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    TNS4 tensin 4 [ Homo sapiens (human) ]

    Gene ID: 84951, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TNS4provided by HGNC
    Official Full Name
    tensin 4provided by HGNC
    Primary source
    HGNC:HGNC:24352
    See related
    Ensembl:ENSG00000131746 MIM:608385; AllianceGenome:HGNC:24352
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CTEN; PP14434
    Summary
    Predicted to enable actin binding activity. Involved in protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in skin (RPKM 23.1), esophagus (RPKM 12.4) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TNS4 in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (40475834..40501623, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (41339341..41365145, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38632086..38657875, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12146 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8491 Neighboring gene ribosomal protein L23a pseudogene 75 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8492 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8493 Neighboring gene insulin like growth factor binding protein 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38627029-38627920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38627921-38628810 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:38636369-38637568 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:38637551-38637736 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38646739-38647364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38649729-38650230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:38650231-38650730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:38655417-38656288 Neighboring gene uncharacterized LOC105371773 Neighboring gene Sharpr-MPRA regulatory region 2600 Neighboring gene uncharacterized LOC107985090

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Epigenetic Activation of Tensin 4 Promotes Gastric Cancer Progression. Heo H, et al. Mol Cells, 2023 May 31. PMID 36896596, Free PMC Article
    2. Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer. Lo SH, et al. Cancer Res, 2002 Aug 1. PMID 12154022
    3. Cten mRNA expression was correlated with tumor progression in lung cancers. Sasaki H, et al. Lung Cancer, 2003 May. PMID 12711115
    4. Tensins: a new switch in cell migration. Mouneimne G, et al. Dev Cell, 2007 Sep. PMID 17765673
    5. Prognostic relevance of Tensin4 expression in human gastric cancer. Sakashita K, et al. Ann Surg Oncol, 2008 Sep. PMID 18612693

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway.
      Title: GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway.
    2. Epigenetic Activation of Tensin 4 Promotes Gastric Cancer Progression.
      Title: Epigenetic Activation of Tensin 4 Promotes Gastric Cancer Progression.
    3. Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27.
      Title: Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27.
    4. Mining TCGA and GEO databases for the prediction of poor prognosis in lung adenocarcinoma based on up-regulated expression of TNS4.
      Title: Mining TCGA and GEO databases for the prediction of poor prognosis in lung adenocarcinoma based on up-regulated expression of TNS4.
    5. CTEN Inhibits Tumor Angiogenesis and Growth by Targeting VEGFA Through Down-Regulation of beta-Catenin in Breast Cancer.
      Title: CTEN Inhibits Tumor Angiogenesis and Growth by Targeting VEGFA Through Down-Regulation of β-Catenin in Breast Cancer.
    6. Investigating TNS4 in the Colorectal Tumor Microenvironment Using 3D Spheroid Models of Invasion.
      Title: Investigating TNS4 in the Colorectal Tumor Microenvironment Using 3D Spheroid Models of Invasion.
    7. Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells.
      Title: Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells.
    8. Tensin4 promotes invasion and migration of gastric cancer cells via regulating AKT/GSK-3beta/snail signaling pathway.
      Title: Tensin4 promotes invasion and migration of gastric cancer cells via regulating AKT/GSK-3β/snail signaling pathway.
    9. The authors propose that TNS4 plays a crucial role in CRC tumorigenesis, and that suppression of TNS4 would be an effective therapeutic strategy in treating a subset of cetuximab-refractory CRC patients including KRAS activating mutations.
      Title: Whole Transcriptome Analysis Identifies TNS4 as a Key Effector of Cetuximab and a Regulator of the Oncogenic Activity of KRAS Mutant Colorectal Cancer Cell Lines.
    10. analysis of cten force-induced recruitment along keratin network in epithelial cells
      Title: Force-induced recruitment of cten along keratin network in epithelial cells.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14950

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tensin-4
    Names
    C terminal tensin like
    C-terminal tensin-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032865.6 → NP_116254.4  tensin-4 precursor

      See identical proteins and their annotated locations for NP_116254.4

      Status: VALIDATED

      Source sequence(s)
      AC018629, AF417488, AW378527, AW937802, BC018706, BM710196
      Consensus CDS
      CCDS11368.1
      UniProtKB/Swiss-Prot
      A6NMJ7, Q71RB7, Q8IZW8, Q8WV64, Q96JV4
      UniProtKB/TrEMBL
      A0A2Z4HJF2
      Related
      ENSP00000254051.6, ENST00000254051.11
      Conserved Domains (2) summary
      cd01213
      Location:580 → 710
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cl15255
      Location:445 → 558
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      40475834..40501623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257744.2 → XP_005257801.1  tensin-4 isoform X2

      UniProtKB/TrEMBL
      A0A2Z4HJF2
      Conserved Domains (2) summary
      cd01213
      Location:579 → 709
      PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
      cl15255
      Location:444 → 557
      SH2; Src homology 2 (SH2) domain

    2. XM_017025236.2 → XP_016880725.1  tensin-4 isoform X3

      UniProtKB/TrEMBL
      A0A2Z4HJF2

    3. XM_047436949.1 → XP_047292905.1  tensin-4 isoform X1

    4. XM_047436950.1 → XP_047292906.1  tensin-4 isoform X5

    5. XM_017025237.2 → XP_016880726.1  tensin-4 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      41339341..41365145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317591.1 → XP_054173566.1  tensin-4 isoform X2

    2. XM_054317592.1 → XP_054173567.1  tensin-4 isoform X3

    3. XM_054317590.1 → XP_054173565.1  tensin-4 isoform X1

    4. XM_054317595.1 → XP_054173570.1  tensin-4 isoform X6

    5. XM_054317594.1 → XP_054173569.1  tensin-4 isoform X5

    6. XM_054317593.1 → XP_054173568.1  tensin-4 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZW8.3 GenPept UniProtKB/Swiss-Prot:Q8IZW8

    Gene LinkOut

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