PTPN3 protein tyrosine phosphatase non-receptor type 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTPN3provided by HGNC
Official Full Name: protein tyrosine phosphatase non-receptor type 3provided by HGNC
Primary source: HGNC:HGNC:9655
See related: Ensembl:ENSG00000070159 MIM:176877; AllianceGenome:HGNC:9655
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PTPH1; PTP-H1
Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
Expression: Broad expression in skin (RPKM 9.4), kidney (RPKM 7.8) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q31.3

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (109375694..109538420, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (121545088..121707765, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (112137974..112260587, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of PTPN3 Expressed in Activated Lymphocytes Enhances the Antitumor Effects of Anti-PD-1 Therapy in Head and Neck Cancer, Especially in Hypoxic Environments.
Title: Inhibition of PTPN3 Expressed in Activated Lymphocytes Enhances the Antitumor Effects of Anti-PD-1 Therapy in Head and Neck Cancer, Especially in Hypoxic Environments.
Identification and verification of PTPN3 as a novel biomarker in predicting cancer prognosis, immunity, and immunotherapeutic efficacy.
Title: Identification and verification of PTPN3 as a novel biomarker in predicting cancer prognosis, immunity, and immunotherapeutic efficacy.
PTPN3 Could Betae a Therapeutic Target of Pancreatic Cancer.
Title: PTPN3 Could Βe a Therapeutic Target of Pancreatic Cancer.
Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Title: Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling.
Title: PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling.
NFkappaB and TGFbeta contribute to the expression of PTPN3 in activated human lymphocytes.
Title: NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytes.
Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein.
Title: Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein.
PTPN3 suppressed the proliferation of perihilar cholangiocarcinoma by inhibiting AKT phosphorylation and arresting cell cycle.
Title: PTPN3 suppresses the proliferation and correlates with favorable prognosis of perihilar cholangiocarcinoma by inhibiting AKT phosphorylation.
Low PTPN3 expression is associated with gastric cancer angiogenesis.
Title: MicroRNA-574-5p in gastric cancer cells promotes angiogenesis by targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3).
findings reveal a novel mechanism by which reversible tyrosine phosphorylation of DAAM1 by Src and PTPN3 regulates actin dynamics and lung cancer invasivenes
Title: PTPN3 suppresses lung cancer cell invasiveness by counteracting Src-mediated DAAM1 activation and actin polymerization.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78381 (e-PCR)
- UniSTS:38153

RH91146 (e-PCR)
- UniSTS:88337

D9S1760 (e-PCR)
- UniSTS:12586

D9S58 (e-PCR)
- UniSTS:33358

RH48492 (e-PCR)
- UniSTS:21072

SHGC-149695 (e-PCR)
- UniSTS:184926

PTPN3_2445 (e-PCR)
- UniSTS:280941

UniSTS:25220 (e-PCR)
- UniSTS:25220

A009V09 (e-PCR)
- UniSTS:77964

D9S1693 (e-PCR)
- UniSTS:65182

STS-W15441 (e-PCR)
- UniSTS:82348

G32870 (e-PCR)
- UniSTS:117449

WI-10390 (e-PCR)
- UniSTS:64756

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	TAS Traceable Author Statement more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables sodium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	TAS Traceable Author Statement more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	TAS Traceable Author Statement more info
involved_in negative regulation of membrane protein ectodomain proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane depolarization during action potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of sodium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 3

Names: cytoskeletal-associated protein tyrosine phosphatase; protein-tyrosine phosphatase H1

NP_001138840.1

EC 3.1.3.48

NP_001138841.1

EC 3.1.3.48

NP_001138842.1

EC 3.1.3.48

NP_001138843.1

EC 3.1.3.48

NP_001138844.1

EC 3.1.3.48

NP_002820.3

EC 3.1.3.48

XP_006717262.1

EC 3.1.3.48

XP_006717265.1

EC 3.1.3.48

XP_006717266.1

EC 3.1.3.48

XP_011517190.1

EC 3.1.3.48

XP_016870444.1

EC 3.1.3.48

XP_047279590.1

EC 3.1.3.48

XP_047279591.1

EC 3.1.3.48

XP_047279592.1

EC 3.1.3.48

XP_047279593.1

EC 3.1.3.48

XP_047279594.1

EC 3.1.3.48

XP_047279595.1

EC 3.1.3.48

XP_054219352.1

EC 3.1.3.48

XP_054219353.1

EC 3.1.3.48

XP_054219354.1

EC 3.1.3.48

XP_054219355.1

EC 3.1.3.48

XP_054219356.1

EC 3.1.3.48

XP_054219357.1

EC 3.1.3.48

XP_054219358.1

EC 3.1.3.48

XP_054219359.1

EC 3.1.3.48

XP_054219360.1

EC 3.1.3.48

XP_054219361.1

EC 3.1.3.48

XP_054219362.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047071.1 RefSeqGene

Range

45047..167654

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001145368.2 → NP_001138840.1 tyrosine-protein phosphatase non-receptor type 3 isoform 2

See identical proteins and their annotated locations for NP_001138840.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) is missing an in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1.

