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    MMP26 matrix metallopeptidase 26 [ Homo sapiens (human) ]

    Gene ID: 56547, updated on 27-Nov-2024

    Summary

    Official Symbol
    MMP26provided by HGNC
    Official Full Name
    matrix metallopeptidase 26provided by HGNC
    Primary source
    HGNC:HGNC:14249
    See related
    Ensembl:ENSG00000167346 MIM:605470; AllianceGenome:HGNC:14249
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016]
    Expression
    Restricted expression toward endometrium (RPKM 7.9) See more
    Orthologs
    NEW
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    Genomic context

    See MMP26 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (4704784..4992429)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (4770289..5049368)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (4726014..5013659)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376528 Neighboring gene olfactory receptor family 51 subfamily E member 2 Neighboring gene olfactory receptor family 51 subfamily C member 1 Neighboring gene olfactory receptor family 51 subfamily F member 5 pseudogene Neighboring gene olfactory receptor family 51 subfamily C member 4 pseudogene Neighboring gene keratin 8 pseudogene 49 Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene olfactory receptor family 51 subfamily F member 3 pseudogene Neighboring gene olfactory receptor family 51 subfamily F member 4 pseudogene Neighboring gene olfactory receptor family 51 subfamily F member 1 Neighboring gene olfactory receptor family 51 subfamily N member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily Y member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily R member 1 Neighboring gene olfactory receptor family 51 subfamily F member 2 Neighboring gene olfactory receptor family 51 subfamily A member 8 pseudogene Neighboring gene olfactory receptor family 51 subfamily S member 1 Neighboring gene olfactory receptor family 51 subfamily H member 1 Neighboring gene olfactory receptor family 51 subfamily H member 2 pseudogene Neighboring gene olfactory receptor family 51 subfamily T member 1 Neighboring gene olfactory receptor family 51 subfamily A member 6 pseudogene Neighboring gene olfactory receptor family 51 subfamily A member 7 Neighboring gene olfactory receptor family 51 subfamily G member 2 Neighboring gene olfactory receptor family 51 subfamily G member 1 Neighboring gene olfactory receptor family 51 subfamily A member 3 pseudogene Neighboring gene olfactory receptor family 51 subfamily A member 4 Neighboring gene olfactory receptor family 51 subfamily A member 2 Neighboring gene olfactory receptor family 51 subfamily A member 5 pseudogene Neighboring gene olfactory receptor family 51 subfamily L member 1 Neighboring gene olfactory receptor family 51 subfamily P member 1 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126590, MGC126592

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    matrix metalloproteinase-26
    Names
    MMP-26
    endometase
    matrilysin 2
    NP_001371537.1
    NP_068573.2
    XP_011518521.1
    XP_054225330.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001384608.1NP_001371537.1  matrix metalloproteinase-26 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC018375, AC090719, AC103710
      Consensus CDS
      CCDS91424.1
      UniProtKB/TrEMBL
      A0A8J8YUH5
      Related
      ENSP00000300762.2, ENST00000300762.2
      Conserved Domains (1) summary
      pfam00413
      Location:28183
      Peptidase_M10; Matrixin
    2. NM_021801.5NP_068573.2  matrix metalloproteinase-26 isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_068573.2

      Status: REVIEWED

      Source sequence(s)
      AC018375, AC090719, AC103710
      Consensus CDS
      CCDS7752.1
      UniProtKB/Swiss-Prot
      Q3MJ78, Q9GZS2, Q9NR87, Q9NRE1
      Related
      ENSP00000369753.1, ENST00000380390.6
      Conserved Domains (1) summary
      pfam00413
      Location:98253
      Peptidase_M10; Matrixin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      4704784..4992429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011520219.3XP_011518521.1  matrix metalloproteinase-26 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YUH5
      Conserved Domains (1) summary
      pfam00413
      Location:28183
      Peptidase_M10; Matrixin

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      4770289..5049368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369355.1XP_054225330.1  matrix metalloproteinase-26 isoform X1

      UniProtKB/TrEMBL
      A0A8J8YUH5