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    MARCHF10 membrane associated ring-CH-type finger 10 [ Homo sapiens (human) ]

    Gene ID: 162333, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MARCHF10provided by HGNC
    Official Full Name
    membrane associated ring-CH-type finger 10provided by HGNC
    Primary source
    HGNC:HGNC:26655
    See related
    Ensembl:ENSG00000173838 MIM:613337; AllianceGenome:HGNC:26655
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF190; MARCH-X; MARCH10
    Summary
    MARCH10 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]
    Expression
    Restricted expression toward testis (RPKM 20.7) See more
    Orthologs
    mouse all
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    Genomic context

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    See MARCHF10 in Genome Data Viewer
    Location:
    17q23.2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (62701314..62808314, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (63571227..63678377, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (60778675..60885675, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985020 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8809 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8810 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60707912-60708768 Neighboring gene mannose receptor C-type 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729214-60729925 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60729926-60730636 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60731349-60732059 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60743431-60744021 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60746820-60747579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60747580-60748338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60748658-60749158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60749159-60749659 Neighboring gene Sharpr-MPRA regulatory region 5505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60757143-60757871 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60769301-60769962 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60769963-60770624 Neighboring gene RNA, U6 small nuclear 446, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8811 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:60781806-60782032 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:60782895-60783686 Neighboring gene uncharacterized LOC105371855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12542 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12543 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:60817295-60817950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60827154-60827763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:60827764-60828372 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:60839055-60839580 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60839581-60840107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8813 Neighboring gene MARCHF10 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:60902506-60903242 Neighboring gene PRELI domain containing 3B pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. Morokuma Y, et al. J Biol Chem, 2007 Aug 24. PMID 17604280
    2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. Aouizerat BE, et al. BMC Cardiovasc Disord, 2011 Jun 10. PMID 21658281, Free PMC Article
    3. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. Yoshida T, et al. Int J Mol Med, 2009 Oct. PMID 19724895
    4. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. Oguri M, et al. Am J Hypertens, 2010 Jan. PMID 19851296
    5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. Yoshida T, et al. Int J Mol Med, 2010 Apr. PMID 20198315

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ35757

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase MARCHF10
    Names
    RING-type E3 ubiquitin transferase MARCH10
    RING-type E3 ubiquitin transferase MARCHF10
    membrane associated ring finger 10
    membrane-associated RING finger protein 10
    membrane-associated RING-CH protein X
    membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase
    probable E3 ubiquitin-protein ligase MARCH10
    ring finger protein 190
    testis secretory sperm-binding protein Li 228n
    NP_001094345.1
    NP_001275708.1
    NP_001275709.1
    NP_689811.2
    XP_005257152.2
    XP_005257153.2
    XP_005257154.2
    XP_005257155.2
    XP_005257157.2
    XP_005257159.2
    XP_005257160.1
    XP_005257163.2
    XP_011522737.1
    XP_011522738.1
    XP_011522739.1
    XP_054171230.1
    XP_054171231.1
    XP_054171232.1
    XP_054171233.1
    XP_054171234.1
    XP_054171235.1
    XP_054171236.1
    XP_054171237.1
    XP_054171238.1
    XP_054171239.1
    XP_054171240.1
    XP_054171241.1
    XP_054171242.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100875.3 → NP_001094345.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform 1

      See identical proteins and their annotated locations for NP_001094345.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. Variants 1 and 2 encode the same isoform (1), which is shorter than isoform 2.
      Source sequence(s)
      AK093076, AK122947, AW473122, BC035021
      Consensus CDS
      CCDS11635.1
      UniProtKB/Swiss-Prot
      D3DU09, Q8IYS7, Q8N7Z7, Q8NA82
      UniProtKB/TrEMBL
      A0A140VKA1, B3KVK0
      Related
      ENSP00000416177.2, ENST00000456609.6
      Conserved Domains (1) summary
      smart00744
      Location:659 → 715
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    2. NM_001288779.2 → NP_001275708.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform 2

      See identical proteins and their annotated locations for NP_001275708.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (2).
      Source sequence(s)
      AW138484, AW473122, BC035021, BX648705
      Consensus CDS
      CCDS74123.1
      UniProtKB/TrEMBL
      B3KVK0, J3KTN9
      Related
      ENSP00000463080.1, ENST00000583600.5
      Conserved Domains (1) summary
      smart00744
      Location:697 → 753
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    3. NM_001288780.2 → NP_001275709.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform 3

      See identical proteins and their annotated locations for NP_001275709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and contains multiple coding region differences, compared to variant 3. It encodes isoform 3, which is shorter and has a distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AI223162, AI262871, AK122947, AW263642, BC035021, BX105355, HY010920
      Consensus CDS
      CCDS74122.1
      UniProtKB/TrEMBL
      B3KVK0, G3V1Q5
      Related
      ENSP00000443746.2, ENST00000544856.6
      Conserved Domains (1) summary
      smart00744
      Location:658 → 714
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    4. NM_152598.4 → NP_689811.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform 1

