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    NR0B2 nuclear receptor subfamily 0 group B member 2 [ Homo sapiens (human) ]

    Gene ID: 8431, updated on 27-Nov-2024

    Summary

    Official Symbol
    NR0B2provided by HGNC
    Official Full Name
    nuclear receptor subfamily 0 group B member 2provided by HGNC
    Primary source
    HGNC:HGNC:7961
    See related
    Ensembl:ENSG00000131910 MIM:604630; AllianceGenome:HGNC:7961
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SHP; SHP1
    Summary
    The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 26.3), liver (RPKM 15.9) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NR0B2 in Genome Data Viewer
    Location:
    1p36.11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26911489..26913975, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (26749548..26752039, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27237980..27240466, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene GPN-loop GTPase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27215935-27216812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 529 Neighboring gene G-patch domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 530 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27232113-27232613 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27232651-27233152 Neighboring gene nuclear distribution C, dynein complex regulator Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27241933-27242433 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27245085-27245285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 531 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27248501-27249042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 498 Neighboring gene Sharpr-MPRA regulatory region 10310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27286397-27287079 Neighboring gene keratinocyte differentiation factor 1 Neighboring gene Sharpr-MPRA regulatory region 5798 Neighboring gene negCOR silencer S3 Neighboring gene ribosomal protein L12 pseudogene 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Inherited obesity
    MedGen: C4054476 OMIM: 601665 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of nuclear receptor subfamily 0, group B, member 2 (NR0B2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ17090

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables nuclear retinoid X receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear thyroid hormone receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxisome proliferator activated receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transcription regulator inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bile acid and bile salt transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in circadian rhythm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucose IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nuclear receptor subfamily 0 group B member 2
    Names
    nuclear receptor SHP
    orphan nuclear receptor SHP
    small heterodimer partner

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012143.1 RefSeqGene

      Range
      5102..7588
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_021969.3NP_068804.1  nuclear receptor subfamily 0 group B member 2

      See identical proteins and their annotated locations for NP_068804.1

      Status: REVIEWED

      Source sequence(s)
      AI457167, BC030207
      Consensus CDS
      CCDS291.1
      UniProtKB/Swiss-Prot
      F1D8P5, Q15466, Q5QP36
      Related
      ENSP00000254227.3, ENST00000254227.4
      Conserved Domains (1) summary
      cd07349
      Location:32254
      NR_LBD_SHP; The ligand binding domain of DAX1 protein, a nuclear receptor lacking DNA binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      26911489..26913975 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011542297.4XP_011540599.1  nuclear receptor subfamily 0 group B member 2 isoform X1

      Conserved Domains (1) summary
      cl11397
      Location:32178
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      26749548..26752039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339184.1XP_054195159.1  nuclear receptor subfamily 0 group B member 2 isoform X1