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    HAR1B highly accelerated region 1B [ Homo sapiens (human) ]

    Gene ID: 768097, updated on 17-Sep-2024

    Summary

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    Official Symbol
    HAR1Bprovided by HGNC
    Official Full Name
    highly accelerated region 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:33118
    See related
    Ensembl:ENSG00000231133 MIM:610557; AllianceGenome:HGNC:33118
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HAR1R; LINC00065; NCRNA00065
    Expression
    Biased expression in testis (RPKM 2.6), brain (RPKM 0.9) and 6 other tissues See more
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    Genomic context

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    See HAR1B in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (63095493..63102319, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64897543..64904921, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61726845..61733671, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1056 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61687794-61687994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61690954-61691796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61691797-61692638 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61699516-61700022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61700597-61701098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61701099-61701598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13145 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61704121-61704620 Neighboring gene long intergenic non-protein coding RNA 1749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13146 Neighboring gene highly accelerated region 1A Neighboring gene uncharacterized LOC105372719 Neighboring gene MPRA-validated peak4307 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr20:61751164-61751347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:61753175-61753676 Neighboring gene uncharacterized LOC105376996

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The expression profile of HAR1A and HAR1B in the peripheral blood cells of multiple sclerosis patients. Akbarzadeh S, et al. Mol Biol Rep, 2023 Mar. PMID 36583781
    2. Expression profiling of cancer-related long non-coding RNAs revealed upregulation and biomarker potential of HAR1B and JPX in colorectal cancer. Khajehdehi M, et al. Mol Biol Rep, 2022 Jul. PMID 35526243
    3. An RNA gene expressed during cortical development evolved rapidly in humans. Pollard KS, et al. Nature, 2006 Sep 14. PMID 16915236
    4. lncRNAdb: a reference database for long noncoding RNAs. Amaral PP, et al. Nucleic Acids Res, 2011 Jan. PMID 21112873, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The expression profile of HAR1A and HAR1B in the peripheral blood cells of multiple sclerosis patients.
      Title: The expression profile of HAR1A and HAR1B in the peripheral blood cells of multiple sclerosis patients.
    2. Expression profiling of cancer-related long non-coding RNAs revealed upregulation and biomarker potential of HAR1B and JPX in colorectal cancer.
      Title: Expression profiling of cancer-related long non-coding RNAs revealed upregulation and biomarker potential of HAR1B and JPX in colorectal cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    General gene information

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    Other Names

    • highly accelerated region 1B (non-protein coding)
    • highly accelerated region 1B (non-protein-coding RNA)
    • human accelerated region 1, reverse
    • long intergenic non-protein coding RNA 65

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003245.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      DQ860410
      Related
      ENST00000447910.2

    2. NR_152601.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      DQ860411
      Related
      ENST00000608031.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      63095493..63102319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      64897543..64904921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials