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    STRBP spermatid perinuclear RNA binding protein [ Homo sapiens (human) ]

    Gene ID: 55342, updated on 27-Nov-2024

    Summary

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    Official Symbol
    STRBPprovided by HGNC
    Official Full Name
    spermatid perinuclear RNA binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16462
    See related
    Ensembl:ENSG00000165209 MIM:611138; AllianceGenome:HGNC:16462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p74; SPNR; ILF3L; HEL162
    Summary
    Enables RNA binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to act upstream of or within cell motility; mechanosensory behavior; and spermatid development. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 6.5), lymph node (RPKM 4.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STRBP in Genome Data Viewer
    Location:
    9q33.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (123109494..123268586, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (135300815..135465770, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125883548..126030865, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RAB GTPase activating protein 1 Neighboring gene COP9 signalosome subunit 2 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:125834601-125835274 Neighboring gene G protein-coupled receptor 21 Neighboring gene Sharpr-MPRA regulatory region 8358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28932 Neighboring gene MIR600 host gene Neighboring gene microRNA 600 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:125937073-125937784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20247 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:126030691-126031191 Neighboring gene uncharacterized LOC105376265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28936 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126088537-126089038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:126089039-126089538 Neighboring gene uncharacterized LOC124902266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28937 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28938

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression of STRBP mRNA in patients with cryptorchidism and Down's syndrome. Salemi M, et al. J Endocrinol Invest, 2012 Jan. PMID 22391137
    2. CircSTRBP contributes to H(2)O(2)-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1. Li D, et al. Exp Eye Res, 2024 Apr. PMID 38340945
    3. Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression. Chen SY, et al. Cancer Lett, 2024 Apr 1. PMID 38280476
    4. Spnr, a murine RNA-binding protein that is localized to cytoplasmic microtubules. Schumacher JM, et al. J Cell Biol, 1995 May. PMID 7744952, Free PMC Article
    5. Mice deficient for spermatid perinuclear RNA-binding protein show neurologic, spermatogenic, and sperm morphological abnormalities. Pires-daSilva A, et al. Dev Biol, 2001 May 15. PMID 11336498

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircSTRBP contributes to H2O2-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1.
      Title: CircSTRBP contributes to H(2)O(2)-induced lens epithelium cell dysfunction through increasing NOX4 mRNA stability by recruiting IGF2BP1.
    2. Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.
      Title: Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.
    3. Low STRBP mRNA is associated with cryptorchidism and Down's syndrome.
      Title: Expression of STRBP mRNA in patients with cryptorchidism and Down's syndrome.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3405, FLJ11307, FLJ14223, FLJ14984, FLJ21960, MGC21529, DKFZp434N214

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mechanosensory behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatid development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in manchette IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    spermatid perinuclear RNA-binding protein
    Names
    epididymis luminal protein 162
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171137.2 → NP_001164608.1  spermatid perinuclear RNA-binding protein isoform 2

      See identical proteins and their annotated locations for NP_001164608.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR but has a downstream additional exon, which results in a downstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) is shorter than isoform 1 at the N-terminus.
      Source sequence(s)
      AL136866, AL365338, AL365504, BC002693
      Consensus CDS
      CCDS55337.1
      UniProtKB/Swiss-Prot
      Q96SI9
      Related
      ENSP00000354271.3, ENST00000360998.3
      Conserved Domains (4) summary
      smart00572
      Location:67 → 320
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:594 → 653
      SGP; Sulphur globule protein
      cd19909
      Location:370 → 453
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:498 → 561
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    2. NM_001376106.1 → NP_001363035.1  spermatid perinuclear RNA-binding protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL365338, AL365504
      Consensus CDS
      CCDS6851.1
      UniProtKB/Swiss-Prot
      Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
      UniProtKB/TrEMBL
      V9HWK4
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 667
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    3. NM_001376107.1 → NP_001363036.1  spermatid perinuclear RNA-binding protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL365338, AL365504
      Consensus CDS
      CCDS6851.1
      UniProtKB/Swiss-Prot
      Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
      UniProtKB/TrEMBL
      V9HWK4
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 667
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    4. NM_001376109.1 → NP_001363038.1  spermatid perinuclear RNA-binding protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL365338, AL365504
      Conserved Domains (3) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    5. NM_018387.5 → NP_060857.2  spermatid perinuclear RNA-binding protein isoform 1

      See identical proteins and their annotated locations for NP_060857.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL365338, AL365504, BC002693, BC017732
      Consensus CDS
      CCDS6851.1
      UniProtKB/Swiss-Prot
      Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
      UniProtKB/TrEMBL
      V9HWK4
      Related
      ENSP00000321347.7, ENST00000348403.10
      Conserved Domains (4) summary
      smart00572
      Location:81 → 334
      DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
      pfam17228
      Location:608 → 667
      SGP; Sulphur globule protein
      cd19909
      Location:384 → 467
      DSRM_STRBP_rpt1; first double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins
      cd19911
      Location:512 → 575
      DSRM_STRBP_rpt2; second double-stranded RNA binding motif of spermatid perinuclear RNA-binding protein (STRBP) and similar proteins

    RNA

    1. NR_033234.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has several alternate splice sites, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate.
      Source sequence(s)
      AL365338, AL365504, AL834150, BC108731

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      123109494..123268586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423563.1 → XP_047279519.1  spermatid perinuclear RNA-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z5K8

    2. XM_047423562.1 → XP_047279518.1  spermatid perinuclear RNA-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
      UniProtKB/TrEMBL
      V9HWK4
      Related
      ENSP00000415968.2, ENST00000447404.6

    RNA

    1. XR_007061327.1 RNA Sequence

    2. XR_007061326.1 RNA Sequence

    3. XR_001746347.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      135300815..135465770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363231.1 → XP_054219206.1  spermatid perinuclear RNA-binding protein isoform X3

    2. XM_054363230.1 → XP_054219205.1  spermatid perinuclear RNA-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z5K8

    3. XM_054363225.1 → XP_054219200.1  spermatid perinuclear RNA-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
      UniProtKB/TrEMBL
      V9HWK4

    4. XM_054363229.1 → XP_054219204.1  spermatid perinuclear RNA-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A0S2Z5K8

    5. XM_054363226.1 → XP_054219201.1  spermatid perinuclear RNA-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
      UniProtKB/TrEMBL
      V9HWK4

    6. XM_054363228.1 → XP_054219203.1  spermatid perinuclear RNA-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
      UniProtKB/TrEMBL
      V9HWK4

    7. XM_054363227.1 → XP_054219202.1  spermatid perinuclear RNA-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q32NB9, Q96SI9, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
      UniProtKB/TrEMBL
      V9HWK4

    RNA

    1. XR_008488043.1 RNA Sequence

    2. XR_008488042.1 RNA Sequence

    3. XR_008488040.1 RNA Sequence

    4. XR_008488044.1 RNA Sequence

    5. XR_008488041.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96SI9.1 GenPept UniProtKB/Swiss-Prot:Q96SI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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