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    EEF1G eukaryotic translation elongation factor 1 gamma [ Homo sapiens (human) ]

    Gene ID: 1937, updated on 10-Dec-2024

    Summary

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    Official Symbol
    EEF1Gprovided by HGNC
    Official Full Name
    eukaryotic translation elongation factor 1 gammaprovided by HGNC
    Primary source
    HGNC:HGNC:3213
    See related
    Ensembl:ENSG00000254772 MIM:130593; AllianceGenome:HGNC:3213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EF1G; GIG35
    Summary
    This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 1189.4), lymph node (RPKM 694.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EEF1G in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62559596..62573891, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62549046..62563344, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62327068..62341363, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62193633-62194180 Neighboring gene secretoglobin family 1A member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62201545-62202046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62202047-62202546 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4817 Neighboring gene Sharpr-MPRA regulatory region 7741 Neighboring gene AHNAK nucleoprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62273135-62273882 Neighboring gene Sharpr-MPRA regulatory region 266 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:62302796-62303995 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62306574-62307176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62307177-62307777 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4818 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4819 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62312785-62313295 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62313296-62313806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62314385-62314915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3415 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62318643-62319448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62319449-62320254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62323477-62324282 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62324283-62325086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62325319-62325834 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62326954-62327496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4824 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62329123-62329665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4825 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62341487-62342448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62342449-62343410 Neighboring gene microRNA 6747 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62358805-62359500 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4828 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62368208-62368918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3419 Neighboring gene metastasis associated 1 family member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. 1H, 15N and 13C resonance assignments of the highly conserved 19 kDa C-terminal domain from human elongation factor 1Bgamma. Vanwetswinkel S, et al. J Biomol NMR, 2003 Jun. PMID 12766415
    2. Expression of elongation factor-1 gamma-related sequence in human pancreatic cancer. Lew Y, et al. Pancreas, 1992. PMID 1372736
    3. Elongation factor-1 messenger-RNA levels in cultured cells are high compared to tissue and are not drastically affected further by oncogenic transformation. Sanders J, et al. Nucleic Acids Res, 1992 Nov 25. PMID 1461723, Free PMC Article
    4. Eukaryotic translation elongation factor 1 gamma contains a glutathione transferase domain--study of a diverse, ancient protein superfamily using motif search and structural modeling. Koonin EV, et al. Protein Sci, 1994 Nov. PMID 7703850, Free PMC Article
    5. Novel ALK fusion in anaplastic large cell lymphoma involving EEF1G, a subunit of the eukaryotic elongation factor-1 complex. Palacios G, et al. Leukemia, 2017 Mar. PMID 27840423, Free PMC Article

    See all (288) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study describes a novel EEF1G-ALK gene fusion in 2 pediatric patients with anaplastic large cell lymphoma that is associated with a cytoplasmic-restricted localization of the ALK fusion protein
      Title: Novel ALK fusion in anaplastic large cell lymphoma involving EEF1G, a subunit of the eukaryotic elongation factor-1 complex.
    2. Results show that eEF1Bgamma binds not only Che-1 and p53 transcripts but also their promoters. Its depletion significantly decreases p53 protein accumulation and slightly impacts on Che-1 accumulation in the mitochondria. These data support the notion that eEF1Bgamma, besides its canonical role in translation, is an RNA-binding protein and a key player in cellular stress responses.
      Title: eEF1Bγ binds the Che-1 and TP53 gene promoters and their transcripts.
    3. eEF1gamma, in addition to its role in translation elongation complex, is involved in regulating Vimentin gene by contacting both pol II and the Vimentin promoter region and shuttling/nursing the Vimentin mRNA
      Title: The eEF1γ subunit contacts RNA polymerase II and binds vimentin promoter region.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein translational elongation factor 1 PubMed
    nef Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 gamma (EEF1G), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    integrase gag-pol HIV-1 IN co-immunoprecipitates with eEF1G through an interaction with the viral RTCs PubMed
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human eukaryotic translation elongation factor 1 gamma (EEF1G) at amino acid residues 20-21 by the HIV-1 protease PubMed
    reverse transcriptase p51 subunit gag-pol HIV-1 RT p51 subunit co-immunoprecipitates with eEF1A through an interaction with the viral RTCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to virus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in membrane HDA PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    elongation factor 1-gamma
    Names
    EF-1-gamma
    PRO1608
    eEF-1B gamma
    pancreatic tumor-related protein
    translation elongation factor eEF-1 gamma chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001404.5 → NP_001395.1  elongation factor 1-gamma

      See identical proteins and their annotated locations for NP_001395.1

      Status: REVIEWED

      Source sequence(s)
      AP001363, BC028179, BQ947806, X63526
      Consensus CDS
      CCDS44626.1
      UniProtKB/Swiss-Prot
      B4DTG2, P26641, Q6PJ62, Q6PK31, Q96CU2, Q9P196
      UniProtKB/TrEMBL
      Q53YD7
      Related
      ENSP00000331901.4, ENST00000329251.5
      Conserved Domains (4) summary
      cd03181
      Location:91 → 213
      GST_C_EF1Bgamma_like; Glutathione S-transferase C-terminal-like, alpha helical domain of the Gamma subunit of Elongation Factor 1B and similar proteins
      PRK09510
      Location:212 → 278
      tolA; cell envelope integrity inner membrane protein TolA; Provisional
      cd03044
      Location:4 → 82
      GST_N_EF1Bgamma; GST_N family, Gamma subunit of Elongation Factor 1B (EFB1gamma) subfamily; EF1Bgamma is part of the eukaryotic translation elongation factor-1 (EF1) complex which plays a central role in the elongation cycle during protein biosynthesis. EF1 consists of ...
      pfam00647
      Location:277 → 381
      EF1G; Elongation factor 1 gamma, conserved domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62559596..62573891 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62549046..62563344 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P26641.3 GenPept UniProtKB/Swiss-Prot:P26641

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