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    IQCM IQ motif containing M [ Homo sapiens (human) ]

    Gene ID: 285423, updated on 17-Sep-2024

    Summary

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    Official Symbol
    IQCMprovided by HGNC
    Official Full Name
    IQ motif containing Mprovided by HGNC
    Primary source
    HGNC:HGNC:53443
    See related
    Ensembl:ENSG00000234828 AllianceGenome:HGNC:53443
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Restricted expression toward testis (RPKM 3.1) See more
    Orthologs
    mouse all
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    Genomic context

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    See IQCM in Genome Data Viewer
    Location:
    4q31.23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (149351709..149815843, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (152673312..153137484, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (150272861..150736995, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2430 Neighboring gene NANOG hESC enhancer GRCh37_chr4:150104754-150105266 Neighboring gene long intergenic non-protein coding RNA 2355 Neighboring gene uncharacterized LOC107986320 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr4:150262096-150263295 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr4:150329764-150330963 Neighboring gene uncharacterized LOC105377479 Neighboring gene akirin 2 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:150769633-150770246 Neighboring gene RNA, U6 small nuclear 1230, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 167

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Novel associations for hypothyroidism include known autoimmune risk loci. Eriksson N, et al. PLoS One, 2012. PMID 22493691, Free PMC Article
    2. Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity. Kim JJ, et al. Genes Dev, 2019 Dec 1. PMID 31753913, Free PMC Article
    3. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Capalbo L, et al. Nat Commun, 2019 Oct 4. PMID 31586073, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Novel associations for hypothyroidism include known autoimmune risk loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    IQ domain-containing protein M
    Names
    iQ domain-containing protein M

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363507.2 → NP_001350436.1  IQ domain-containing protein M isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC027058, AC093893, AC096756, AC097465, AC108168
      Consensus CDS
      CCDS87270.1
      UniProtKB/Swiss-Prot
      A0A1B0GVH7
      Related
      ENSP00000490518.1, ENST00000636793.2

    2. NM_001363509.2 → NP_001350438.1  IQ domain-containing protein M isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC027058, AC093893, AC096756, AC108168
      Consensus CDS
      CCDS87271.1
      UniProtKB/TrEMBL
      A0A1B0GUF7
      Related
      ENSP00000490088.1, ENST00000636414.1

    3. NM_001378177.1 → NP_001365106.1  IQ domain-containing protein M isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC027058, AC093893, AC096756, AC108168

    4. NM_001378178.1 → NP_001365107.1  IQ domain-containing protein M isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC027058, AC093893, AC096756, AC108168

    5. NM_001378179.1 → NP_001365108.1  IQ domain-containing protein M isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC027058, AC093893, AC096756, AC108168
      Consensus CDS
      CCDS87271.1
      UniProtKB/TrEMBL
      A0A1B0GUF7

    6. NM_001378180.1 → NP_001365109.1  IQ domain-containing protein M isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC027058, AC093893, AC096756, AC097465, AC108168

    7. NM_001378181.1 → NP_001365110.1  IQ domain-containing protein M isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC027058, AC093893, AC096756, AC108168
      Conserved Domains (1) summary
      smart00015
      Location:153 → 175
      IQ; Calmodulin-binding motif

    8. NM_001378182.1 → NP_001365111.1  IQ domain-containing protein M isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC027058, AC093893, AC096756, AC108168
      Conserved Domains (1) summary
      smart00015
      Location:153 → 175
      IQ; Calmodulin-binding motif

    9. NM_001378184.1 → NP_001365113.1  IQ domain-containing protein M isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC027058, AC093893, AC096756, AC108168
      Conserved Domains (1) summary
      smart00015
      Location:140 → 162
      IQ; Calmodulin-binding motif

    10. NM_001378185.1 → NP_001365114.1  IQ domain-containing protein M isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC093893, AC096756
      UniProtKB/TrEMBL
      A0A1B0GVS1
      Related
      ENSP00000490631.1, ENST00000511993.5

    11. NM_001378186.1 → NP_001365115.1  IQ domain-containing protein M isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC093893, AC096756
      UniProtKB/TrEMBL
      A0A1B0GVS1

    12. NM_001378187.1 → NP_001365116.1  IQ domain-containing protein M isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC093893, AC096756
      UniProtKB/TrEMBL
      A0A1B0GVS1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      149351709..149815843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008904.3 → XP_016864393.1  IQ domain-containing protein M isoform X4

    2. XM_017008902.3 → XP_016864391.1  IQ domain-containing protein M isoform X1

    3. XM_017008903.3 → XP_016864392.1  IQ domain-containing protein M isoform X2

      UniProtKB/Swiss-Prot
      A0A1B0GVH7

    4. XM_017008900.3 → XP_016864389.1  IQ domain-containing protein M isoform X1

    5. XM_017008901.3 → XP_016864390.1  IQ domain-containing protein M isoform X1

    6. XM_047450076.1 → XP_047306032.1  IQ domain-containing protein M isoform X5

    7. XM_011532456.4 → XP_011530758.1  IQ domain-containing protein M isoform X3

      See identical proteins and their annotated locations for XP_011530758.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      152673312..153137484 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349708.1 → XP_054205683.1  IQ domain-containing protein M isoform X4

    2. XM_054349704.1 → XP_054205679.1  IQ domain-containing protein M isoform X1

    3. XM_054349706.1 → XP_054205681.1  IQ domain-containing protein M isoform X2

      UniProtKB/Swiss-Prot
      A0A1B0GVH7

    4. XM_054349703.1 → XP_054205678.1  IQ domain-containing protein M isoform X1

    5. XM_054349705.1 → XP_054205680.1  IQ domain-containing protein M isoform X1

    6. XM_054349709.1 → XP_054205684.1  IQ domain-containing protein M isoform X5

    7. XM_054349707.1 → XP_054205682.1  IQ domain-containing protein M isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A1B0GVH7.1 GenPept UniProtKB/Swiss-Prot:A0A1B0GVH7

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