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    AATBC apoptosis associated transcript in bladder cancer [ Homo sapiens (human) ]

    Gene ID: 284837, updated on 17-Sep-2024

    Summary

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    Official Symbol
    AATBCprovided by HGNC
    Official Full Name
    apoptosis associated transcript in bladder cancerprovided by HGNC
    Primary source
    HGNC:HGNC:51526
    See related
    Ensembl:ENSG00000215458 AllianceGenome:HGNC:51526
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in skin (RPKM 2.8), urinary bladder (RPKM 1.3) and 13 other tissues See more
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    Genomic context

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    See AATBC in Genome Data Viewer
    Location:
    21q22.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (43805758..43812567, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (42161368..42168177, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (45225639..45232448, complement)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45206281-45206822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45206823-45207363 Neighboring gene transmembrane protein 97 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13370 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:45211808-45212020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45213337-45213836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45213839-45214490 Neighboring gene ribosomal RNA processing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18549 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:45230034-45230950 Neighboring gene uncharacterized LOC124905033 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:45269891-45270437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18552 Neighboring gene MYL6 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA AATBC indicates development and facilitates cell growth and metastasis of cervical cancer as a sponge of miR-1245b-5p. Liu YQ, et al. Kaohsiung J Med Sci, 2023 Feb. PMID 36420764
    2. LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma. Tang T, et al. Mol Oncol, 2020 Sep. PMID 32364663, Free PMC Article
    3. Knockdown of a novel lincRNA AATBC suppresses proliferation and induces apoptosis in bladder cancer. Zhao F, et al. Oncotarget, 2015 Jan 20. PMID 25473900, Free PMC Article
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA AATBC indicates development and facilitates cell growth and metastasis of cervical cancer as a sponge of miR-1245b-5p.
      Title: LncRNA AATBC indicates development and facilitates cell growth and metastasis of cervical cancer as a sponge of miR-1245b-5p.
    2. LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma.
      Title: LncRNA AATBC regulates Pinin to promote metastasis in nasopharyngeal carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Clone Names

    • MGC133248, AP001053.11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_026961.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK128598, AP001053, BC031911, BC034348
      Related
      ENST00000400385.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      43805758..43812567 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      42161368..42168177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_194310.1: Suppressed sequence

      Description
      NM_194310.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZR03.1 GenPept UniProtKB/Swiss-Prot:Q6ZR03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.