Source sequence(s)

AK096975, AK316066, AL359963, BC033716, BC126117, DB173093

UniProtKB/TrEMBL

B7Z948, B7Z9V1

Conserved Domains (7) summary

smart00194
Location:604 → 855

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00295
Location:31 → 222

B41; Band 4.1 homologues

cd00047
Location:627 → 854

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00992
Location:463 → 550

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 309

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

pfam00373
Location:115 → 222

FERM_M; FERM central domain

pfam09379
Location:33 → 96

FERM_N; FERM N-terminal domain
NM_001145369.2 → NP_001138841.1 tyrosine-protein phosphatase non-receptor type 3 isoform 3

See identical proteins and their annotated locations for NP_001138841.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, and initiates translation from an in-frame downstream AUG, resulting in an isoform (3) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK096975, AL162733, AL359963, BX648253, BX648735, DB173093, DB306298

Consensus CDS

CCDS48001.1

UniProtKB/TrEMBL

B7Z3H5

Related

ENSP00000416654.1, ENST00000412145.5

Conserved Domains (4) summary

smart00295
Location:2 → 91

B41; Band 4.1 homologues

cd00992
Location:377 → 464

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:85 → 178

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:500 → 773

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
NM_001145370.2 → NP_001138842.1 tyrosine-protein phosphatase non-receptor type 3 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, and is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (4) with a shorter N-terminus and lacking an internal protein segment compared to isoform 1.

Source sequence(s)

AK096975, AL162733, AL359963, BX648253, BX648735, DB173093, DB306298

Consensus CDS

CCDS48000.1

UniProtKB/TrEMBL

B7Z3H5

Related

ENSP00000395384.1, ENST00000446349.5

Conserved Domains (4) summary

smart00295
Location:2 → 91

B41; Band 4.1 homologues

cd00992
Location:332 → 419

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:85 → 178

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:455 → 728

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
NM_001145371.2 → NP_001138843.1 tyrosine-protein phosphatase non-receptor type 3 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, and initiates translation from an in-frame downstream AUG, resulting in an isoform (5) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK096975, AK296388, AL359963, BC033716, BC126117, DB173093, DC342461

UniProtKB/TrEMBL

B7Z3V3

Conserved Domains (3) summary

cd00992
Location:221 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14600
Location:344 → 617

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

cl17171
Location:1 → 22

PH-like; Pleckstrin homology-like domain
NM_001145372.2 → NP_001138844.1 tyrosine-protein phosphatase non-receptor type 3 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, and is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (6) with a shorter N-terminus and lacking an internal protein segment compared to isoform 1.

Source sequence(s)

AK096975, AK316118, AL359963, BC033716, DB173093, DC342461

UniProtKB/TrEMBL

B7Z3R0, B7ZA03

Conserved Domains (3) summary

cd00992
Location:176 → 263

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd14600
Location:299 → 572

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

cl17171
Location:1 → 22

PH-like; Pleckstrin homology-like domain
NM_002829.4 → NP_002820.3 tyrosine-protein phosphatase non-receptor type 3 isoform 1

See identical proteins and their annotated locations for NP_002820.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK096975, AK316066, AL359963, BC033716, BC126117, DB173093

Consensus CDS

CCDS6776.1

UniProtKB/Swiss-Prot

A0AUW9, E7EN99, E9PGU7, P26045

UniProtKB/TrEMBL

B7Z948

Related

ENSP00000363667.1, ENST00000374541.4

Conserved Domains (4) summary

smart00295
Location:31 → 222

B41; Band 4.1 homologues

cd00992
Location:508 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 309

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:631 → 904

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3

RNA

NR_026918.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (7) contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK096975, AK303608, AL359963, BC033716, BU624870, DB173093

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

109375694..109538420 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011518888.3 → XP_011517190.1 tyrosine-protein phosphatase non-receptor type 3 isoform X2

UniProtKB/TrEMBL

B7Z948

Conserved Domains (7) summary

smart00194
Location:670 → 921

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00295
Location:52 → 243

B41; Band 4.1 homologues

cd00047
Location:693 → 920

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00992
Location:529 → 616

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:237 → 330

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

pfam00373
Location:136 → 243

FERM_M; FERM central domain

pfam09379
Location:54 → 117

FERM_N; FERM N-terminal domain
XM_006717199.4 → XP_006717262.1 tyrosine-protein phosphatase non-receptor type 3 isoform X1

See identical proteins and their annotated locations for XP_006717262.1

UniProtKB/Swiss-Prot

A0AUW9, E7EN99, E9PGU7, P26045

UniProtKB/TrEMBL

B7Z948

Conserved Domains (4) summary

smart00295
Location:31 → 222

B41; Band 4.1 homologues

cd00992
Location:508 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 309

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:631 → 904

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
XM_047423636.1 → XP_047279592.1 tyrosine-protein phosphatase non-receptor type 3 isoform X4