      See identical proteins and their annotated locations for NP_689811.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. Variants 1 and 2 encode the same isoform (1), which is shorter than isoform 2.
      Source sequence(s)
      AK093076, AK122947, AW473122, BC035021
      Consensus CDS
      CCDS11635.1
      UniProtKB/Swiss-Prot
      D3DU09, Q8IYS7, Q8N7Z7, Q8NA82
      UniProtKB/TrEMBL
      A0A140VKA1, B3KVK0
      Related
      ENSP00000311496.5, ENST00000311269.10
      Conserved Domains (1) summary
      smart00744
      Location:659 → 715
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      62701314..62808314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005257102.4 → XP_005257159.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X5

      UniProtKB/TrEMBL
      B3KVK0
      Conserved Domains (1) summary
      smart00744
      Location:658 → 714
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    2. XM_005257100.4 → XP_005257157.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X4

      See identical proteins and their annotated locations for XP_005257157.2

      UniProtKB/TrEMBL
      B3KVK0
      Conserved Domains (1) summary
      smart00744
      Location:659 → 715
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    3. XM_005257098.4 → XP_005257155.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X2

      UniProtKB/TrEMBL
      B3KVK0
      Conserved Domains (1) summary
      smart00744
      Location:696 → 752
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    4. XM_011524435.3 → XP_011522737.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X3

      UniProtKB/TrEMBL
      B3KVK0
      Conserved Domains (1) summary
      smart00744
      Location:696 → 752
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    5. XM_005257095.4 → XP_005257152.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

      See identical proteins and their annotated locations for XP_005257152.2

      UniProtKB/TrEMBL
      B3KVK0
      Conserved Domains (1) summary
      smart00744
      Location:697 → 753
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    6. XM_011524436.2 → XP_011522738.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X4

      See identical proteins and their annotated locations for XP_011522738.1

      UniProtKB/TrEMBL
      B3KVK0
      Conserved Domains (1) summary
      smart00744
      Location:659 → 715
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    7. XM_005257096.3 → XP_005257153.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

      See identical proteins and their annotated locations for XP_005257153.2

      UniProtKB/TrEMBL
      B3KVK0
      Conserved Domains (1) summary
      smart00744
      Location:697 → 753
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    8. XM_011524437.3 → XP_011522739.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X6

      UniProtKB/TrEMBL
      B3KVK0
      Conserved Domains (1) summary
      smart00744
      Location:658 → 714
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    9. XM_005257097.3 → XP_005257154.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

      See identical proteins and their annotated locations for XP_005257154.2

      UniProtKB/TrEMBL
      B3KVK0
      Conserved Domains (1) summary
      smart00744
      Location:697 → 753
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    10. XM_005257106.4 → XP_005257163.2  probable E3 ubiquitin-protein ligase MARCHF10 isoform X8

      UniProtKB/TrEMBL
      J3QRH7
      Related
      ENSP00000464220.1, ENST00000580520.5
      Conserved Domains (1) summary
      smart00744
      Location:586 → 642
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    11. XM_005257103.3 → XP_005257160.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X7

      See identical proteins and their annotated locations for XP_005257160.1

      UniProtKB/TrEMBL
      B3KVK0, G3V1Q5
      Conserved Domains (1) summary
      smart00744
      Location:658 → 714
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RNA

    1. XR_934406.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      63571227..63678377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315262.1 → XP_054171237.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X5

      UniProtKB/TrEMBL
      B3KVK0

    2. XM_054315260.1 → XP_054171235.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X4

      UniProtKB/TrEMBL
      B3KVK0

    3. XM_054315258.1 → XP_054171233.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X2

      UniProtKB/TrEMBL
      B3KVK0

    4. XM_054315259.1 → XP_054171234.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X3

      UniProtKB/TrEMBL
      B3KVK0

    5. XM_054315255.1 → XP_054171230.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

      UniProtKB/TrEMBL
      B3KVK0

    6. XM_054315261.1 → XP_054171236.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X4

      UniProtKB/TrEMBL
      B3KVK0

    7. XM_054315256.1 → XP_054171231.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

      UniProtKB/TrEMBL
      B3KVK0

    8. XM_054315263.1 → XP_054171238.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X6

      UniProtKB/TrEMBL
      B3KVK0

    9. XM_054315257.1 → XP_054171232.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X1

      UniProtKB/TrEMBL
      B3KVK0

    10. XM_054315265.1 → XP_054171240.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X8

      UniProtKB/TrEMBL
      J3QRH7

    11. XM_054315264.1 → XP_054171239.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X7

      UniProtKB/TrEMBL
      B3KVK0

    12. XM_054315266.1 → XP_054171241.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X9

    13. XM_054315267.1 → XP_054171242.1  probable E3 ubiquitin-protein ligase MARCHF10 isoform X9

    RNA

    1. XR_008484791.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NA82.3 GenPept UniProtKB/Swiss-Prot:Q8NA82

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