UniProtKB/TrEMBL
      H0Y2V6
      Conserved Domains (4) summary
      pfam09528
      Location:466 → 916
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:873 → 1578
      CEP170_C; CEP170 C-terminus

    22. XM_011544336.3 → XP_011542638.1  centrosomal protein of 170 kDa isoform X1

      See identical proteins and their annotated locations for XP_011542638.1

      UniProtKB/TrEMBL
      H0Y2V6
      Conserved Domains (4) summary
      pfam09528
      Location:466 → 916
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:873 → 1578
      CEP170_C; CEP170 C-terminus

    23. XM_017002932.2 → XP_016858421.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6
      Conserved Domains (4) summary
      pfam09528
      Location:466 → 916
      Ehrlichia_rpt; Ehrlichia tandem repeat (Ehrlichia_rpt)
      COG1716
      Location:12 → 90
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:5 → 98
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      pfam15308
      Location:873 → 1578
      CEP170_C; CEP170 C-terminus

    24. XM_047435495.1 → XP_047291451.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187519.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      136536..267572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328636.1 → XP_054184611.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    2. XM_054328633.1 → XP_054184608.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    3. XM_054328653.1 → XP_054184628.1  centrosomal protein of 170 kDa isoform X18

      UniProtKB/TrEMBL
      B2RTS4

    4. XM_054328651.1 → XP_054184626.1  centrosomal protein of 170 kDa isoform X16

      UniProtKB/TrEMBL
      B2RTS4

    5. XM_054328647.1 → XP_054184622.1  centrosomal protein of 170 kDa isoform X12

      UniProtKB/TrEMBL
      H0Y2V6

    6. XM_054328652.1 → XP_054184627.1  centrosomal protein of 170 kDa isoform X17

      UniProtKB/TrEMBL
      A6H8X9

    7. XM_054328650.1 → XP_054184625.1  centrosomal protein of 170 kDa isoform X15

      UniProtKB/TrEMBL
      A6H8X9

    8. XM_054328649.1 → XP_054184624.1  centrosomal protein of 170 kDa isoform X14

      UniProtKB/TrEMBL
      B2RTS4

    9. XM_054328648.1 → XP_054184623.1  centrosomal protein of 170 kDa isoform X13

      UniProtKB/TrEMBL
      B2RTS4

    10. XM_054328646.1 → XP_054184621.1  centrosomal protein of 170 kDa isoform X11

      UniProtKB/TrEMBL
      A6H8X9

    11. XM_054328645.1 → XP_054184620.1  centrosomal protein of 170 kDa isoform X10

      UniProtKB/TrEMBL
      A6H8X9

    12. XM_054328644.1 → XP_054184619.1  centrosomal protein of 170 kDa isoform X9

      UniProtKB/TrEMBL
      A6H8X9

    13. XM_054328643.1 → XP_054184618.1  centrosomal protein of 170 kDa isoform X8

      UniProtKB/TrEMBL
      B2RTS4

    14. XM_054328641.1 → XP_054184616.1  centrosomal protein of 170 kDa isoform X6

      UniProtKB/TrEMBL
      B2RTS4

    15. XM_054328642.1 → XP_054184617.1  centrosomal protein of 170 kDa isoform X7

      UniProtKB/TrEMBL
      H0Y2V6

    16. XM_054328640.1 → XP_054184615.1  centrosomal protein of 170 kDa isoform X5

      UniProtKB/TrEMBL
      H0Y2V6

    17. XM_054328639.1 → XP_054184614.1  centrosomal protein of 170 kDa isoform X4

      UniProtKB/TrEMBL
      H0Y2V6

    18. XM_054328638.1 → XP_054184613.1  centrosomal protein of 170 kDa isoform X3

      UniProtKB/TrEMBL
      H0Y2V6

    19. XM_054328637.1 → XP_054184612.1  centrosomal protein of 170 kDa isoform X2

      UniProtKB/TrEMBL
      H0Y2V6

    20. XM_054328631.1 → XP_054184606.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    21. XM_054328632.1 → XP_054184607.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    22. XM_054328634.1 → XP_054184609.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    23. XM_054328635.1 → XP_054184610.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      242535446..242666489 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339854.1 → XP_054195829.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    2. XM_054339851.1 → XP_054195826.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    3. XM_054339871.1 → XP_054195846.1  centrosomal protein of 170 kDa isoform X18

      UniProtKB/TrEMBL
      B2RTS4

    4. XM_054339869.1 → XP_054195844.1  centrosomal protein of 170 kDa isoform X16

      UniProtKB/TrEMBL
      B2RTS4

    5. XM_054339865.1 → XP_054195840.1  centrosomal protein of 170 kDa isoform X12

      UniProtKB/TrEMBL
      H0Y2V6

    6. XM_054339870.1 → XP_054195845.1  centrosomal protein of 170 kDa isoform X17

      UniProtKB/TrEMBL
      A6H8X9

    7. XM_054339868.1 → XP_054195843.1  centrosomal protein of 170 kDa isoform X15

      UniProtKB/TrEMBL
      A6H8X9

    8. XM_054339867.1 → XP_054195842.1  centrosomal protein of 170 kDa isoform X14

      UniProtKB/TrEMBL
      B2RTS4

    9. XM_054339866.1 → XP_054195841.1  centrosomal protein of 170 kDa isoform X13

      UniProtKB/TrEMBL
      B2RTS4

    10. XM_054339864.1 → XP_054195839.1  centrosomal protein of 170 kDa isoform X11

      UniProtKB/TrEMBL
      A6H8X9

    11. XM_054339863.1 → XP_054195838.1  centrosomal protein of 170 kDa isoform X10

      UniProtKB/TrEMBL
      A6H8X9

    12. XM_054339862.1 → XP_054195837.1  centrosomal protein of 170 kDa isoform X9

      UniProtKB/TrEMBL
      A6H8X9

    13. XM_054339861.1 → XP_054195836.1  centrosomal protein of 170 kDa isoform X8

      UniProtKB/TrEMBL
      B2RTS4

    14. XM_054339859.1 → XP_054195834.1  centrosomal protein of 170 kDa isoform X6

      UniProtKB/TrEMBL
      B2RTS4

    15. XM_054339860.1 → XP_054195835.1  centrosomal protein of 170 kDa isoform X7

      UniProtKB/TrEMBL
      H0Y2V6

    16. XM_054339858.1 → XP_054195833.1  centrosomal protein of 170 kDa isoform X5

      UniProtKB/TrEMBL
      H0Y2V6

    17. XM_054339857.1 → XP_054195832.1  centrosomal protein of 170 kDa isoform X4

      UniProtKB/TrEMBL
      H0Y2V6

    18. XM_054339856.1 → XP_054195831.1  centrosomal protein of 170 kDa isoform X3

      UniProtKB/TrEMBL
      H0Y2V6

    19. XM_054339855.1 → XP_054195830.1  centrosomal protein of 170 kDa isoform X2

      UniProtKB/TrEMBL
      H0Y2V6

    20. XM_054339849.1 → XP_054195824.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    21. XM_054339850.1 → XP_054195825.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    22. XM_054339852.1 → XP_054195827.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6

    23. XM_054339853.1 → XP_054195828.1  centrosomal protein of 170 kDa isoform X1

      UniProtKB/TrEMBL
      H0Y2V6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5SW79.1 GenPept UniProtKB/Swiss-Prot:Q5SW79

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