UniProtKB/TrEMBL

B7Z948
XM_017014955.2 → XP_016870444.1 tyrosine-protein phosphatase non-receptor type 3 isoform X1

UniProtKB/Swiss-Prot

A0AUW9, E7EN99, E9PGU7, P26045

UniProtKB/TrEMBL

B7Z948

Conserved Domains (4) summary

smart00295
Location:31 → 222

B41; Band 4.1 homologues

cd00992
Location:508 → 595

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:216 → 309

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

cd14600
Location:631 → 904

PTPc-N3; catalytic domain of tyrosine-protein phosphatase non-receptor type 3
XM_047423635.1 → XP_047279591.1 tyrosine-protein phosphatase non-receptor type 3 isoform X3

UniProtKB/TrEMBL

B7Z948
XM_047423634.1 → XP_047279590.1 tyrosine-protein phosphatase non-receptor type 3 isoform X1

UniProtKB/Swiss-Prot

A0AUW9, E7EN99, E9PGU7, P26045

UniProtKB/TrEMBL

B7Z948
XM_047423637.1 → XP_047279593.1 tyrosine-protein phosphatase non-receptor type 3 isoform X5

UniProtKB/TrEMBL

B7Z948
XM_047423638.1 → XP_047279594.1 tyrosine-protein phosphatase non-receptor type 3 isoform X6

UniProtKB/TrEMBL

B7Z3H5
XM_006717202.4 → XP_006717265.1 tyrosine-protein phosphatase non-receptor type 3 isoform X7

See identical proteins and their annotated locations for XP_006717265.1

UniProtKB/TrEMBL

B7Z3H5

Conserved Domains (6) summary

smart00194
Location:534 → 785

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00295
Location:6 → 107

B41; Band 4.1 homologues

cd00047
Location:557 → 784

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00992
Location:393 → 480

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:101 → 194

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

pfam00373
Location:8 → 107

FERM_M; FERM central domain
XM_006717203.5 → XP_006717266.1 tyrosine-protein phosphatase non-receptor type 3 isoform X7

See identical proteins and their annotated locations for XP_006717266.1

UniProtKB/TrEMBL

B7Z3H5

Conserved Domains (6) summary

smart00194
Location:534 → 785

PTPc; Protein tyrosine phosphatase, catalytic domain

smart00295
Location:6 → 107

B41; Band 4.1 homologues

cd00047
Location:557 → 784

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00992
Location:393 → 480

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13189
Location:101 → 194

FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

pfam00373
Location:8 → 107

FERM_M; FERM central domain
XM_047423639.1 → XP_047279595.1 tyrosine-protein phosphatase non-receptor type 3 isoform X8

UniProtKB/TrEMBL

B7Z3R0, B7ZA03

Alternate T2T-CHM13v2.0

Genomic

NC_060933.1 Alternate T2T-CHM13v2.0

Range

121545088..121707765 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054363378.1 → XP_054219353.1 tyrosine-protein phosphatase non-receptor type 3 isoform X2

UniProtKB/TrEMBL

B7Z948
XM_054363382.1 → XP_054219357.1 tyrosine-protein phosphatase non-receptor type 3 isoform X1

UniProtKB/Swiss-Prot

A0AUW9, E7EN99, E9PGU7, P26045

UniProtKB/TrEMBL

B7Z948
XM_054363381.1 → XP_054219356.1 tyrosine-protein phosphatase non-receptor type 3 isoform X1

UniProtKB/Swiss-Prot

A0AUW9, E7EN99, E9PGU7, P26045

UniProtKB/TrEMBL

B7Z948
XM_054363379.1 → XP_054219354.1 tyrosine-protein phosphatase non-receptor type 3 isoform X3

UniProtKB/TrEMBL

B7Z948
XM_054363377.1 → XP_054219352.1 tyrosine-protein phosphatase non-receptor type 3 isoform X1

UniProtKB/Swiss-Prot

A0AUW9, E7EN99, E9PGU7, P26045

UniProtKB/TrEMBL

B7Z948
XM_054363383.1 → XP_054219358.1 tyrosine-protein phosphatase non-receptor type 3 isoform X5

UniProtKB/TrEMBL

B7Z948
XM_054363380.1 → XP_054219355.1 tyrosine-protein phosphatase non-receptor type 3 isoform X4

UniProtKB/TrEMBL

B7Z948
XM_054363384.1 → XP_054219359.1 tyrosine-protein phosphatase non-receptor type 3 isoform X6

UniProtKB/TrEMBL

B7Z3H5
XM_054363385.1 → XP_054219360.1 tyrosine-protein phosphatase non-receptor type 3 isoform X7

UniProtKB/TrEMBL

B7Z3H5
XM_054363386.1 → XP_054219361.1 tyrosine-protein phosphatase non-receptor type 3 isoform X7

UniProtKB/TrEMBL

B7Z3H5
XM_054363387.1 → XP_054219362.1 tyrosine-protein phosphatase non-receptor type 3 isoform X8

UniProtKB/TrEMBL

B7Z3R0, B7ZA03